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Conversion to NeuroML

To run this code:

nrnivmodl ../NEURON/channels/
python export_nml2.py

After conversion to NeuroML

Notebook to create multicompartmental cell here

After running the multicompartmental cell LEMS file:

Membrane potential for 0.4nA pulse for a duration of 500ms with a delay of 100ms

Optimization of the dendritic calcium dynamics and somato-dendritic coupling for varying current injections into the soma and the dendrite

Interactive notebook that creates the following plots here

Note: After the parameters are reset run nrnivmodl each time inside this directory to compile the mod files to regenerate the results

(b) A small EPSP shaped dendritic current injection does not lead to spiking

Somatic current = 0.8nA, Pulse duration = 5ms

(c) A somatic current pulse elicits a single somatic spike that back-propagates into the dendrite without crossing the threshold for the initiation of dendritic calcium APs

Somatic current = 1nA, Pulse duration = 5ms

(d) A small dendritic current injection is added the threshold can be crossed and dendritic calcium spikes are elicited and eventually somatic bursting

Somatic current = 1nA, Pulse duration = 5ms, Dendritic amplitude = 1.8nA

(e) A calcium spike can also be initiated locally in the dendrite when a strong dendritic current injection is used

Somatic current = 0nA, Dendritic amplitude = 3.6nA