diff --git a/packages/purgecss-from-html/src/index.ts b/packages/purgecss-from-html/src/index.ts
index 1e20d016..f27d9cab 100644
--- a/packages/purgecss-from-html/src/index.ts
+++ b/packages/purgecss-from-html/src/index.ts
@@ -35,7 +35,7 @@ const mergedExtractorResults = (
 };
 
 const getSelectorsInElement = (
-  element: htmlparser2.Htmlparser2TreeAdapterMap['element']
+  element: htmlparser2.Htmlparser2TreeAdapterMap["element"]
 ): ExtractorResultDetailed => {
   const result: ExtractorResultDetailed = {
     attributes: {
@@ -63,7 +63,9 @@ const getSelectorsInElement = (
 };
 
 const getSelectorsInNodes = (
-  node: htmlparser2.Htmlparser2TreeAdapterMap['document'] | htmlparser2.Htmlparser2TreeAdapterMap['element']
+  node:
+    | htmlparser2.Htmlparser2TreeAdapterMap["document"]
+    | htmlparser2.Htmlparser2TreeAdapterMap["element"]
 ): ExtractorResultDetailed => {
   let result: ExtractorResultDetailed = {
     attributes: {
@@ -103,7 +105,7 @@ const getSelectorsInNodes = (
  */
 const purgecssFromHtml = (content: string): ExtractorResultDetailed => {
   const tree = parse5.parse(content, {
-    treeAdapter: htmlparser2.adapter
+    treeAdapter: htmlparser2.adapter,
   });
 
   return getSelectorsInNodes(tree);
diff --git a/packages/purgecss/__tests__/pseudo-class.test.ts b/packages/purgecss/__tests__/pseudo-class.test.ts
index 63819a4c..ef5cd9dc 100644
--- a/packages/purgecss/__tests__/pseudo-class.test.ts
+++ b/packages/purgecss/__tests__/pseudo-class.test.ts
@@ -100,3 +100,37 @@ describe("pseudo classes", () => {
     expect(purgedCSS.includes("row:after")).toBe(false);
   });
 });
+
+describe(":where pseudo class", () => {
+  let purgedCSS: string;
+  beforeAll(async () => {
+    const resultsPurge = await new PurgeCSS().purge({
+      content: [`${ROOT_TEST_EXAMPLES}pseudo-class/where.html`],
+      css: [`${ROOT_TEST_EXAMPLES}pseudo-class/where.css`],
+    });
+    purgedCSS = resultsPurge[0].css;
+  });
+
+  it("removes unused selectors", () => {
+    expect(purgedCSS.includes(".unused")).toBe(false);
+    expect(purgedCSS.includes(".root :where(.a) .c {")).toBe(true);
+    expect(purgedCSS.includes(".root:where(.a) .c {")).toBe(true);
+  });
+});
+
+describe(":is pseudo class", () => {
+  let purgedCSS: string;
+  beforeAll(async () => {
+    const resultsPurge = await new PurgeCSS().purge({
+      content: [`${ROOT_TEST_EXAMPLES}pseudo-class/is.html`],
+      css: [`${ROOT_TEST_EXAMPLES}pseudo-class/is.css`],
+    });
+    purgedCSS = resultsPurge[0].css;
+  });
+
+  it("removes unused selectors", () => {
+    expect(purgedCSS.includes(".unused")).toBe(false);
+    expect(purgedCSS.includes(".root :is(.a) .c {")).toBe(true);
+    expect(purgedCSS.includes(".root:is(.a) .c {")).toBe(true);
+  });
+});
diff --git a/packages/purgecss/__tests__/test_examples/pseudo-class/is.css b/packages/purgecss/__tests__/test_examples/pseudo-class/is.css
new file mode 100644
index 00000000..5f22ab8e
--- /dev/null
+++ b/packages/purgecss/__tests__/test_examples/pseudo-class/is.css
@@ -0,0 +1,24 @@
+.root :is(.a, .b) .unused {
+  color: red;
+}
+
+.root :is(.a, .unused) .c {
+  color: blue;
+}
+
+.root :is(.a, .b) .c :is(.unused, .unused2) {
+  color: green;
+}
+
+.root:is(.unused) .c {
+  color: rebeccapurple;
+}
+
+.root:is(.a) .c {
+  color: cyan;
+}
+
+.root :is(.unused) .c,
+.root :is(.a, .b) .c :is(.unused, .unused2) {
+  display: flex;
+}
\ No newline at end of file
diff --git a/packages/purgecss/__tests__/test_examples/pseudo-class/is.html b/packages/purgecss/__tests__/test_examples/pseudo-class/is.html
new file mode 100644
index 00000000..fd573c34
--- /dev/null
+++ b/packages/purgecss/__tests__/test_examples/pseudo-class/is.html
@@ -0,0 +1,8 @@
+<div class="root">
+  <div class="a">
+    <div class="c"></div>
+  </div>
+  <div class="b">
+    <div class="c"></div>
+  </div>
+</div>
\ No newline at end of file
diff --git a/packages/purgecss/__tests__/test_examples/pseudo-class/where.css b/packages/purgecss/__tests__/test_examples/pseudo-class/where.css
new file mode 100644
index 00000000..d920bcbc
--- /dev/null
+++ b/packages/purgecss/__tests__/test_examples/pseudo-class/where.css
@@ -0,0 +1,24 @@
+.root :where(.a, .b) .unused {
+  color: red;
+}
+
+.root :where(.a, .unused) .c {
+  color: blue;
+}
+
+.root :where(.a, .b) .c :where(.unused, .unused2) {
+  color: green;
+}
+
+.root:where(.unused) .c {
+  color: rebeccapurple;
+}
+
+.root:where(.a) .c {
+  color: cyan;
+}
+
+.root :where(.unused) .c,
+.root :where(.a, .b) .c :where(.unused, .unused2) {
+  display: flex;
+}
\ No newline at end of file
diff --git a/packages/purgecss/__tests__/test_examples/pseudo-class/where.html b/packages/purgecss/__tests__/test_examples/pseudo-class/where.html
new file mode 100644
index 00000000..fd573c34
--- /dev/null
+++ b/packages/purgecss/__tests__/test_examples/pseudo-class/where.html
@@ -0,0 +1,8 @@
+<div class="root">
+  <div class="a">
+    <div class="c"></div>
+  </div>
+  <div class="b">
+    <div class="c"></div>
+  </div>
+</div>
\ No newline at end of file
diff --git a/packages/purgecss/src/index.ts b/packages/purgecss/src/index.ts
index 05e6516b..28970474 100644
--- a/packages/purgecss/src/index.ts
+++ b/packages/purgecss/src/index.ts
@@ -289,6 +289,20 @@ function isInPseudoClass(selector: selectorParser.Node): boolean {
   );
 }
 
+/**
+ * Returns true if the selector is inside the pseudo classes :where() or :is()
+ * @param selector - selector
+ */
+function isInPseudoClassWhereOrIs(selector: selectorParser.Node): boolean {
+  return (
+    (selector.parent &&
+      selector.parent.type === "pseudo" &&
+      (selector.parent.value === ":where" ||
+        selector.parent.value === ":is")) ||
+    false
+  );
+}
+
 function isPostCSSAtRule(node?: postcss.Node): node is postcss.AtRule {
   return node?.type === "atrule";
 }
@@ -511,6 +525,13 @@ class PurgeCSS {
 
     let keepSelector = true;
     const selectorsRemovedFromRule: string[] = [];
+
+    // selector transformer, walk over the list of the parsed selectors twice.
+    // First pass will remove the unused selectors. It goes through
+    // pseudo-classes like :where() and :is() and remove the unused
+    // selectors inside of them, but will not remove the pseudo-classes
+    // themselves. Second pass will remove selectors containing empty
+    // :where and :is.
     node.selector = selectorParser((selectorsParsed) => {
       selectorsParsed.walk((selector) => {
         if (selector.type !== "selector") {
@@ -529,6 +550,19 @@ class PurgeCSS {
           selector.remove();
         }
       });
+
+      selectorsParsed.walk((selector) => {
+        if (selector.type !== "selector") {
+          return;
+        }
+
+        if (
+          selector.toString() &&
+          /(:where$)|(:is$)|(:where[^(])|(:is[^(])/.test(selector.toString())
+        ) {
+          selector.remove();
+        }
+      });
     }).processSync(node.selector);
 
     // declarations
@@ -815,8 +849,10 @@ class PurgeCSS {
     selector: selectorParser.Selector,
     selectorsFromExtractor: ExtractorResultSets
   ): boolean {
-    // ignore the selector if it is inside a pseudo class
-    if (isInPseudoClass(selector)) return true;
+    // selectors in pseudo classes are ignored except :where() and :is(). For those pseudo-classes, we are treating the selectors inside the same way as they would be outside.
+    if (isInPseudoClass(selector) && !isInPseudoClassWhereOrIs(selector)) {
+      return true;
+    }
 
     // if there is any greedy safelist pattern, run all the selector parts through them
     // if there is any match, return true