diff --git a/packages/base/src/Device.js b/packages/base/src/Device.js
index 93cd107e3728..39eb86201466 100644
--- a/packages/base/src/Device.js
+++ b/packages/base/src/Device.js
@@ -75,6 +75,7 @@ const detectTablet = () => {
 const supportsTouch = () => touch;
 const isIE = () => ie;
 const isSafari = () => safari;
+const isChrome = () => chrome;
 
 const isTablet = () => {
 	detectTablet();
@@ -94,6 +95,7 @@ export {
 	supportsTouch,
 	isIE,
 	isSafari,
+	isChrome,
 	isPhone,
 	isTablet,
 	isDesktop,
diff --git a/packages/main/src/Popup.hbs b/packages/main/src/Popup.hbs
index 9f8d21d79c77..65eba251445f 100644
--- a/packages/main/src/Popup.hbs
+++ b/packages/main/src/Popup.hbs
@@ -8,6 +8,8 @@
 	dir="{{effectiveDir}}"
 	@keydown={{_onkeydown}}
 	@focusout={{_onfocusout}}
+	@mouseup={{_onmouseup}}
+	@mousedown={{_onmousedown}}
 >
 
 	<span class="first-fe" data-ui5-focus-trap tabindex="0" @focusin={{forwardToLast}}></span>
diff --git a/packages/main/src/Popup.js b/packages/main/src/Popup.js
index 689265dddefc..daf2b50c4064 100644
--- a/packages/main/src/Popup.js
+++ b/packages/main/src/Popup.js
@@ -1,6 +1,7 @@
 import { renderFinished } from "@ui5/webcomponents-base/dist/Render.js";
 import litRender from "@ui5/webcomponents-base/dist/renderer/LitRenderer.js";
 import UI5Element from "@ui5/webcomponents-base/dist/UI5Element.js";
+import { isChrome } from "@ui5/webcomponents-base/dist/Device.js";
 import { getFirstFocusableElement, getLastFocusableElement } from "@ui5/webcomponents-base/dist/util/FocusableElements.js";
 import createStyleInHead from "@ui5/webcomponents-base/dist/util/createStyleInHead.js";
 import { isTabPrevious } from "@ui5/webcomponents-base/dist/Keys.js";
@@ -278,10 +279,30 @@ class Popup extends UI5Element {
 	}
 
 	_onfocusout(e) {
-		// relatedTarget is the element, which will get focus. If no such element exists, focus the root
+		// relatedTarget is the element, which will get focus. If no such element exists, focus the root.
+		// This happens after the mouse is released in order to not interrupt text selection.
 		if (!e.relatedTarget) {
-			this._root.tabIndex = -1;
-			this._root.focus();
+			this._shouldFocusRoot = true;
+		}
+	}
+
+	_onmousedown(e) {
+		this._root.removeAttribute("tabindex");
+
+		if (this.shadowRoot.contains(e.target)) {
+			this._shouldFocusRoot = true;
+		} else {
+			this._shouldFocusRoot = false;
+		}
+	}
+
+	_onmouseup() {
+		this._root.tabIndex = -1;
+		if (this._shouldFocusRoot) {
+			if (isChrome()) {
+				this._root.focus();
+			}
+			this._shouldFocusRoot = false;
 		}
 	}