kca.channel.nml

<?xml version="1.0" encoding="iso-8859-1"?>
<neuroml xmlns="http://www.neuroml.org/schema/neuroml2"
         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
         xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.githubusercontent.com/NeuroML/NeuroML2/master/Schemas/NeuroML2/NeuroML_v2beta3.xsd"
         id="kca">

    <notes>WARNING: in the orginial mod file the conductance was multiplied by e-4, remember to scale your Gmax</notes>

    <ionChannel id="kca" conductance="10pS" type="ionChannelHH" species="k">

        <notes>Comment from original mod file: Calcium-dependent potassium channel,
                    Based on Pennefather (1990) -- sympathetic ganglion cells,
                    taken from Reuveni et al (1993) -- neocortical cells
                    Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu
        </notes>

	<q10ConductanceScaling q10Factor="2.3" experimentalTemp="23degC"/>

        <gate id="n" type="gateHHrates" instances="1">
            <q10Settings type="q10ExpTemp" q10Factor="2.3" experimentalTemp="23 degC"/>
            <forwardRate type="kca_n_alpha_rate"/>
            <reverseRate type="kca_n_beta_rate"/>
        </gate>

    </ionChannel>

    <ComponentType name="kca_n_alpha_rate" extends="baseVoltageConcDepRate">
        <Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
        <Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
        <Constant name="CONC_SCALE" dimension="concentration" value="1 mM"/>

        <Dynamics>
            <DerivedVariable name="V" dimension="none" value="v / VOLT_SCALE"/>
            <DerivedVariable name="ca_conc" dimension="none" value="caConc / CONC_SCALE"/>
            <DerivedVariable name="r" exposure="r" dimension="per_time" value="(0.01 * ca_conc) / TIME_SCALE"/>
        </Dynamics>

    </ComponentType>

    <ComponentType name="kca_n_beta_rate" extends="baseVoltageConcDepRate">
        <Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
        <Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
        <Constant name="CONC_SCALE" dimension="concentration" value="1 mM"/>

        <Dynamics>
            <DerivedVariable name="V" dimension="none" value="v / VOLT_SCALE"/>
            <DerivedVariable name="ca_conc" dimension="none" value="caConc / CONC_SCALE"/>
            <DerivedVariable name="r" exposure="r" dimension="per_time" value="0.02 / TIME_SCALE"/>
        </Dynamics>

    </ComponentType>


</neuroml>