diff --git a/Formula/p/python-charset-normalizer.rb b/Formula/p/python-charset-normalizer.rb
index e8a6a06f28b2a..d6f0e38e069d9 100644
--- a/Formula/p/python-charset-normalizer.rb
+++ b/Formula/p/python-charset-normalizer.rb
@@ -15,7 +15,8 @@ class PythonCharsetNormalizer < Formula
     sha256 cellar: :any_skip_relocation, x86_64_linux:   "8c94c6c9984fe7b9e2c079e855886199ba04896fc608f43949bbeda964097949"
   end
 
-  depends_on "python-setuptools" => :build
+  deprecate! date: "2024-03-14", because: "does not meet homebrew/core's requirements for Python library formulae"
+
   depends_on "python@3.11" => [:build, :test]
   depends_on "python@3.12" => [:build, :test]
 
@@ -26,10 +27,19 @@ def pythons
   def install
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
-      system python_exe, "-m", "pip", "install", *std_pip_args, "."
+      system python_exe, "-m", "pip", "install", *std_pip_args(build_isolation: true), "."
     end
   end
 
+  def caveats
+    <<~EOS
+      Additional details on upcoming formula removal are available at:
+      * https://github.com/Homebrew/homebrew-core/issues/157500
+      * https://docs.brew.sh/Python-for-Formula-Authors#libraries
+      * https://docs.brew.sh/Homebrew-and-Python#pep-668-python312-and-virtual-environments
+    EOS
+  end
+
   test do
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
diff --git a/Formula/p/python-idna.rb b/Formula/p/python-idna.rb
index d0f68b397462e..93920417235ea 100644
--- a/Formula/p/python-idna.rb
+++ b/Formula/p/python-idna.rb
@@ -15,7 +15,8 @@ class PythonIdna < Formula
     sha256 cellar: :any_skip_relocation, x86_64_linux:   "8efe129e5a958477ceddfe5f1a6fa039924b4811a7315f2052b39d99eb27dc8e"
   end
 
-  depends_on "python-flit-core" => :build
+  deprecate! date: "2024-03-14", because: "does not meet homebrew/core's requirements for Python library formulae"
+
   depends_on "python@3.11" => [:build, :test]
   depends_on "python@3.12" => [:build, :test]
 
@@ -26,10 +27,19 @@ def pythons
   def install
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
-      system python_exe, "-m", "pip", "install", *std_pip_args, "."
+      system python_exe, "-m", "pip", "install", *std_pip_args(build_isolation: true), "."
     end
   end
 
+  def caveats
+    <<~EOS
+      Additional details on upcoming formula removal are available at:
+      * https://github.com/Homebrew/homebrew-core/issues/157500
+      * https://docs.brew.sh/Python-for-Formula-Authors#libraries
+      * https://docs.brew.sh/Homebrew-and-Python#pep-668-python312-and-virtual-environments
+    EOS
+  end
+
   test do
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
diff --git a/Formula/p/python-requests.rb b/Formula/p/python-requests.rb
index b23a04bd79153..b5e773111be73 100644
--- a/Formula/p/python-requests.rb
+++ b/Formula/p/python-requests.rb
@@ -15,7 +15,8 @@ class PythonRequests < Formula
     sha256 cellar: :any_skip_relocation, x86_64_linux:   "38eb54a3c08da5790c7da2dbbe36992772214a7bf2ce87a73b5f58930ec7b0a8"
   end
 
-  depends_on "python-setuptools" => :build
+  deprecate! date: "2024-03-14", because: "does not meet homebrew/core's requirements for Python library formulae"
+
   depends_on "python@3.11" => [:build, :test]
   depends_on "python@3.12" => [:build, :test]
   depends_on "certifi"
@@ -30,10 +31,19 @@ def pythons
   def install
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
-      system python_exe, "-m", "pip", "install", *std_pip_args, "."
+      system python_exe, "-m", "pip", "install", *std_pip_args(build_isolation: true), "."
     end
   end
 
+  def caveats
+    <<~EOS
+      Additional details on upcoming formula removal are available at:
+      * https://github.com/Homebrew/homebrew-core/issues/157500
+      * https://docs.brew.sh/Python-for-Formula-Authors#libraries
+      * https://docs.brew.sh/Homebrew-and-Python#pep-668-python312-and-virtual-environments
+    EOS
+  end
+
   test do
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
diff --git a/Formula/p/python-urllib3.rb b/Formula/p/python-urllib3.rb
index e70ecd1851e38..62a2b9634fffd 100644
--- a/Formula/p/python-urllib3.rb
+++ b/Formula/p/python-urllib3.rb
@@ -15,7 +15,8 @@ class PythonUrllib3 < Formula
     sha256 cellar: :any_skip_relocation, x86_64_linux:   "a93d805dc32d35932eeb16e26b24bf513e53815cea88aada3d5da426bf91fa07"
   end
 
-  depends_on "python-hatchling" => :build
+  deprecate! date: "2024-03-14", because: "does not meet homebrew/core's requirements for Python library formulae"
+
   depends_on "python@3.11" => [:build, :test]
   depends_on "python@3.12" => [:build, :test]
 
@@ -26,10 +27,19 @@ def pythons
   def install
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"
-      system python_exe, "-m", "pip", "install", *std_pip_args, "."
+      system python_exe, "-m", "pip", "install", *std_pip_args(build_isolation: true), "."
     end
   end
 
+  def caveats
+    <<~EOS
+      Additional details on upcoming formula removal are available at:
+      * https://github.com/Homebrew/homebrew-core/issues/157500
+      * https://docs.brew.sh/Python-for-Formula-Authors#libraries
+      * https://docs.brew.sh/Homebrew-and-Python#pep-668-python312-and-virtual-environments
+    EOS
+  end
+
   test do
     pythons.each do |python|
       python_exe = python.opt_libexec/"bin/python"