model_PKA_cycle.xml

<?xml version="1.0" encoding="UTF-8"?>
<!-- Created by COPASI version 4.22 (Build 170) on 2018-10-08 08:14 with libSBML version 5.15.3. -->
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
  <model metaid="COPASI0" id="PKA__cycle" name="PKA  cycle">
    <annotation>
      <COPASI xmlns="http://www.copasi.org/static/sbml">
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          <rdf:Description rdf:about="#COPASI0">
            <dcterms:created>
              <rdf:Description>
                <dcterms:W3CDTF>2017-09-21T12:32:20Z</dcterms:W3CDTF>
              </rdf:Description>
            </dcterms:created>
            <dcterms:creator>
              <rdf:Bag>
                <rdf:li>
                  <rdf:Description>
                    <vCard:N>
                      <rdf:Description>
                        <vCard:Family>Hasenauer</vCard:Family>
                        <vCard:Given>Jan</vCard:Given>
                      </rdf:Description>
                    </vCard:N>
                    <vCard:ORG>
                      <rdf:Description>
                        <vCard:Orgname>Helmholtz Zentrum </vCard:Orgname>
                      </rdf:Description>
                    </vCard:ORG>
                  </rdf:Description>
                </rdf:li>
              </rdf:Bag>
            </dcterms:creator>
            <dcterms:modified>
              <rdf:Description>
                <dcterms:W3CDTF>2017-09-21T12:32:20Z</dcterms:W3CDTF>
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        <rdf:Description rdf:about="#COPASI0">
          <dc:creator>
            <rdf:Bag>
              <rdf:li rdf:parseType="Resource">
                <vCard:N rdf:parseType="Resource">
                  <vCard:Family>Hasenauer</vCard:Family>
                  <vCard:Given>Jan</vCard:Given>
                </vCard:N>
                <vCard:ORG rdf:parseType="Resource">
                  <vCard:Orgname>Helmholtz Zentrum </vCard:Orgname>
                </vCard:ORG>
              </rdf:li>
            </rdf:Bag>
          </dc:creator>
          <dcterms:created rdf:parseType="Resource">
            <dcterms:W3CDTF>2017-09-21T12:32:20Z</dcterms:W3CDTF>
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          <dcterms:modified rdf:parseType="Resource">
            <dcterms:W3CDTF>2017-09-21T12:32:20Z</dcterms:W3CDTF>
          </dcterms:modified>
        </rdf:Description>
      </rdf:RDF>
    </annotation>
    <listOfFunctionDefinitions>
      <functionDefinition id="drug_flux__irreversible__3" name="drug flux (irreversible)_3">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Rp8_pCPT_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> Rp8_pCPT_cAMPS_pAB </ci>
            </bvar>
            <bvar>
              <ci> ki </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <apply>
              <times/>
              <ci> ki </ci>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> xi </ci>
                  <ci> Rp8_pCPT_cAMPS_pAB </ci>
                </apply>
                <ci> Rp8_pCPT_cAMPS </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="IBMX_flux_1" name="IBMX flux_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> IBMX </ci>
            </bvar>
            <bvar>
              <ci> IBMXex </ci>
            </bvar>
            <bvar>
              <ci> ki </ci>
            </bvar>
            <apply>
              <times/>
              <ci> ki </ci>
              <apply>
                <minus/>
                <ci> IBMXex </ci>
                <ci> IBMX </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="Mass_action__two_parameters__irreversible__1" name="Mass action, two parameters (irreversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> k2 </ci>
            </bvar>
            <bvar>
              <ci> kf_RII_C_2__RII_2 </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf_RII_C_2__RII_2 </ci>
              <ci> k2 </ci>
              <ci> RIIp_C_2 </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_3__reversible__1" name="function 3 (reversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Csub </ci>
            </bvar>
            <bvar>
              <ci> KD </ci>
            </bvar>
            <bvar>
              <ci> PDE </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <bvar>
              <ci> pPDE </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf </ci>
                <ci> Csub </ci>
                <ci> PDE </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf </ci>
                <ci> KD </ci>
                <ci> pPDE </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_7__irreversible__1" name="function 7 (irreversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Csub </ci>
            </bvar>
            <bvar>
              <ci> RIIp_2 </ci>
            </bvar>
            <bvar>
              <ci> kf_RII_2__RII_C_2 </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf_RII_2__RII_C_2 </ci>
              <ci> xi </ci>
              <ci> RIIp_2 </ci>
              <ci> Csub </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_3__reversible__2" name="function 3 (reversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> RIIp_cAMP_C_2 </ci>
            </bvar>
            <bvar>
              <ci> cAMP </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> cAMP </ci>
                <ci> RIIp_C_2 </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_cAMP_C_2 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="cAMP_degradation_1" name="cAMP degradation_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> IBMX </ci>
            </bvar>
            <bvar>
              <ci> KD_IBMX </ci>
            </bvar>
            <bvar>
              <ci> PDE </ci>
            </bvar>
            <bvar>
              <ci> cAMP </ci>
            </bvar>
            <bvar>
              <ci> kdeg_cAMP </ci>
            </bvar>
            <bvar>
              <ci> pPDE </ci>
            </bvar>
            <bvar>
              <ci> xi_pPDE </ci>
            </bvar>
            <apply>
              <times/>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> kdeg_cAMP </ci>
                  <ci> KD_IBMX </ci>
                </apply>
                <apply>
                  <plus/>
                  <ci> KD_IBMX </ci>
                  <ci> IBMX </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> PDE </ci>
                <apply>
                  <times/>
                  <ci> xi_pPDE </ci>
                  <ci> pPDE </ci>
                </apply>
              </apply>
              <ci> cAMP </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="cAMP_degradation_2" name="cAMP degradation_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> IBMX </ci>
            </bvar>
            <bvar>
              <ci> KD_IBMX </ci>
            </bvar>
            <bvar>
              <ci> PDE </ci>
            </bvar>
            <bvar>
              <ci> RIIp_cAMP_C_2 </ci>
            </bvar>
            <bvar>
              <ci> kdeg_cAMP </ci>
            </bvar>
            <bvar>
              <ci> pPDE </ci>
            </bvar>
            <bvar>
              <ci> xi_pPDE </ci>
            </bvar>
            <apply>
              <times/>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> kdeg_cAMP </ci>
                  <ci> KD_IBMX </ci>
                </apply>
                <apply>
                  <plus/>
                  <ci> KD_IBMX </ci>
                  <ci> IBMX </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> PDE </ci>
                <apply>
                  <times/>
                  <ci> xi_pPDE </ci>
                  <ci> pPDE </ci>
                </apply>
              </apply>
              <ci> RIIp_cAMP_C_2 </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_2__reversible__3" name="function 2 (reversible)_3">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> RIIp_Rp_cAMPS_C_2 </ci>
            </bvar>
            <bvar>
              <ci> Rp_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <bvar>
              <ci> xi_KD </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> Rp_cAMPS </ci>
                <ci> RIIp_C_2 </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> KD_cAMP </ci>
                <ci> xi_KD </ci>
                <ci> RIIp_Rp_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="cAMP_degradation_3" name="cAMP degradation_3">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> IBMX </ci>
            </bvar>
            <bvar>
              <ci> KD_IBMX </ci>
            </bvar>
            <bvar>
              <ci> PDE </ci>
            </bvar>
            <bvar>
              <ci> RIIp_cAMP_2 </ci>
            </bvar>
            <bvar>
              <ci> kdeg_cAMP </ci>
            </bvar>
            <bvar>
              <ci> pPDE </ci>
            </bvar>
            <bvar>
              <ci> xi_pPDE </ci>
            </bvar>
            <apply>
              <times/>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> kdeg_cAMP </ci>
                  <ci> KD_IBMX </ci>
                </apply>
                <apply>
                  <plus/>
                  <ci> KD_IBMX </ci>
                  <ci> IBMX </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> PDE </ci>
                <apply>
                  <times/>
                  <ci> xi_pPDE </ci>
                  <ci> pPDE </ci>
                </apply>
              </apply>
              <ci> RIIp_cAMP_2 </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_2__reversible__1" name="function 2 (reversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
            </bvar>
            <bvar>
              <ci> Rp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <bvar>
              <ci> xi_KD </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> Rp8_Br_cAMPS </ci>
                <ci> RIIp_C_2 </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> KD_cAMP </ci>
                <ci> xi_KD </ci>
                <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_2__reversible__2" name="function 2 (reversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
            </bvar>
            <bvar>
              <ci> Rp8_pCPT_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <bvar>
              <ci> xi_KD </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> Rp8_pCPT_cAMPS </ci>
                <ci> RIIp_C_2 </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> KD_cAMP </ci>
                <ci> xi_KD </ci>
                <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_1__reversible__2" name="function 1 (reversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Csub </ci>
            </bvar>
            <bvar>
              <ci> Csub_H89 </ci>
            </bvar>
            <bvar>
              <ci> H89 </ci>
            </bvar>
            <bvar>
              <ci> KD </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> Csub </ci>
                <ci> kf </ci>
                <ci> H89 </ci>
              </apply>
              <apply>
                <times/>
                <ci> Csub_H89 </ci>
                <ci> KD </ci>
                <ci> kf </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="drug_flux__irreversible__2" name="drug flux (irreversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Rp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> Rp8_Br_cAMPS_pAB </ci>
            </bvar>
            <bvar>
              <ci> ki </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <apply>
              <times/>
              <ci> ki </ci>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> xi </ci>
                  <ci> Rp8_Br_cAMPS_pAB </ci>
                </apply>
                <ci> Rp8_Br_cAMPS </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="drug_flux__irreversible__1" name="drug flux (irreversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Sp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> Sp8_Br_cAMPS_AM </ci>
            </bvar>
            <bvar>
              <ci> ki </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <apply>
              <times/>
              <ci> ki </ci>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> xi </ci>
                  <ci> Sp8_Br_cAMPS_AM </ci>
                </apply>
                <ci> Sp8_Br_cAMPS </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="drug_flux__irreversible__4" name="drug flux (irreversible)_4">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Rp_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> Rp_cAMPS_pAB </ci>
            </bvar>
            <bvar>
              <ci> ki </ci>
            </bvar>
            <bvar>
              <ci> xi </ci>
            </bvar>
            <apply>
              <times/>
              <ci> ki </ci>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> xi </ci>
                  <ci> Rp_cAMPS_pAB </ci>
                </apply>
                <ci> Rp_cAMPS </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_1__reversible__1" name="function 1 (reversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> AC </ci>
            </bvar>
            <bvar>
              <ci> AC_Fsk </ci>
            </bvar>
            <bvar>
              <ci> Fsk </ci>
            </bvar>
            <bvar>
              <ci> KD_Fsk </ci>
            </bvar>
            <bvar>
              <ci> kf_Fsk </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> AC </ci>
                <ci> kf_Fsk </ci>
                <ci> Fsk </ci>
              </apply>
              <apply>
                <times/>
                <ci> AC_Fsk </ci>
                <ci> KD_Fsk </ci>
                <ci> kf_Fsk </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="Mass_action__two_parameters__irreversible__2" name="Mass action, two parameters (irreversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_cAMP_2 </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf_cAMP </ci>
              <ci> KD_cAMP </ci>
              <ci> RIIp_cAMP_2 </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4__irreversible__1" name="function 4 (irreversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_Sp8_Br_cAMPS_2 </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi_KD_Sp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> xi_b_Sp8_Br_cAMPS </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf_cAMP </ci>
              <ci> xi_b_Sp8_Br_cAMPS </ci>
              <ci> KD_cAMP </ci>
              <ci> xi_KD_Sp8_Br_cAMPS </ci>
              <ci> RIIp_Sp8_Br_cAMPS_2 </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_2__reversible__4" name="function 2 (reversible)_4">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> KD_cAMP </ci>
            </bvar>
            <bvar>
              <ci> RIIp_C_2 </ci>
            </bvar>
            <bvar>
              <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
            </bvar>
            <bvar>
              <ci> Sp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> kf_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi_KD_Sp8_Br_cAMPS </ci>
            </bvar>
            <bvar>
              <ci> xi_b_Sp8_Br_cAMPS </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi_b_Sp8_Br_cAMPS </ci>
                <ci> Sp8_Br_cAMPS </ci>
                <ci> RIIp_C_2 </ci>
              </apply>
              <apply>
                <times/>
                <ci> kf_cAMP </ci>
                <ci> xi_b_Sp8_Br_cAMPS </ci>
                <ci> xi_KD_Sp8_Br_cAMPS </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_6__irreversible__2" name="function 6 (irreversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> MOR_DAMGO </ci>
            </bvar>
            <bvar>
              <ci> alphaI_betaI_gammaI </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf </ci>
              <ci> MOR_DAMGO </ci>
              <ci> alphaI_betaI_gammaI </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="cAMP_production__irreversible___1__1" name="cAMP production (irreversible) [1]_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> AC </ci>
            </bvar>
            <bvar>
              <ci> AC_Fsk </ci>
            </bvar>
            <bvar>
              <ci> AC_alphaS_GTP </ci>
            </bvar>
            <bvar>
              <ci> ks_AC_cAMP </ci>
            </bvar>
            <bvar>
              <ci> xi_AC_cAMP_Fsk </ci>
            </bvar>
            <bvar>
              <ci> xi_AC_cAMP_alphaS_GTP </ci>
            </bvar>
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> ks_AC_cAMP </ci>
                <ci> AC </ci>
              </apply>
              <apply>
                <times/>
                <ci> ks_AC_cAMP </ci>
                <ci> xi_AC_cAMP_Fsk </ci>
                <ci> AC_alphaS_GTP </ci>
              </apply>
              <apply>
                <times/>
                <ci> ks_AC_cAMP </ci>
                <ci> xi_AC_cAMP_alphaS_GTP </ci>
                <ci> AC_Fsk </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_5__reversible__1" name="function 5 (reversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> DAMGO </ci>
            </bvar>
            <bvar>
              <ci> MOR </ci>
            </bvar>
            <bvar>
              <ci> MOR_DAMGO </ci>
            </bvar>
            <bvar>
              <ci> kb </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> MOR </ci>
                <ci> kf </ci>
                <ci> DAMGO </ci>
              </apply>
              <apply>
                <times/>
                <ci> MOR_DAMGO </ci>
                <ci> kb </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_5__reversible__2" name="function 5 (reversible)_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Fentanyl </ci>
            </bvar>
            <bvar>
              <ci> MOR </ci>
            </bvar>
            <bvar>
              <ci> MOR_Fentanyl </ci>
            </bvar>
            <bvar>
              <ci> kb </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> MOR </ci>
                <ci> kf </ci>
                <ci> Fentanyl </ci>
              </apply>
              <apply>
                <times/>
                <ci> MOR_Fentanyl </ci>
                <ci> kb </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_5__reversible__3" name="function 5 (reversible)_3">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> fiveHT </ci>
            </bvar>
            <bvar>
              <ci> fiveHT4 </ci>
            </bvar>
            <bvar>
              <ci> fiveHT4_5HT </ci>
            </bvar>
            <bvar>
              <ci> kb </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <minus/>
              <apply>
                <times/>
                <ci> fiveHT4 </ci>
                <ci> kf </ci>
                <ci> fiveHT </ci>
              </apply>
              <apply>
                <times/>
                <ci> fiveHT4_5HT </ci>
                <ci> kb </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_6__irreversible__1" name="function 6 (irreversible)_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> alphaS_betaS_gammaS </ci>
            </bvar>
            <bvar>
              <ci> fiveHT4_5HT </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf </ci>
              <ci> fiveHT4_5HT </ci>
              <ci> alphaS_betaS_gammaS </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_6__irreversible__3" name="function 6 (irreversible)_3">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> MOR_Fentanyl </ci>
            </bvar>
            <bvar>
              <ci> alphaI_betaI_gammaI </ci>
            </bvar>
            <bvar>
              <ci> kf </ci>
            </bvar>
            <apply>
              <times/>
              <ci> kf </ci>
              <ci> MOR_Fentanyl </ci>
              <ci> alphaI_betaI_gammaI </ci>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
    </listOfFunctionDefinitions>
    <listOfUnitDefinitions>
      <unitDefinition id="volume" name="volume">
        <listOfUnits>
          <unit kind="litre" exponent="1" scale="-12" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="time" name="time">
        <listOfUnits>
          <unit kind="second" exponent="1" scale="0" multiplier="3600"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="substance" name="substance">
        <listOfUnits>
          <unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment metaid="cytosol_meta" id="cytosol" name="cytosol" spatialDimensions="3" size="1" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#cytosol_meta">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0005829"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#cytosol_meta">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0005829"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </compartment>
    </listOfCompartments>
    <listOfSpecies>
      <species metaid="COPASI1" id="AC_Fsk" name="AC_Fsk" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI1">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/D4A3N4"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI1">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/D4A3N4"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI2" id="cAMP" name="cAMP" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI2">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.chebi/CHEBI%3A17489"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI2">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI3" id="Csub" name="Csub" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI3">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI3">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI4" id="Csub_H89" name="Csub_H89" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI4">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL104264"/>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI4">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL104264"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI5" id="RIIp_C_2" name="RIIp_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI5">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI5">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasVersion>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI6" id="RIIp_cAMP_C_2" name="RIIp_cAMP_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI6">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.chebi/CHEBI%3A17489"/>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI6">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasVersion>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI7" id="RIIp_cAMP_2" name="RIIp_cAMP_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI7">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.chebi/CHEBI%3A17489"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI7">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasVersion>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI8" id="Sp8_Br_cAMPS" name="Sp8_Br_cAMPS" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI8">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/9802422"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI8">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/9802422"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI9" id="Rp8_Br_cAMPS" name="Rp8_Br_cAMPS" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI9">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/16760258"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
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          </rdf:RDF>
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      <species metaid="COPASI10" id="Rp8_pCPT_cAMPS" name="Rp8_pCPT_cAMPS" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
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              </bqbiol:is>
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          </rdf:RDF>
        </annotation>
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      <species metaid="COPASI11" id="Rp_cAMPS" name="Rp_cAMPS" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
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          <COPASI xmlns="http://www.copasi.org/static/sbml">
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            </rdf:RDF>
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          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI11">
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          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI12" id="RIIp_Rp8_Br_cAMPS_C_2" name="RIIp_Rp8_Br_cAMPS_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
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                <CopasiMT:hasVersion>
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          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI13" id="RIIp_Rp8_pCPT_cAMPS_C_2" name="RIIp_Rp8_pCPT_cAMPS_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
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              <rdf:Description rdf:about="#COPASI13">
                <CopasiMT:hasPart>
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                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/101244611"/>
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                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
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                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI13">
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              <bqbiol:hasPart>
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                </rdf:Bag>
              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI14" id="RIIp_Rp_cAMPS_C_2" name="RIIp_Rp_cAMPS_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
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              <rdf:Description rdf:about="#COPASI14">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/16072219"/>
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                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
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                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
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            <rdf:Description rdf:about="#COPASI14">
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              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
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              </bqbiol:hasPart>
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                </rdf:Bag>
              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
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      <species metaid="COPASI15" id="RIIp_Sp8_Br_cAMPS_C_2" name="RIIp_Sp8_Br_cAMPS_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
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              <rdf:Description rdf:about="#COPASI15">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/9802422"/>
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                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:isVersionOf>
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            </rdf:RDF>
          </COPASI>
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            <rdf:Description rdf:about="#COPASI15">
              <bqbiol:hasPart>
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              </bqbiol:hasPart>
              <bqbiol:hasPart>
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              </bqbiol:isVersionOf>
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          </rdf:RDF>
        </annotation>
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        <annotation>
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              <rdf:Description rdf:about="#COPASI16">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/9802422"/>
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                </CopasiMT:hasPart>
                <CopasiMT:hasVersion>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
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                </CopasiMT:hasVersion>
              </rdf:Description>
            </rdf:RDF>
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          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI16">
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                  <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/9802422"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasVersion>
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              </bqbiol:hasVersion>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI17" id="RIIp_2" name="RIIp_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
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              <rdf:Description rdf:about="#COPASI17">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI17">
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              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI18" id="RII_2" name="RII_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
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              <rdf:Description rdf:about="#COPASI18">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
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                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI18">
              <bqbiol:is>
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              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI19" id="IBMX" name="IBMX" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
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              <rdf:Description rdf:about="#COPASI19">
                <dcterms:created>
                  <rdf:Description>
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                </dcterms:created>
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL275084"/>
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                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI19">
              <bqbiol:is>
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              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI20" id="PDE" name="PDE" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
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              <rdf:Description rdf:about="#COPASI20">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q9GQU6"/>
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                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI20">
              <bqbiol:is>
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              </bqbiol:is>
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          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI21" id="pPDE" name="pPDE" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
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              <rdf:Description rdf:about="#COPASI21">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q9GQU6"/>
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                </CopasiMT:isVersionOf>
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            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI21">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q9GQU6"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI22" id="AC" name="AC" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI22">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-10-08T08:11:57Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI22">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="COPASI36" id="RII_C_2" name="RII_C_2" compartment="cytosol" initialConcentration="0" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI36">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI36">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05759"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter metaid="COPASI38" id="Fsk" name="Fsk" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI38">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI38">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL52606"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI41" id="NTX" name="NTX" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI41">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.chebi/CHEBI%3A7465"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI41">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:7465"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI42" id="CTOP" name="CTOP" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI42">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/90479805"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI42">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/90479805"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI43" id="IBMXex" name="IBMXex" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI43">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL275084"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI43">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL275084"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI44" id="DMSO" name="DMSO" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI44">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL504"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI44">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL504"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI45" id="H89" name="H89" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI45">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL104264"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI45">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL104264"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI46" id="Rp8_Br_cAMPS_pAB" name="Rp8_Br_cAMPS_pAB" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI46">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-26T18:48:34Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI47" id="Rp8_pCPT_cAMPS_pAB" name="Rp8_pCPT_cAMPS_pAB" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI47">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-26T18:48:37Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI48" id="Rp_cAMPS_pAB" name="Rp_cAMPS_pAB" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI48">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-26T18:48:39Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI49" id="fourABnOH" name="fourABnOH" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI49">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-26T18:48:44Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="kf_Fsk" name="kf_Fsk" value="0" constant="true"/>
      <parameter id="KD_Fsk" name="KD_Fsk" value="0" constant="true"/>
      <parameter id="kp_AC" name="kp_AC" value="0" constant="true"/>
      <parameter metaid="COPASI50" id="kdp_AC" name="kdp_AC" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI50">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-21T15:31:29Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="kf_cAMP" name="kf_cAMP" value="0" constant="true"/>
      <parameter id="kf_RIIp_cAMP_C_2__RIIp_2" name="kf_RIIp_cAMP_C_2__RIIp_2" value="0" constant="true"/>
      <parameter metaid="COPASI51" id="kdeg_cAMP" name="kdeg_cAMP" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI51">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-21T15:31:28Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="KD_IBMX" name="KD_IBMX" value="0" constant="true"/>
      <parameter id="xi_pPDE" name="xi_pPDE" value="0" constant="true"/>
      <parameter metaid="COPASI52" id="KD_cAMP" name="KD_cAMP" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI52">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-09-28T14:34:18Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="xi_b_Sp8_Br_cAMPS" name="xi_b_Sp8_Br_cAMPS" value="0" constant="true"/>
      <parameter id="xi_KD_Sp8_Br_cAMPS" name="xi_KD_Sp8_Br_cAMPS" value="0" constant="true"/>
      <parameter metaid="COPASI53" id="AC_total" name="AC_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI53">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/D4A3N4"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI53">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/D4A3N4"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI54" id="RII2_total" name="RII2_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI54">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI54">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI55" id="PDE_total" name="PDE_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI55">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q9GQU6"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI55">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q9GQU6"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI56" id="pRII_western" name="pRII_western" value="0" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI56">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI56">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI57" id="Sp8_Br_cAMPS_AM" name="Sp8_Br_cAMPS_AM" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI57">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-12-26T18:48:27Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI58" id="fiveHT_time_0" name="fiveHT_time" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI58">
                <bqbiol:isPropertyOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL39"/>
                  </rdf:Bag>
                </bqbiol:isPropertyOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI58">
              <bqbiol:isPropertyOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL39"/>
                </rdf:Bag>
              </bqbiol:isPropertyOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI59" id="fiveHT_level_0" name="fiveHT_level" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI59">
                <bqbiol:isPropertyOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL39"/>
                  </rdf:Bag>
                </bqbiol:isPropertyOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI59">
              <bqbiol:isPropertyOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chembl.compound/CHEMBL39"/>
                </rdf:Bag>
              </bqbiol:isPropertyOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI60" id="pRII" name="pRII" value="0" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI60">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI60">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P12369"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI61" id="fiveHT4_total" name="fiveHT4_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI61">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q62758"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI61">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q62758"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="COPASI62" id="MOR_total" name="MOR_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI62">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P33535"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI62">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P33535"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="alphaS_betaS_gammaS_total_meta" id="alphaS_betaS_gammaS_total" name="alphaS_betaS_gammaS_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#alphaS_betaS_gammaS_total_meta">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P30951"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#alphaS_betaS_gammaS_total_meta">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P30951"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter metaid="alphaI_betaI_gammaI_total_meta" id="alphaI_betaI_gammaI_total" name="alphaI_betaI_gammaI_total" value="0" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#alphaI_betaI_gammaI_total_meta">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/P30951"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#alphaI_betaI_gammaI_total_meta">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P30951"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </parameter>
      <parameter id="ks_AC_cAMP" name="ks_AC_cAMP" value="0" constant="true"/>
      <parameter id="kf_RII_C_2__RII_2" name="kf_RII_C_2__RII_2" value="0" constant="true"/>
      <parameter id="kf_RII_2__RII_C_2" name="kf_RII_2__RII_C_2" value="0" constant="true"/>
      <parameter id="rel_open" name="rel_open" value="0" constant="true"/>
      <parameter id="xi_rel_open" name="xi_rel_open" value="0" constant="true"/>
      <parameter metaid="COPASI63" id="Calpha" name="Calpha" value="0" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI63">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-21T14:17:53Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
    </listOfParameters>
    <listOfInitialAssignments>
      <initialAssignment symbol="RIIp_C_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> RII2_total </ci>
        </math>
      </initialAssignment>
      <initialAssignment symbol="PDE">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> PDE_total </ci>
        </math>
      </initialAssignment>
      <initialAssignment symbol="AC">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> AC_total </ci>
        </math>
      </initialAssignment>
    </listOfInitialAssignments>
    <listOfRules>
      <assignmentRule variable="pRII">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_cAMP_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Sp8_Br_cAMPS_2 </ci>
            </apply>
            <apply>
              <times/>
              <ci> rel_open </ci>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <ci> RIIp_C_2 </ci>
                </apply>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
                </apply>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
                </apply>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <ci> RIIp_Rp_cAMPS_C_2 </ci>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <apply>
                <plus/>
                <ci> rel_open </ci>
                <apply>
                  <times/>
                  <ci> xi_rel_open </ci>
                  <apply>
                    <minus/>
                    <cn> 1 </cn>
                    <ci> rel_open </ci>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> RIIp_cAMP_C_2 </ci>
                <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule variable="pRII_western">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_C_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_cAMP_C_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_cAMP_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Sp8_Br_cAMPS_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> RIIp_Rp_cAMPS_C_2 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule variable="Calpha">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> rel_open </ci>
              <apply>
                <plus/>
                <ci> RIIp_C_2 </ci>
                <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
                <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
                <ci> RIIp_Rp_cAMPS_C_2 </ci>
              </apply>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <apply>
                <plus/>
                <ci> rel_open </ci>
                <apply>
                  <times/>
                  <ci> xi_rel_open </ci>
                  <apply>
                    <minus/>
                    <cn> 1 </cn>
                    <ci> rel_open </ci>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> RIIp_cAMP_C_2 </ci>
                <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </assignmentRule>
    </listOfRules>
    <listOfReactions>
      <reaction metaid="COPASI64" id="AC___AC_Fsk" name="AC = AC_Fsk" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI64">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0065003"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI64">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0065003"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="AC" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="AC_Fsk" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_1__reversible__1 </ci>
                <ci> AC </ci>
                <ci> AC_Fsk </ci>
                <ci> Fsk </ci>
                <ci> KD_Fsk </ci>
                <ci> kf_Fsk </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI65" id="Sp8_Br_cAMPS_0" name="Sp8_Br_cAMPS" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI65">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0055085"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI65">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0055085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Sp8_Br_cAMPS" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> drug_flux__irreversible__1 </ci>
                <ci> Sp8_Br_cAMPS </ci>
                <ci> Sp8_Br_cAMPS_AM </ci>
                <ci> ki </ci>
                <ci> xi </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ki" name="ki" value="0.1"/>
            <parameter id="xi" name="xi" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI66" id="Rp8_Br_cAMPS_0" name="Rp8_Br_cAMPS" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI66">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0055085"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI66">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0055085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Rp8_Br_cAMPS" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> drug_flux__irreversible__2 </ci>
                <ci> Rp8_Br_cAMPS </ci>
                <ci> Rp8_Br_cAMPS_pAB </ci>
                <ci> ki </ci>
                <ci> xi </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ki" name="ki" value="0.1"/>
            <parameter id="xi" name="xi" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI67" id="Rp8_pCPT_cAMPS_0" name="Rp8_pCPT_cAMPS" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI67">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0055085"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI67">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0055085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Rp8_pCPT_cAMPS" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> drug_flux__irreversible__3 </ci>
                <ci> Rp8_pCPT_cAMPS </ci>
                <ci> Rp8_pCPT_cAMPS_pAB </ci>
                <ci> ki </ci>
                <ci> xi </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ki" name="ki" value="0.1"/>
            <parameter id="xi" name="xi" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI68" id="Rp_cAMPS_0" name="Rp_cAMPS" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI68">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0055085"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI68">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0055085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Rp_cAMPS" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> drug_flux__irreversible__4 </ci>
                <ci> Rp_cAMPS </ci>
                <ci> Rp_cAMPS_pAB </ci>
                <ci> ki </ci>
                <ci> xi </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ki" name="ki" value="0.1"/>
            <parameter id="xi" name="xi" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI69" id="IBMX_0" name="IBMX" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI69">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0055085"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI69">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0055085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="IBMX" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> IBMX_flux_1 </ci>
                <ci> IBMX </ci>
                <ci> IBMXex </ci>
                <ci> ki </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ki" name="ki" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI70" id="Csub___Csub_H89" name="Csub = Csub_H89" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI70">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0065003"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI70">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0065003"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Csub_H89" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_1__reversible__2 </ci>
                <ci> Csub </ci>
                <ci> Csub_H89 </ci>
                <ci> H89 </ci>
                <ci> KD </ci>
                <ci> kf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="KD" name="KD" value="0.1"/>
            <parameter id="kf" name="kf" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI71" id="RIIp_C_2___RIIp_Rp8_Br_cAMPS_C_2" name="RIIp_C_2 = RIIp_Rp8_Br_cAMPS_C_2" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI71">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0065003"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI71">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0065003"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_Rp8_Br_cAMPS_C_2" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Rp8_Br_cAMPS"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_2__reversible__1 </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_C_2 </ci>
                <ci> RIIp_Rp8_Br_cAMPS_C_2 </ci>
                <ci> Rp8_Br_cAMPS </ci>
                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> xi_KD </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="xi" name="xi" value="0.1"/>
            <parameter id="xi_KD" name="xi_KD" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI72" id="RIIp_C_2___RIIp_Rp8_pCPT_cAMPS_C_2" name="RIIp_C_2 = RIIp_Rp8_pCPT_cAMPS_C_2" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI72">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0065003"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI72">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0065003"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_Rp8_pCPT_cAMPS_C_2" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Rp8_pCPT_cAMPS"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_2__reversible__2 </ci>
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                <ci> RIIp_C_2 </ci>
                <ci> RIIp_Rp8_pCPT_cAMPS_C_2 </ci>
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                <ci> kf_cAMP </ci>
                <ci> xi </ci>
                <ci> xi_KD </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="xi" name="xi" value="0.1"/>
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          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI73" id="RIIp_C_2___RIIp_Rp_cAMPS_C_2" name="RIIp_C_2 = RIIp_Rp_cAMPS_C_2" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI73">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
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                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI73">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
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              <bqbiol:is>
                <rdf:Bag>
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              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
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        <listOfProducts>
          <speciesReference species="RIIp_Rp_cAMPS_C_2" stoichiometry="1"/>
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        <listOfModifiers>
          <modifierSpeciesReference species="Rp_cAMPS"/>
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        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_2__reversible__3 </ci>
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                <ci> xi </ci>
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              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="xi" name="xi" value="0.1"/>
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        </kineticLaw>
      </reaction>
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        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI74">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
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                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
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          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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                <rdf:Bag>
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              <bqbiol:is>
                <rdf:Bag>
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              </bqbiol:is>
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        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
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        <listOfProducts>
          <speciesReference species="RIIp_Sp8_Br_cAMPS_C_2" stoichiometry="1"/>
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        <listOfModifiers>
          <modifierSpeciesReference species="Sp8_Br_cAMPS"/>
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        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_2__reversible__4 </ci>
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                <ci> xi_KD_Sp8_Br_cAMPS </ci>
                <ci> xi_b_Sp8_Br_cAMPS </ci>
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          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI75" id="RIIp_Sp8_Br_cAMPS_C_2____RIIp_Sp8_Br_cAMPS_2___Csub" name="RIIp_Sp8_Br_cAMPS_C_2 -&gt; RIIp_Sp8_Br_cAMPS_2 + Csub" reversible="false">
        <annotation>
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                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
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                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI75">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_Sp8_Br_cAMPS_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_Sp8_Br_cAMPS_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> kf_RIIp_cAMP_C_2__RIIp_2 </ci>
              <ci> RIIp_Sp8_Br_cAMPS_C_2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI76" id="RIIp_cAMP_C_2_____RIIp_cAMP_2___Csub" name="RIIp_cAMP_C_2  -&gt; RIIp_cAMP_2 + Csub" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI76">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI76">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_cAMP_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_cAMP_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> kf_RIIp_cAMP_C_2__RIIp_2 </ci>
              <ci> RIIp_cAMP_C_2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI77" id="RIIp_C_2_____RIIp_2___Csub" name="RIIp_C_2  -&gt; RIIp_2 + Csub" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI77">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0043624"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI77">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0043624"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> Mass_action__two_parameters__irreversible__1 </ci>
                <ci> RIIp_C_2 </ci>
                <ci> k2 </ci>
                <ci> kf_RII_C_2__RII_2 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k2" name="k2" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI78" id="RIIp_2____RII_2" name="RIIp_2 -&gt; RII_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI78">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006470"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI78">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RII_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> k1 </ci>
              <ci> RIIp_2 </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" name="k1" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI79" id="PDE___pPDE" name="PDE = pPDE" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI79">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006468"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006470"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI79">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006468"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="PDE" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="pPDE" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Csub"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_3__reversible__1 </ci>
                <ci> Csub </ci>
                <ci> KD </ci>
                <ci> PDE </ci>
                <ci> kf </ci>
                <ci> pPDE </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="KD" name="KD" value="0.1"/>
            <parameter id="kf" name="kf" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI80" id="RIIp_C_2___RIIp_cAMP_C_2" name="RIIp_C_2 = RIIp_cAMP_C_2" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI80">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006198"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI80">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006198"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_cAMP_C_2" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="cAMP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_3__reversible__2 </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_C_2 </ci>
                <ci> RIIp_cAMP_C_2 </ci>
                <ci> cAMP </ci>
                <ci> kf_cAMP </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI81" id="cAMP__" name="cAMP -&gt;" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI81">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006198"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI81">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006198"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="cAMP" stoichiometry="1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference species="IBMX"/>
          <modifierSpeciesReference species="PDE"/>
          <modifierSpeciesReference species="pPDE"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> cAMP_degradation_1 </ci>
                <ci> IBMX </ci>
                <ci> KD_IBMX </ci>
                <ci> PDE </ci>
                <ci> cAMP </ci>
                <ci> kdeg_cAMP </ci>
                <ci> pPDE </ci>
                <ci> xi_pPDE </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI82" id="RIIp_cAMP_C_2____RIIp_C_2" name="RIIp_cAMP_C_2 -&gt; RIIp_C_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI82">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006198"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI82">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006198"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_cAMP_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="IBMX"/>
          <modifierSpeciesReference species="PDE"/>
          <modifierSpeciesReference species="pPDE"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> cAMP_degradation_2 </ci>
                <ci> IBMX </ci>
                <ci> KD_IBMX </ci>
                <ci> PDE </ci>
                <ci> RIIp_cAMP_C_2 </ci>
                <ci> kdeg_cAMP </ci>
                <ci> pPDE </ci>
                <ci> xi_pPDE </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI83" id="RIIp_cAMP_2____RIIp_2" name="RIIp_cAMP_2 -&gt; RIIp_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI83">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006198"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI83">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006198"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_cAMP_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="IBMX"/>
          <modifierSpeciesReference species="PDE"/>
          <modifierSpeciesReference species="pPDE"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> cAMP_degradation_3 </ci>
                <ci> IBMX </ci>
                <ci> KD_IBMX </ci>
                <ci> PDE </ci>
                <ci> RIIp_cAMP_2 </ci>
                <ci> kdeg_cAMP </ci>
                <ci> pPDE </ci>
                <ci> xi_pPDE </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI84" id="RIIp_cAMP_2____RIIp_2__2" name="RIIp_cAMP_2 -&gt; RIIp_2, 2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI84">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006198"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI84">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006198"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_cAMP_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> Mass_action__two_parameters__irreversible__2 </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_cAMP_2 </ci>
                <ci> kf_cAMP </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI85" id="RIIp_Sp8_Br_cAMPS_2____RIIp_2" name="RIIp_Sp8_Br_cAMPS_2 -&gt; RIIp_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI85">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0032984"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI85">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0032984"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_Sp8_Br_cAMPS_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_4__irreversible__1 </ci>
                <ci> KD_cAMP </ci>
                <ci> RIIp_Sp8_Br_cAMPS_2 </ci>
                <ci> kf_cAMP </ci>
                <ci> xi_KD_Sp8_Br_cAMPS </ci>
                <ci> xi_b_Sp8_Br_cAMPS </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI104" id="RII_2___Csub____RII_C_2" name="RII_2 + Csub -&gt; RII_C_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI104">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0034236"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0065003"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI104">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0034236"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0065003"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RII_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RII_C_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> kf_RII_2__RII_C_2 </ci>
              <ci> RII_2 </ci>
              <ci> Csub </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI105" id="RII_C_2____RII_2___Csub" name="RII_C_2 -&gt; RII_2 + Csub" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI105">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0043624"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI105">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0043624"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RII_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RII_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> kf_RII_C_2__RII_2 </ci>
              <ci> RII_C_2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI106" id="RII_C_2___RIIp_C_2" name="RII_C_2 = RIIp_C_2" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI106">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006468"/>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0006470"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI106">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006468"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:hasPart>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RII_C_2" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> k1 </ci>
                  <ci> RII_C_2 </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> k2 </ci>
                  <ci> RIIp_C_2 </ci>
                </apply>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" name="k1" value="0.1"/>
            <parameter id="k2" name="k2" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="COPASI107" id="RIIp_2___Csub_____RIIp_C_2" name="RIIp_2 + Csub  -&gt; RIIp_C_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI107">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0034236"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isPartOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/obo.go/GO%3A0010737"/>
                  </rdf:Bag>
                </CopasiMT:isPartOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI107">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0034236"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:isPartOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/go/GO:0010737"/>
                </rdf:Bag>
              </bqbiol:isPartOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="RIIp_2" stoichiometry="1"/>
          <speciesReference species="Csub" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RIIp_C_2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <ci> function_7__irreversible__1 </ci>
                <ci> Csub </ci>
                <ci> RIIp_2 </ci>
                <ci> kf_RII_2__RII_C_2 </ci>
                <ci> xi </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="xi" name="xi" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>