diff --git a/docs/binspreader.md b/docs/binspreader.md index 4b743c7aa..6b23a4be7 100644 --- a/docs/binspreader.md +++ b/docs/binspreader.md @@ -3,12 +3,18 @@ BinSPreader is a tool that attempts to refine metagenome-assembled genomes (MAGs) obtained from existing tools. BinSPreader exploits the assembly graph topology and other connectivity information, such as paired-end and Hi-C reads, -to refine the existing binning, correct binning errors, propagate binning from -longer contigs to shorter contigs, and infer contigs belonging to multiple bins. +to refine the existing binning, correct binning errors, and propagate binning from +longer contigs to shorter contigs, and infer contigs belonging to multiple MAGs. +Please refer to the [BinSPreader paper](https://www.sciencedirect.com/science/article/pii/S2589004222010422) +for more details. In addition to increasing the completeness of the bins, refinement +also enriches bins with contigs containing important conservative genes using the +short assembly graph edges which are typically underrepresented in state-of-the-art +contig binning methods. The tool requires initial binning to refine, as well as an assembly graph as a source of information for refining. Optionally, BinSPreader can be provided with -multiple Hi-C and/or paired-end libraries. +multiple Hi-C and/or paired-end libraries. The [BinSPreader protocol](https://star-protocols.cell.com/protocols/2802) contains more detailed +instructions on installing and running BinSPreader. ## Command line options