diff --git a/superset/config.py b/superset/config.py
index 8d00e519a8ed3..43567c01c5ea2 100644
--- a/superset/config.py
+++ b/superset/config.py
@@ -1101,7 +1101,9 @@ def EMAIL_HEADER_MUTATOR(  # pylint: disable=invalid-name,unused-argument
 
 # Define a list of usernames to be excluded from all dropdown lists of users
 # Owners, filters for created_by, etc.
-EXCLUDE_USER_USERNAMES: List[str] = []
+# The users can also be excluded by overriding the get_exclude_users_from_lists method
+# in security manager
+EXCLUDE_USERS_FROM_LISTS: Optional[List[str]] = None
 
 
 # This auth provider is used by background (offline) tasks that need to access
diff --git a/superset/security/manager.py b/superset/security/manager.py
index 260dbb49ee7d4..eaf827ef90463 100644
--- a/superset/security/manager.py
+++ b/superset/security/manager.py
@@ -1702,6 +1702,22 @@ def on_permission_view_after_delete(
         :param target: The mapped instance being persisted
         """
 
+    @staticmethod
+    def get_exclude_users_from_lists() -> List[str]:
+        """
+        Override to dynamically identify a list of usernames to exclude from
+        all UI dropdown lists, owners, created_by filters etc...
+
+        It will exclude all users from the all endpoints of the form
+        ``/api/v1/<modelview>/related/<column>``
+
+        Optionally you can also exclude them using the `EXCLUDE_USERS_FROM_LISTS`
+        config setting.
+
+        :return: A list of usernames
+        """
+        return []
+
     def raise_for_access(
         # pylint: disable=too-many-arguments,too-many-locals
         self,
diff --git a/superset/views/filters.py b/superset/views/filters.py
index 090234421ae63..7f3dfd29306e7 100644
--- a/superset/views/filters.py
+++ b/superset/views/filters.py
@@ -57,7 +57,7 @@ def apply(self, query: Query, value: Optional[Any]) -> Query:
 class BaseFilterRelatedUsers(BaseFilter):  # pylint: disable=too-few-public-methods
 
     """
-    Filter to apply on related users. Will exclude users in EXCLUDE_USER_USERNAMES
+    Filter to apply on related users. Will exclude users in EXCLUDE_USERS_FROM_LISTS
 
     Use in the api by adding something like:
     ```
@@ -73,9 +73,10 @@ class BaseFilterRelatedUsers(BaseFilter):  # pylint: disable=too-few-public-meth
 
     def apply(self, query: Query, value: Optional[Any]) -> Query:
         user_model = security_manager.user_model
-        query_ = query.filter(
-            and_(
-                user_model.username.not_in(current_app.config["EXCLUDE_USER_USERNAMES"])
-            )
+        exclude_users = (
+            security_manager.get_exclude_users_from_lists()
+            if current_app.config["EXCLUDE_USERS_FROM_LISTS"] is None
+            else current_app.config["EXCLUDE_USERS_FROM_LISTS"]
         )
+        query_ = query.filter(and_(user_model.username.not_in(exclude_users)))
         return query_
diff --git a/tests/integration_tests/base_api_tests.py b/tests/integration_tests/base_api_tests.py
index ce99a778549de..66544f1447e05 100644
--- a/tests/integration_tests/base_api_tests.py
+++ b/tests/integration_tests/base_api_tests.py
@@ -16,6 +16,8 @@
 # under the License.
 # isort:skip_file
 import json
+from unittest.mock import patch
+
 from tests.integration_tests.fixtures.world_bank_dashboard import (
     load_world_bank_dashboard_with_slices,
     load_world_bank_data,
@@ -32,6 +34,7 @@
 from superset.views.base_api import BaseSupersetModelRestApi, requires_json
 
 from .base_tests import SupersetTestCase
+from .conftest import with_config
 
 
 class Model1Api(BaseSupersetModelRestApi):
@@ -288,13 +291,13 @@ def test_get_filter_related_owners(self):
         # TODO Check me
         assert expected_results == sorted_results
 
+    @with_config({"EXCLUDE_USERS_FROM_LISTS": ["gamma"]})
     def test_get_base_filter_related_owners(self):
         """
         API: Test get base filter related owners
         """
         self.login(username="admin")
         uri = f"api/v1/{self.resource_name}/related/owners"
-        self.app.config["EXCLUDE_USER_USERNAMES"] = ["gamma"]
         gamma_user = (
             db.session.query(security_manager.user_model)
             .filter(security_manager.user_model.username == "gamma")
@@ -309,8 +312,33 @@ def test_get_base_filter_related_owners(self):
         assert response["count"] == len(users) - 1
         response_users = [result["text"] for result in response["result"]]
         assert "gamma user" not in response_users
-        # revert the config change
-        self.app.config["EXCLUDE_USER_USERNAMES"] = []
+
+    @patch(
+        "superset.security.SupersetSecurityManager.get_exclude_users_from_lists",
+        return_value=["gamma"],
+    )
+    def test_get_base_filter_related_owners_on_sm(
+        self, mock_get_exclude_users_from_list
+    ):
+        """
+        API: Test get base filter related owners using security manager
+        """
+        self.login(username="admin")
+        uri = f"api/v1/{self.resource_name}/related/owners"
+        gamma_user = (
+            db.session.query(security_manager.user_model)
+            .filter(security_manager.user_model.username == "gamma")
+            .one_or_none()
+        )
+        assert gamma_user is not None
+        users = db.session.query(security_manager.user_model).all()
+
+        rv = self.client.get(uri)
+        assert rv.status_code == 200
+        response = json.loads(rv.data.decode("utf-8"))
+        assert response["count"] == len(users) - 1
+        response_users = [result["text"] for result in response["result"]]
+        assert "gamma user" not in response_users
 
     def test_get_ids_related_owners(self):
         """
diff --git a/tests/integration_tests/conftest.py b/tests/integration_tests/conftest.py
index c117422adc1bc..463f93b833681 100644
--- a/tests/integration_tests/conftest.py
+++ b/tests/integration_tests/conftest.py
@@ -19,7 +19,7 @@
 import contextlib
 import functools
 import os
-from typing import Any, Callable, Optional, TYPE_CHECKING
+from typing import Any, Callable, Dict, Optional, TYPE_CHECKING
 from unittest.mock import patch
 
 import pytest
@@ -255,6 +255,38 @@ def wrapper(*args, **kwargs):
     return decorate
 
 
+def with_config(override_config: Dict[str, Any]):
+    """
+    Use this decorator to mock specific config keys.
+
+    Usage:
+
+        class TestYourFeature(SupersetTestCase):
+
+            @with_config({"SOME_CONFIG": True})
+            def test_your_config(self):
+                self.assertEqual(curren_app.config["SOME_CONFIG"), True)
+
+    """
+
+    def decorate(test_fn):
+        config_backup = {}
+
+        def wrapper(*args, **kwargs):
+            from flask import current_app
+
+            for key, value in override_config.items():
+                config_backup[key] = current_app.config[key]
+                current_app.config[key] = value
+            test_fn(*args, **kwargs)
+            for key, value in config_backup.items():
+                current_app.config[key] = value
+
+        return functools.update_wrapper(wrapper, test_fn)
+
+    return decorate
+
+
 @pytest.fixture
 def virtual_dataset():
     from superset.connectors.sqla.models import SqlaTable, SqlMetric, TableColumn