Compounds sent for biological testing Nov 2018 #62

mbhebhe · 2018-11-16T02:30:28Z

Here is list of compounds that we have sent to Dundee.

Series 3:

USyd samples:
OSM-S-606 is a product of the bromination of pyrrole occurring at the 7th position.
OSM-S-137 (slightly active at 1.7 uM) was re-synthesized for sending to Kansas State Uni and UNC for kinome testing.
OSM-S-145 was synthesised but not tested and came across it in the fridge.
OSM-S-649 (carboxylic analogue of OSM-S-106) that was suggested by @drc007
SGS-UNC samples to be sent soon.
These molecules were made by Alfredo Picado from SGS-University of North Carolina. They are similar to our Series 3 compounds. We will see if they have any activity.

Series 4:

First in Series 4 5-substituted amines (made by @david1597 5-N-linked pyrazine side chains #47 ) + two molecules of 5- and 6-substituted amines (OSM-S-631 and OSM-S-634 made by @maratsydney)
OHOH compound (made by @david1597 Synthesis of "The OHOH" - a benzylic hydroxylation product #36 ) + some other compounds (including the RHS benzimidazole proposed by @MFernflower).
8-Substituted compounds that originated from tele-substitution reaction studies. The Aussies - unexpected products from substitution down under #46
Reference sample (OSM-S-369) as discussed before.

2018 November Dundee Compounds list.zip

MMV Number	SMILES	InChI	InChI Key
MMV1634420	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC(NCCC4=CC=CC=C4)=CN32	InChI=1S/C20H17F2N5O/c21-20(22)28-16-8-6-15(7-9-16)19-26-25-18-12-24-17(13-27(18)19)23-11-10-14-4-2-1-3-5-14/h1-9,12-13,20,23H,10-11H2	OPITXRFBTTVRFQ-UHFFFAOYSA-N
MMV1634421	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCCC4=CC=C(OC)C(OC)=C4)N32	InChI=1S/C22H21F2N5O3/c1-30-17-8-3-14(11-18(17)31-2)9-10-26-19-12-25-13-20-27-28-21(29(19)20)15-4-6-16(7-5-15)32-22(23)24/h3-8,11-13,22,26H,9-10H2,1-2H3	VDXJYWCEOGLVSA-UHFFFAOYSA-N
MMV1634422	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCC@@HC4=CC=CC=C4)N32	InChI=1S/C20H17F2N5O2/c21-20(22)29-15-8-6-14(7-9-15)19-26-25-18-12-23-11-17(27(18)19)24-10-16(28)13-4-2-1-3-5-13/h1-9,11-12,16,20,24,28H,10H2/t16-/m1/s1	MOIHJTIFLGFROE-MRXNPFEDSA-N
MMV1634423	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCC@HC4=CC=CC=C4)N32	InChI=1S/C20H17F2N5O2/c21-20(22)29-15-8-6-14(7-9-15)19-26-25-18-12-23-11-17(27(18)19)24-10-16(28)13-4-2-1-3-5-13/h1-9,11-12,16,20,24,28H,10H2/t16-/m0/s1	MOIHJTIFLGFROE-INIZCTEOSA-N
MMV1634424	FC(OC1=CC=C(C2=NN=C3C=NC=C(NCC4=CC=CC=C4)N32)C=C1)F	InChI=1S/C19H15F2N5O/c20-19(21)27-15-8-6-14(7-9-15)18-25-24-17-12-22-11-16(26(17)18)23-10-13-4-2-1-3-5-13/h1-9,11-12,19,23H,10H2	GWROJQFCRZTYNJ-UHFFFAOYSA-N
MMV1634425	COC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCCC4=CC=CC=C4)N32	InChI=1S/C20H19N5O/c1-26-17-9-7-16(8-10-17)20-24-23-19-14-21-13-18(25(19)20)22-12-11-15-5-3-2-4-6-15/h2-10,13-14,22H,11-12H2,1H3	BQLWJIPILDPOQZ-UHFFFAOYSA-N
MMV1634426	NC(C=C1)=CC=C1C(CO)COC2=CN=CC(N23)=NN=C3C4=CC=C(OC(F)F)C=C4	InChI=1S/C21H19F2N5O3/c22-21(23)31-17-7-3-14(4-8-17)20-27-26-18-9-25-10-19(28(18)20)30-12-15(11-29)13-1-5-16(24)6-2-13/h1-10,15,21,29H,11-12,24H2	DWSRIPSLMMOTPD-UHFFFAOYSA-N
MMV1634427	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(CO)C4=CC=C(NC)C=C4)N32	InChI=1S/C22H21F2N5O3/c1-25-17-6-2-14(3-7-17)16(12-30)13-31-20-11-26-10-19-27-28-21(29(19)20)15-4-8-18(9-5-15)32-22(23)24/h2-11,16,22,25,30H,12-13H2,1H3	YOPBTMOYZOBXTE-UHFFFAOYSA-N
MMV1634428	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CS4)N32	InChI=1S/C18H14F2N4O2S/c19-18(20)26-13-5-3-12(4-6-13)17-23-22-15-10-21-11-16(24(15)17)25-8-7-14-2-1-9-27-14/h1-6,9-11,18H,7-8H2	RMZMYNQAPRIYLW-UHFFFAOYSA-N
MMV1634429	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(C)C4=CC=CC=C4)N32	InChI=1S/C21H18F2N4O2/c1-14(15-5-3-2-4-6-15)13-28-19-12-24-11-18-25-26-20(27(18)19)16-7-9-17(10-8-16)29-21(22)23/h2-12,14,21H,13H2,1H3	YELIMUUXHYJNPF-UHFFFAOYSA-N
MMV1634430	FC(C=C1)=C(F)C=C1CCOC2=CN=CC3=NN=C(OCC4=CN=CC=C4)N32	InChI=1S/C19H15F2N5O2/c20-15-4-3-13(8-16(15)21)5-7-27-18-11-23-10-17-24-25-19(26(17)18)28-12-14-2-1-6-22-9-14/h1-4,6,8-11H,5,7,12H2	KXBYYTPVSDHELS-UHFFFAOYSA-N
MMV1634431	FC1=CC(CCOC2=CN=CC3=NN=C(C4=CC5=C(C=C4)N=CN5)N32)=CC=C1F	InChI=1S/C20H14F2N6O/c21-14-3-1-12(7-15(14)22)5-6-29-19-10-23-9-18-26-27-20(28(18)19)13-2-4-16-17(8-13)25-11-24-16/h1-4,7-11H,5-6H2,(H,24,25)	OKICKLNNAMYKHW-UHFFFAOYSA-N
MMV1634432	COC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32	InChI=1S/C20H18N4O2/c1-25-17-9-7-16(8-10-17)20-23-22-18-13-21-14-19(24(18)20)26-12-11-15-5-3-2-4-6-15/h2-10,13-14H,11-12H2,1H3	FOEYJDQRLPZFOG-UHFFFAOYSA-N
MMV1634433	O=[N+](C(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32)[O-]	InChI=1S/C19H15N5O3/c25-24(26)16-8-6-15(7-9-16)19-22-21-17-12-20-13-18(23(17)19)27-11-10-14-4-2-1-3-5-14/h1-9,12-13H,10-11H2	XKYBKXJISXRHEZ-UHFFFAOYSA-N
MMV1634434	COC(C=C1)=CC=C1C2=NN=C3C=NC=C(SCCC4=CC=CC=C4)N32	InChI=1S/C20H18N4OS/c1-25-17-9-7-16(8-10-17)20-23-22-18-13-21-14-19(24(18)20)26-12-11-15-5-3-2-4-6-15/h2-10,13-14H,11-12H2,1H3	XKLPATLXLSUHOI-UHFFFAOYSA-N
MMV1634435	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(CO)(CO)C4=CC=CC=C4)N32	InChI=1S/C22H20F2N4O4/c23-21(24)32-17-8-6-15(7-9-17)20-27-26-18-10-25-11-19(28(18)20)31-14-22(12-29,13-30)16-4-2-1-3-5-16/h1-11,21,29-30H,12-14H2	JCCXTGDCGIGQKA-UHFFFAOYSA-N
MMV1634436	C1(OCCC2=CC=CC=C2)=NC=CN3C1=NN=C3C4=CC=CC=C4	InChI=1S/C19H16N4O/c1-3-7-15(8-4-1)11-14-24-19-18-22-21-17(23(18)13-12-20-19)16-9-5-2-6-10-16/h1-10,12-13H,11,14H2	BKUOBYRSGGKOSW-UHFFFAOYSA-N
MMV1634437	COC(C=C1)=CC=C1C2=NN=C3C(OCCC4=CC=CC=C4)=NC=CN32	InChI=1S/C20H18N4O2/c1-25-17-9-7-16(8-10-17)18-22-23-19-20(21-12-13-24(18)19)26-14-11-15-5-3-2-4-6-15/h2-10,12-13H,11,14H2,1H3	KNDAUWHMGBUKCB-UHFFFAOYSA-N
MMV1634438	O=[N+](C(C=C1)=CC=C1C2=NN=C3C(OCCC4=CC=CC=C4)=NC=CN32)[O-]	InChI=1S/C19H15N5O3/c25-24(26)16-8-6-15(7-9-16)17-21-22-18-19(20-11-12-23(17)18)27-13-10-14-4-2-1-3-5-14/h1-9,11-12H,10,13H2	QMCCJGVEGJOFQH-UHFFFAOYSA-N
MMV1634439	COC(C=C1)=CC=C1C2=NN=C3C(SCCC4=CC=CC=C4)=NC=CN32	InChI=1S/C20H18N4OS/c1-25-17-9-7-16(8-10-17)18-22-23-19-20(21-12-13-24(18)19)26-14-11-15-5-3-2-4-6-15/h2-10,12-13H,11,14H2,1H3	GEUZYLOQEWPPTC-UHFFFAOYSA-N
MMV1634440	C1(SCCC2=CC=CC=C2)=NC=CN3C1=NN=C3C4=CC=CC=C4	InChI=1S/C19H16N4S/c1-3-7-15(8-4-1)11-14-24-19-18-22-21-17(23(18)13-12-20-19)16-9-5-2-6-10-16/h1-10,12-13H,11,14H2	PXOUQPVRLQGOLD-UHFFFAOYSA-N
MMV1634441	O=[N+](C(C=C1)=CC=C1C2=NN=C3C(SCCC4=CC=CC=C4)=NC=CN32)[O-]	InChI=1S/C19H15N5O2S/c25-24(26)16-8-6-15(7-9-16)17-21-22-18-19(20-11-12-23(17)18)27-13-10-14-4-2-1-3-5-14/h1-9,11-12H,10,13H2	NHMKPHMAQGUBEJ-UHFFFAOYSA-N
MMV1634442	C1(NCCC2=CC=CC=C2)=NC=CN3C1=NN=C3C4=CC=CC=C4	InChI=1S/C19H17N5/c1-3-7-15(8-4-1)11-12-20-17-19-23-22-18(24(19)14-13-21-17)16-9-5-2-6-10-16/h1-10,13-14H,11-12H2,(H,20,21)	UVSSRDWLOVROPH-UHFFFAOYSA-N
MMV1634443	COC(C=C1)=CC=C1C2=NN=C3C(NCCC4=CC=CC=C4)=NC=CN32	InChI=1S/C20H19N5O/c1-26-17-9-7-16(8-10-17)19-23-24-20-18(22-13-14-25(19)20)21-12-11-15-5-3-2-4-6-15/h2-10,13-14H,11-12H2,1H3,(H,21,22)	ZZFSYDDMUBYAFS-UHFFFAOYSA-N
MMV1634444	O=[N+](C(C=C1)=CC=C1C2=NN=C3C(NCCC4=CC=CC=C4)=NC=CN32)[O-]	InChI=1S/C19H16N6O2/c26-25(27)16-8-6-15(7-9-16)18-22-23-19-17(21-12-13-24(18)19)20-11-10-14-4-2-1-3-5-14/h1-9,12-13H,10-11H2,(H,20,21)	HFBSNRIFQOQABE-UHFFFAOYSA-N
MMV1581298	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(CO)(O)C4=CC=C(F)C(F)=C4)N32	InChI=1S/C21H16F4N4O4/c22-15-6-3-13(7-16(15)23)21(31,10-30)11-32-18-9-26-8-17-27-28-19(29(17)18)12-1-4-14(5-2-12)33-20(24)25/h1-9,20,30-31H,10-11H2	GXKONCOXFIUYEL-UHFFFAOYSA-N
MMV1581295	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(CO)(O)C4=CC=CC=C4)N32	InChI=1S/C21H18F2N4O4/c22-20(23)31-16-8-6-14(7-9-16)19-26-25-17-10-24-11-18(27(17)19)30-13-21(29,12-28)15-4-2-1-3-5-15/h1-11,20,28-29H,12-13H2	LVBNVRWXODMMAV-UHFFFAOYSA-N
MMV689970	C12=NN=C(C3=CC=CC=C3)N1C(OCCC4=CC=CC=C4)=CN=C2	InChI=1S/C19H16N4O/c1-3-7-15(8-4-1)11-12-24-18-14-20-13-17-21-22-19(23(17)18)16-9-5-2-6-10-16/h1-10,13-14H,11-12H2	YRTHPBSIEMFKFB-UHFFFAOYSA-N
MMV1634445	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(COC4=CN=CC5=NN=C(C6=CC=C(OC(F)F)C=C6)N54)(CO)C7=CC=CC=C7)N32	InChI=1S/C34H26F4N8O5/c35-32(36)50-24-10-6-21(7-11-24)30-43-41-26-14-39-16-28(45(26)30)48-19-34(18-47,23-4-2-1-3-5-23)20-49-29-17-40-15-27-42-44-31(46(27)29)22-8-12-25(13-9-22)51-33(37)38/h1-17,32-33,47H,18-20H2	SBKLVTZSIUTYAA-UHFFFAOYSA-N
MMV1634446	NC1=C2C(C(C3=CC=CC(S(=O)(N)=O)=C3)=CN2)=NC=N1	InChI=1S/C12H11N5O2S/c13-12-11-10(16-6-17-12)9(5-15-11)7-2-1-3-8(4-7)20(14,18)19/h1-6,15H,(H2,13,16,17)(H2,14,18,19)	AZDIWLYPDODQNA-UHFFFAOYSA-N
MMV1634447	FC(C=C1)=CC=C1CN(CC2)CCN2C3=C4C(C=C(C5=CC=CC(S(N)(=O)=O)=C5)S4)=NC=N3	InChI=1S/C23H22FN5O2S2/c24-18-6-4-16(5-7-18)14-28-8-10-29(11-9-28)23-22-20(26-15-27-23)13-21(32-22)17-2-1-3-19(12-17)33(25,30)31/h1-7,12-13,15H,8-11,14H2,(H2,25,30,31)	OWXZZWFFXSEZNL-UHFFFAOYSA-N
MMV1634448	NS(C1=CC=CC(C2=CC3=NC=NC(N(C)C)=C3S2)=C1)(=O)=O	InChI=1S/C14H14N4O2S2/c1-18(2)14-13-11(16-8-17-14)7-12(21-13)9-4-3-5-10(6-9)22(15,19)20/h3-8H,1-2H3,(H2,15,19,20)	CGTVWFYTOADSRO-UHFFFAOYSA-N
MMV1634449	NC1=C2C(C=C(C3=CC=CC(C(O)=O)=C3)S2)=NC=N1	InChI=1S/C13H9N3O2S/c14-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)13(17)18/h1-6H,(H,17,18)(H2,14,15,16)	JYCLMKQWHKSRJT-UHFFFAOYSA-N
MMV897698	FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32	InChI=1S/C20H16F2N4O2/c21-20(22)28-16-8-6-15(7-9-16)19-25-24-17-12-23-13-18(26(17)19)27-11-10-14-4-2-1-3-5-14/h1-9,12-13,20H,10-11H2	AVBCIJLYABLIRW-UHFFFAOYSA-N
MMV1634450	O=C(CSC1=C2C(C=C(C3=CC=CC(OC)=C3)S2)=NC=N1)O	InChI=1S/C15H12N2O3S2/c1-20-10-4-2-3-9(5-10)12-6-11-14(22-12)15(17-8-16-11)21-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	DYCCEQUNLMNCFJ-UHFFFAOYSA-N
MMV1634451	CC(C(N=C1)=CC=C1C2=CC3=NC=NC(SCC(O)=O)=C3S2)=O	InChI=1S/C15H11N3O3S2/c1-8(19)10-3-2-9(5-16-10)12-4-11-14(23-12)15(18-7-17-11)22-6-13(20)21/h2-5,7H,6H2,1H3,(H,20,21)	LGDNGRNEECNYDP-UHFFFAOYSA-N
MMV1634452	O=C(CSC1=C2C(SC(C3=CC=CC(SC)=C3)=C2)=NC=N1)O	InChI=1S/C15H12N2O2S3/c1-20-10-4-2-3-9(5-10)12-6-11-14(21-7-13(18)19)16-8-17-15(11)22-12/h2-6,8H,7H2,1H3,(H,18,19)	MNWOYBNZZSNGOO-UHFFFAOYSA-N
MMV1634453	O=C(CSC1=C2C(C=C(C3=CC=CC(OC(F)(F)F)=C3)S2)=NC=N1)O	InChI=1S/C15H9F3N2O3S2/c16-15(17,18)23-9-3-1-2-8(4-9)11-5-10-13(25-11)14(20-7-19-10)24-6-12(21)22/h1-5,7H,6H2,(H,21,22)	LVPPRPZWXKYNRR-UHFFFAOYSA-N
MMV1634454	O=C(C)NC1=CC(C2=CC3=NC=NC(SCC(O)=O)=C3S2)=CC=C1	InChI=1S/C16H13N3O3S2/c1-9(20)19-11-4-2-3-10(5-11)13-6-12-15(24-13)16(18-8-17-12)23-7-14(21)22/h2-6,8H,7H2,1H3,(H,19,20)(H,21,22)	QITKDVLQZKEZLA-UHFFFAOYSA-N
MMV1634455	O=C(CSC1=C2C(C=C(C3=CC=CS3)S2)=NC=N1)O	InChI=1S/C12H8N2O2S3/c15-10(16)5-18-12-11-7(13-6-14-12)4-9(19-11)8-2-1-3-17-8/h1-4,6H,5H2,(H,15,16)	AWGWMRKFZPUBMU-UHFFFAOYSA-N
MMV1634456	O=C(CSC1=C2C(C=C(C3=CC=CC(N4CCOCC4)=C3)S2)=NC=N1)O	InChI=1S/C18H17N3O3S2/c22-16(23)10-25-18-17-14(19-11-20-18)9-15(26-17)12-2-1-3-13(8-12)21-4-6-24-7-5-21/h1-3,8-9,11H,4-7,10H2,(H,22,23)	YNGXIFAWCXNJLT-UHFFFAOYSA-N
MMV1634457	CS(C1=CC(C2=CC3=NC=NC(SCC(O)=O)=C3S2)=CC=C1)(=O)=O	InChI=1S/C15H12N2O4S3/c1-24(20,21)10-4-2-3-9(5-10)12-6-11-14(23-12)15(17-8-16-11)22-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	BTGDYEPQMXMGFI-UHFFFAOYSA-N

mattodd · 2018-11-19T12:41:26Z

Great work from everyone @mbhebhe @maratsydney @david1597

@mbhebhe , it looks like there's an issue with a few of those SMILES above. Any obvious reason? Can you please correct? Great to see that these compounds are already in the Master List, including the UNC donated ones.

Let's keep this issue open until we obtain the data. When that happens, post the data to ELN and link to it from here, post a graphical summary on this page below, and then link from here to the wiki, to the page "data not yet included in the wiki" so that we know the data need to be folded in.

Super exciting to have all these compounds sent in. Amongst many other things, it's essential we see how the OHOH compounds do. If potent, they have the potential to become series frontrunners and we'd need to have them examined for solubility and clearance.

mbhebhe · 2018-11-21T00:19:43Z

@mattodd with those few SMILES, they have these symbols next to each other "[] ()". These symbols are for hyperlinking. So GH read it as a hyperlink.
All fixed now.

If there is an easier way around this please, someone let me know

mattodd · 2018-11-21T09:41:08Z

OK, nice one @mbhebhe. I wonder if quoting text works better, so that the blue hyperlink doesn't appear? @cdsouthan is there a way of testing whether these SMILES are being picked up correctly despite the inclusion of that hyperlink? Either way, the solution to this little nugget needs to be installed on the TechOps wiki before we close this issue. @mbhebhe can you please be sure to take care of that?

edwintse · 2018-11-21T11:08:13Z

I've found a fix. You need to add a backslash between [] and (). This removes the hyperlink and gives the correct smiles.

For example, [C@H] (O) (space added between) will be converted to this
MMV1634423 | FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCC@HC4=CC=CC=C4)N32
Adding \ between the brackets gives this instead
MMV1634423 | FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NC[C@H](O)C4=CC=CC=C4)N32

This should make the correct SMILES searchable but can someone confirm? @mattodd I can add it to the TechOps wiki but I'll need edit access to it.

cdsouthan · 2018-11-21T11:29:32Z

For searching, you can check that SMILES string renders correctly in the PubChem structure search box https://pubchem.ncbi.nlm.nih.gov/search/search.cgi# . You will find the SMILES option under the "Identity/Similarity" box. Click on "Preview" and you see the image. For newer structures, you may as well do the "Search" at the same time.

My guess is you can do the same in OpenBable, Chemicalize.org, Marvin, ChemDraw, and even good ole' SciFinder

You should be able to do a bulk check via OpenBable or https://pubchem.ncbi.nlm.nih.gov/idexchange/idexchange.cgi but need to watch out you could still get the "wrong" rendering without an error flag

MFernflower · 2018-11-21T13:34:24Z

@edwintse you can simply insert a ` at the start and end of each smiles string @mattodd

CCCC(=O)C1=C(C(=C(C=C1O)OC)CC2=C(C(C(=C(C2=O)C(=O)CCC)O)(C)C)O)O

edwintse · 2018-11-21T13:37:09Z

But that doesn't work with a string that contains [] followed by ()
FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NC[C@H](O)C4=CC=CC=C4)N32

MFernflower · 2018-11-21T13:43:17Z

@edwintse the symbol used is the grave not an apostrophe

edwintse · 2018-11-21T13:44:23Z

Ah, right you are. Either way both work.

mattodd · 2018-11-21T22:56:34Z

@cdsouthan my concern was with what a search engine actually sees. If it sees the text that we see on the page, then the rendering tricks above will work. If it actually sees the underlying structure of the web page (think the binary representation of the Matrix, vs. the Woman in the Red Dress, if you will) then is there a danger that the string will be perceived with hyperlinks, graves, double brackets? And therefore be perceived wrongly? The answer to this question may be simplest to derive through experimental test. Unless the answer is obvious.

drc007 · 2018-11-22T06:53:18Z

Why not just enclose the SMILES in a <pre> tag as shown below? https://www.w3schools.com/tags/tag_pre.asp

FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(NC[C@H](O)C4=CC=CC=C4)N32

drc007 · 2018-11-22T06:55:36Z

MFernflower · 2018-12-12T22:33:04Z

@mattodd @mbhebhe When you get the chance can you push the results to this GHI????

mbhebhe · 2018-12-13T00:50:54Z

@MFernflower we have the potency results for SGS compounds. I created a new issue for the results #65. I will close this one once we have the potency results for the USyd compounds

MFernflower · 2018-12-13T19:21:33Z

#65 results are in!!

mbhebhe added FYI Biological Data labels Nov 16, 2018

mbhebhe mentioned this issue Nov 16, 2018

Compounds for biological testing Nov 2018 (including SGS-UNC compounds) OpenSourceMalaria/Series3#11

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edwintse mentioned this issue Nov 16, 2018

Compounds for hERG Evaluation Round 2 #63

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This was referenced Nov 17, 2018

Compounds for biological testing Nov 2018 #61

Closed

Reference compound for potency tests OpenSourceMalaria/OSM_To_Do_List#572

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mbhebhe mentioned this issue Dec 13, 2018

November 2018 Potency results #65

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MFernflower closed this as completed Dec 13, 2018

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Compounds sent for biological testing Nov 2018 #62

Compounds sent for biological testing Nov 2018 #62

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Compounds sent for biological testing Nov 2018 #62

Compounds sent for biological testing Nov 2018 #62

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