diff --git a/.github/workflows/ci-tests.yml b/.github/workflows/ci-tests.yml
new file mode 100644
index 0000000..92231fe
--- /dev/null
+++ b/.github/workflows/ci-tests.yml
@@ -0,0 +1,84 @@
+name: Build and test
+
+on:
+    # Only on pushes to master or one of the release branches we build on push
+    push:
+        branches:
+            - master
+            - "[0-9].[0-9]+-branch"
+        tags:
+    # Build pull requests
+    pull_request:
+
+jobs:
+    test:
+        strategy:
+            matrix:
+                py:
+                    - "3.7"
+                    - "3.8"
+                    - "3.9"
+                    - "3.10"
+                    - "pypy-3.7"
+                os:
+                    - "ubuntu-latest"
+                    # - "windows-latest"
+                    - "macos-latest"
+                architecture:
+                    - x64
+                    - x86
+                exclude:
+                    # Linux and macOS don't have x86 python
+                    - os: "ubuntu-latest"
+                      architecture: x86
+                    - os: "macos-latest"
+                      architecture: x86
+        name: "Python: ${{ matrix.py }}-${{ matrix.architecture }} on ${{ matrix.os }}"
+        runs-on: ${{ matrix.os }}
+        steps:
+            - uses: actions/checkout@v2
+            - name: Setup python
+              uses: actions/setup-python@v2
+              with:
+                  python-version: ${{ matrix.py }}
+                  architecture: ${{ matrix.architecture }}
+            - run: pip install tox
+            - name: Running tox
+              run: tox -e py
+    # coverage:
+    #     runs-on: ubuntu-latest
+    #     name: Validate coverage
+    #     steps:
+    #         - uses: actions/checkout@v2
+    #         - name: Setup python 3.10
+    #           uses: actions/setup-python@v2
+    #           with:
+    #               python-version: "3.10"
+    #               architecture: x64
+
+    #         - run: pip install tox
+    #         - run: tox -e py310,coverage
+    docs:
+        runs-on: ubuntu-latest
+        name: Build the documentation
+        steps:
+            - uses: actions/checkout@v2
+            - name: Setup python
+              uses: actions/setup-python@v2
+              with:
+                  python-version: "3.10"
+                  architecture: x64
+            - run: pip install tox
+            - run: tox -e docs
+    # lint:
+    #     runs-on: ubuntu-latest
+    #     name: Lint the package
+    #     steps:
+    #         - uses: actions/checkout@v2
+    #         - name: Setup python
+    #           uses: actions/setup-python@v2
+    #           with:
+    #               python-version: "3.10"
+    #               architecture: x64
+    #         - run: pip install tox
+    #         - run: tox -e lint
diff --git a/.gitignore b/.gitignore
index accc766..57d7cfa 100644
--- a/.gitignore
+++ b/.gitignore
@@ -7,3 +7,5 @@ htmlcov
 .eggs
 build
 dist
+env*
+tests/fake_packages/FakeApp.egg/EGG-INFO
diff --git a/.hgignore b/.hgignore
deleted file mode 100644
index 44abbb2..0000000
--- a/.hgignore
+++ /dev/null
@@ -1,13 +0,0 @@
-syntax: glob
-*.egg-info/
-*.egg/
-*.pyc
-*.class
-dist/
-build/
-docs/_build/
-.tox
-.project
-.pydevproject
-.settings
-__pycache__
diff --git a/.travis.yml b/.travis.yml
deleted file mode 100644
index 07423a8..0000000
--- a/.travis.yml
+++ /dev/null
@@ -1,25 +0,0 @@
-sudo: false
-dist: xenial
-language: python
-install:
-      - pip install tox
-script:
-      - tox
-matrix:
-    include:
-        - python: 2.7
-          env: TOXENV=py27
-        - python: 3.4
-          env: TOXENV=py34
-        - python: 3.5
-          env: TOXENV=py35
-        - python: 3.6
-          env: TOXENV=py36
-        - python: 3.7
-          env: TOXENV=py37
-        - python: pypy
-          env: TOXENV=pypy
-          dist: trusty
-        - python: pypy3
-          env: TOXENV=pypy3
-          dist: trusty
diff --git a/docs/news.rst b/docs/news.rst
index a6dbee4..b827317 100644
--- a/docs/news.rst
+++ b/docs/news.rst
@@ -1,6 +1,11 @@
 Paste Deployment News
 =====================
 
+unreleased
+----------
+
+* Drop support for Python 2, as well as 3.4, 3.5, and 3.6.
+
 2.1.1 (2020-10-12)
 ------------------
 
diff --git a/paste/deploy/compat.py b/paste/deploy/compat.py
deleted file mode 100644
index 05047db..0000000
--- a/paste/deploy/compat.py
+++ /dev/null
@@ -1,32 +0,0 @@
-# (c) 2005 Ian Bicking and contributors; written for Paste (http://pythonpaste.org)
-# Licensed under the MIT license: http://www.opensource.org/licenses/mit-license.php
-"""Python 2<->3 compatibility module"""
-import sys
-
-
-def print_(template, *args, **kwargs):
-    template = str(template)
-    if args:
-        template = template % args
-    elif kwargs:
-        template = template % kwargs
-    sys.stdout.writelines(template)
-
-if sys.version_info < (3, 0):
-    basestring = basestring
-    from ConfigParser import ConfigParser
-    from urllib import unquote
-    iteritems = lambda d: d.iteritems()
-    dictkeys = lambda d: d.keys()
-
-    def reraise(t, e, tb):
-        exec('raise t, e, tb', dict(t=t, e=e, tb=tb))
-else:
-    basestring = str
-    from configparser import ConfigParser
-    from urllib.parse import unquote
-    iteritems = lambda d: d.items()
-    dictkeys = lambda d: list(d.keys())
-
-    def reraise(t, e, tb):
-        raise e.with_traceback(tb)
diff --git a/paste/deploy/converters.py b/paste/deploy/converters.py
index c9d87de..30a3290 100644
--- a/paste/deploy/converters.py
+++ b/paste/deploy/converters.py
@@ -1,14 +1,11 @@
 # (c) 2005 Ian Bicking and contributors; written for Paste (http://pythonpaste.org)
 # Licensed under the MIT license: http://www.opensource.org/licenses/mit-license.php
-from paste.deploy.compat import basestring
-
-
 truthy = frozenset(['true', 'yes', 'on', 'y', 't', '1'])
 falsy = frozenset(['false', 'no', 'off', 'n', 'f', '0'])
 
 
 def asbool(obj):
-    if isinstance(obj, basestring):
+    if isinstance(obj, str):
         obj = obj.strip().lower()
         if obj in truthy:
             return True
@@ -27,7 +24,7 @@ def asint(obj):
 
 
 def aslist(obj, sep=None, strip=True):
-    if isinstance(obj, basestring):
+    if isinstance(obj, str):
         lst = obj.split(sep)
         if strip:
             lst = [v.strip() for v in lst]
diff --git a/paste/deploy/loadwsgi.py b/paste/deploy/loadwsgi.py
index 9f3dd0e..2c8f827 100644
--- a/paste/deploy/loadwsgi.py
+++ b/paste/deploy/loadwsgi.py
@@ -1,13 +1,13 @@
 # (c) 2005 Ian Bicking and contributors; written for Paste (http://pythonpaste.org)
 # Licensed under the MIT license: http://www.opensource.org/licenses/mit-license.php
-from __future__ import with_statement
+from configparser import ConfigParser
 import os
-import sys
+import pkg_resources
 import re
+import sys
+from urllib.parse import unquote
 
-import pkg_resources
 
-from paste.deploy.compat import ConfigParser, unquote, iteritems, dictkeys
 from paste.deploy.util import fix_call, lookup_object
 
 __all__ = ['loadapp', 'loadserver', 'loadfilter', 'appconfig']
@@ -70,7 +70,7 @@ def defaults(self):
         Mainly to support defaults using values such as %(here)s
         """
         defaults = ConfigParser.defaults(self).copy()
-        for key, val in iteritems(defaults):
+        for key, val in defaults.items():
             defaults[key] = self.get('DEFAULT', key) or val
         return defaults
 
@@ -400,7 +400,7 @@ def __init__(self, filename):
             self.parser.read_file(f)
 
     def update_defaults(self, new_defaults, overwrite=True):
-        for key, value in iteritems(new_defaults):
+        for key, value in new_defaults.items():
             if not overwrite and key in self.parser._defaults:
                 continue
             self.parser._defaults[key] = value
@@ -660,7 +660,7 @@ def find_egg_entry_point(self, object_type, name=None):
                    dist.location,
                    ', '.join(_flatten(object_type.egg_protocols)),
                    ', '.join(_flatten([
-                dictkeys(pkg_resources.get_entry_info(self.spec, prot, name) or {})
+                list((pkg_resources.get_entry_info(self.spec, prot, name) or {}).keys())
                 for prot in protocol_options] or '(no entry points)'))))
         if len(possible) > 1:
             raise LookupError(
diff --git a/paste/deploy/paster_templates.py b/paste/deploy/paster_templates.py
index 9c5f942..edfa97a 100644
--- a/paste/deploy/paster_templates.py
+++ b/paste/deploy/paster_templates.py
@@ -4,8 +4,6 @@
 
 from paste.script.templates import Template
 
-from paste.deploy.compat import print_
-
 
 class PasteDeploy(Template):
 
@@ -30,7 +28,7 @@ def post(self, command, output_dir, vars):
              '      main = %(package)s.wsgiapp:make_app\n') % vars,
             indent=False)
         if command.verbose:
-            print_('*' * 72)
-            print_('* Run "paster serve docs/devel_config.ini" to run the sample application')
-            print_('* on http://localhost:8080')
-            print_('*' * 72)
+            print('*' * 72)
+            print('* Run "paster serve docs/devel_config.ini" to run the sample application')
+            print('* on http://localhost:8080')
+            print('*' * 72)
diff --git a/paste/deploy/util.py b/paste/deploy/util.py
index b6f766a..2a56a07 100644
--- a/paste/deploy/util.py
+++ b/paste/deploy/util.py
@@ -3,8 +3,6 @@
 import inspect
 import sys
 
-from paste.deploy.compat import reraise
-
 
 def fix_type_error(exc_info, callable, varargs, kwargs):
     """
@@ -55,7 +53,7 @@ def fix_call(callable, *args, **kw):
         val = callable(*args, **kw)
     except TypeError:
         exc_info = fix_type_error(None, callable, args, kw)
-        reraise(*exc_info)
+        raise exc_info[1] from None
     return val
 
 
diff --git a/setup.py b/setup.py
index b6906f9..866112a 100644
--- a/setup.py
+++ b/setup.py
@@ -13,7 +13,7 @@
 
 setup(
     name="PasteDeploy",
-    version="2.1.1",
+    version="3.0.dev0",
     description="Load, configure, and compose WSGI applications and servers",
     long_description=readme,
     classifiers=[
@@ -21,12 +21,11 @@
         "Intended Audience :: Developers",
         "License :: OSI Approved :: MIT License",
         "Programming Language :: Python",
-        "Programming Language :: Python :: 2.7",
         "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.4",
-        "Programming Language :: Python :: 3.5",
-        "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
+        "Programming Language :: Python :: 3.8",
+        "Programming Language :: Python :: 3.9",
+        "Programming Language :: Python :: 3.10",
         "Programming Language :: Python :: Implementation :: CPython",
         "Programming Language :: Python :: Implementation :: PyPy",
         "Topic :: Internet :: WWW/HTTP",
diff --git a/tests/test_load_package.py b/tests/test_load_package.py
index b3fea55..6ba1ad4 100644
--- a/tests/test_load_package.py
+++ b/tests/test_load_package.py
@@ -1,12 +1,9 @@
 from pprint import pprint
-import sys
-
 import pkg_resources
-
-from paste.deploy.compat import print_
+import sys
 
 
 def test_load_package():
-    print_('Path:')
+    print('Path:')
     pprint(sys.path)
-    print_(pkg_resources.require('FakeApp'))
+    print(pkg_resources.require('FakeApp'))
diff --git a/tox.ini b/tox.ini
index 7819491..4046d48 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,6 @@
 [tox]
-envlist = py27, py34, py35, py36, py37, pypy, pypy3,
+envlist =
+    py37,py38,py39,py310,pypy3,
     docs
 
 [testenv]
@@ -12,8 +13,6 @@ commands =
     py.test --cov=paste/deploy --cov-report=xml --cov-report=html --cov-report=term-missing {posargs}
 
 [testenv:docs]
-# pin to 3.5 to match what RTD uses
-basepython = python3.5
 whitelist_externals = make
 commands =
     make -C docs html epub BUILDDIR={envdir} "SPHINXOPTS=-W -E"