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After running the multicompartmental cell LEMS file:
Optimization of the dendritic calcium dynamics and somato-dendritic coupling for varying current injections into the soma and the dendrite
Interactive notebook that creates the following plots here
Note: After the parameters are reset run nrnivmodl each time inside this directory to compile the mod files to regenerate the results
(b) A small EPSP shaped dendritic current injection does not lead to spiking
(c) A somatic current pulse elicits a single somatic spike that back-propagates into the dendrite without crossing the threshold for the initiation of dendritic calcium APs
(d) A small dendritic current injection is added the threshold can be crossed and dendritic calcium spikes are elicited and eventually somatic bursting
(e) A calcium spike can also be initiated locally in the dendrite when a strong dendritic current injection is used