diff --git a/superset-frontend/packages/superset-ui-core/src/connection/callApi/callApi.ts b/superset-frontend/packages/superset-ui-core/src/connection/callApi/callApi.ts
index f50b24127e7a6..7c3fe21fdb8a4 100644
--- a/superset-frontend/packages/superset-ui-core/src/connection/callApi/callApi.ts
+++ b/superset-frontend/packages/superset-ui-core/src/connection/callApi/callApi.ts
@@ -96,25 +96,34 @@ export default async function callApi({
     CACHE_AVAILABLE &&
     (window.location && window.location.protocol) === 'https:'
   ) {
-    const supersetCache = await caches.open(CACHE_KEY);
-    const cachedResponse = await supersetCache.match(url);
-    if (cachedResponse) {
-      // if we have a cached response, send its ETag in the
-      // `If-None-Match` header in a conditional request
-      const etag = cachedResponse.headers.get('Etag') as string;
-      request.headers = { ...request.headers, 'If-None-Match': etag };
+    let supersetCache: Cache | null = null;
+    try {
+      supersetCache = await caches.open(CACHE_KEY);
+      const cachedResponse = await supersetCache.match(url);
+      if (cachedResponse) {
+        // if we have a cached response, send its ETag in the
+        // `If-None-Match` header in a conditional request
+        const etag = cachedResponse.headers.get('Etag') as string;
+        request.headers = { ...request.headers, 'If-None-Match': etag };
+      }
+    } catch {
+      // If superset is in an iframe and third-party cookies are disabled, caches.open throws
     }
 
     const response = await fetchWithRetry(url, request);
 
-    if (response.status === HTTP_STATUS_NOT_MODIFIED) {
+    if (supersetCache && response.status === HTTP_STATUS_NOT_MODIFIED) {
       const cachedFullResponse = await supersetCache.match(url);
       if (cachedFullResponse) {
         return cachedFullResponse.clone();
       }
       throw new Error('Received 304 but no content is cached!');
     }
-    if (response.status === HTTP_STATUS_OK && response.headers.get('Etag')) {
+    if (
+      supersetCache &&
+      response.status === HTTP_STATUS_OK &&
+      response.headers.get('Etag')
+    ) {
       supersetCache.delete(url);
       supersetCache.put(url, response.clone());
     }
diff --git a/superset-frontend/packages/superset-ui-core/src/query/api/v1/makeApi.ts b/superset-frontend/packages/superset-ui-core/src/query/api/v1/makeApi.ts
index f286d93f4ea81..b7229cc98006b 100644
--- a/superset-frontend/packages/superset-ui-core/src/query/api/v1/makeApi.ts
+++ b/superset-frontend/packages/superset-ui-core/src/query/api/v1/makeApi.ts
@@ -68,23 +68,26 @@ export default function makeApi<
   Payload = SupersetPayload,
   Result = JsonObject,
   T extends ParseMethod = ParseMethod,
->({
-  endpoint,
-  method,
-  requestType: requestType_,
-  responseType,
-  processResponse,
-  ...requestOptions
-}: SupersetApiFactoryOptions & {
-  /**
-   * How to parse response, choose from: 'json' | 'text' | 'raw'.
-   */
-  responseType?: T;
-  /**
-   * Further process parsed response
-   */
-  processResponse?(result: ParsedResponseType<T>): Result;
-}) {
+>(
+  options: SupersetApiFactoryOptions & {
+    /**
+     * How to parse response, choose from: 'json' | 'text' | 'raw'.
+     */
+    responseType?: T;
+    /**
+     * Further process parsed response
+     */
+    processResponse?(result: ParsedResponseType<T>): Result;
+  },
+) {
+  const {
+    endpoint,
+    method,
+    requestType: requestType_,
+    responseType,
+    processResponse,
+    ...requestOptions
+  } = options;
   // use `search` payload (searchParams) when it's a GET request
   const requestType =
     requestType_ || (isPayloadless(method) ? 'search' : 'json');