diff --git a/packages/media-utils/src/components/media-upload/index.js b/packages/media-utils/src/components/media-upload/index.js
index 732a9bcabd79f..91de011869ad3 100644
--- a/packages/media-utils/src/components/media-upload/index.js
+++ b/packages/media-utils/src/components/media-upload/index.js
@@ -400,6 +400,8 @@ class MediaUpload extends Component {
 		if ( onClose ) {
 			onClose();
 		}
+
+		this.frame.detach();
 	}
 
 	updateCollection() {