diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 8cc71ceb86325..59a1813610ff9 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -3559,6 +3559,11 @@
 //
 //#define M100_FREE_MEMORY_WATCHER
 
+//
+// M42 - Set pin states
+//
+//#define DIRECT_PIN_CONTROL
+
 //
 // M43 - display pin status, toggle pins, watch pins, watch endstops & toggle LED, test servo probe
 //
diff --git a/Marlin/src/gcode/control/M226.cpp b/Marlin/src/gcode/control/M226.cpp
index 52e0e57a87f07..0ab89644dd9ed 100644
--- a/Marlin/src/gcode/control/M226.cpp
+++ b/Marlin/src/gcode/control/M226.cpp
@@ -20,6 +20,10 @@
  *
  */
 
+#include "../../MarlinConfig.h"
+
+#if ENABLED(DIRECT_PIN_CONTROL)
+
 #include "../gcode.h"
 #include "../../MarlinCore.h" // for pin_is_protected and idle()
 #include "../../module/stepper.h"
@@ -50,3 +54,5 @@ void GcodeSuite::M226() {
     } // pin_state -1 0 1 && pin > -1
   } // parser.seen('P')
 }
+
+#endif // DIRECT_PIN_CONTROL
diff --git a/Marlin/src/gcode/control/M42.cpp b/Marlin/src/gcode/control/M42.cpp
index c88113db49df0..c635c06ec63bd 100644
--- a/Marlin/src/gcode/control/M42.cpp
+++ b/Marlin/src/gcode/control/M42.cpp
@@ -20,9 +20,12 @@
  *
  */
 
+#include "../../inc/MarlinConfig.h"
+
+#if ENABLED(DIRECT_PIN_CONTROL)
+
 #include "../gcode.h"
 #include "../../MarlinCore.h" // for pin_is_protected
-#include "../../inc/MarlinConfig.h"
 
 #if HAS_FAN
   #include "../../module/temperature.h"
@@ -96,3 +99,5 @@ void GcodeSuite::M42() {
   extDigitalWrite(pin, pin_status);
   analogWrite(pin, pin_status);
 }
+
+#endif // DIRECT_PIN_CONTROL
diff --git a/Marlin/src/gcode/gcode.cpp b/Marlin/src/gcode/gcode.cpp
index 1de54259beb78..c93d5c6e888d0 100644
--- a/Marlin/src/gcode/gcode.cpp
+++ b/Marlin/src/gcode/gcode.cpp
@@ -445,7 +445,10 @@ void GcodeSuite::process_parsed_command(const bool no_ok/*=false*/) {
       #endif // SDSUPPORT
 
       case 31: M31(); break;                                      // M31: Report time since the start of SD print or last M109
-      case 42: M42(); break;                                      // M42: Change pin state
+
+      #if ENABLED(DIRECT_PIN_CONTROL)
+        case 42: M42(); break;                                    // M42: Change pin state
+      #endif
 
       #if ENABLED(PINS_DEBUGGING)
         case 43: M43(); break;                                    // M43: Read pin state
diff --git a/Marlin/src/gcode/gcode.h b/Marlin/src/gcode/gcode.h
index 026083bcfc7ba..53ec07b15a8ed 100644
--- a/Marlin/src/gcode/gcode.h
+++ b/Marlin/src/gcode/gcode.h
@@ -109,7 +109,7 @@
  *        The '#' is necessary when calling from within sd files, as it stops buffer prereading
  * M33  - Get the longname version of a path. (Requires LONG_FILENAME_HOST_SUPPORT)
  * M34  - Set SD Card sorting options. (Requires SDCARD_SORT_ALPHA)
- * M42  - Change pin status via gcode: M42 P<pin> S<value>. LED pin assumed if P is omitted.
+ * M42  - Change pin status via gcode: M42 P<pin> S<value>. LED pin assumed if P is omitted. (Requires DIRECT_PIN_CONTROL)
  * M43  - Display pin status, watch pins for changes, watch endstops & toggle LED, Z servo probe test, toggle pins
  * M48  - Measure Z Probe repeatability: M48 P<points> X<pos> Y<pos> V<level> E<engage> L<legs> S<chizoid>. (Requires Z_MIN_PROBE_REPEATABILITY_TEST)
  * M73  - Set the progress percentage. (Requires LCD_SET_PROGRESS_MANUALLY)
@@ -541,8 +541,7 @@ class GcodeSuite {
     #endif
   #endif
 
-  static void M42();
-
+  TERN_(DIRECT_PIN_CONTROL, static void M42());
   TERN_(PINS_DEBUGGING, static void M43());
 
   TERN_(Z_MIN_PROBE_REPEATABILITY_TEST, static void M48());
diff --git a/platformio.ini b/platformio.ini
index 4628baec9a2fc..ea94fa04a7155 100644
--- a/platformio.ini
+++ b/platformio.ini
@@ -119,6 +119,7 @@ default_src_filter = +<src/*> -<src/config> -<src/HAL> +<src/HAL/shared>
   -<src/gcode/calibrate/M425.cpp>
   -<src/gcode/calibrate/M666.cpp>
   -<src/gcode/calibrate/M852.cpp>
+  -<src/gcode/control/M42.cpp> -<src/gcode/control/M226.cpp>
   -<src/gcode/config/M43.cpp>
   -<src/gcode/config/M217.cpp>
   -<src/gcode/config/M218.cpp>
@@ -321,6 +322,7 @@ BACKLASH_GCODE          = src_filter=+<src/gcode/calibrate/M425.cpp>
 IS_KINEMATIC            = src_filter=+<src/gcode/calibrate/M665.cpp>
 HAS_EXTRA_ENDSTOPS      = src_filter=+<src/gcode/calibrate/M666.cpp>
 SKEW_CORRECTION_GCODE   = src_filter=+<src/gcode/calibrate/M852.cpp>
+DIRECT_PIN_CONTROL      = src_filter=+<src/gcode/control/M42.cpp> +<src/gcode/control/M226.cpp>
 PINS_DEBUGGING          = src_filter=+<src/gcode/config/M43.cpp>
 NO_VOLUMETRICS          = src_filter=-<src/gcode/config/M200-M205.cpp>
 HAS_MULTI_EXTRUDER      = src_filter=+<src/gcode/config/M217.cpp>