diff --git a/pyupgrade/_ast_helpers.py b/pyupgrade/_ast_helpers.py
index fdd34abf..6a556c5a 100644
--- a/pyupgrade/_ast_helpers.py
+++ b/pyupgrade/_ast_helpers.py
@@ -42,3 +42,11 @@ def has_starargs(call: ast.Call) -> bool:
         any(k.arg is None for k in call.keywords) or
         any(isinstance(a, ast.Starred) for a in call.args)
     )
+
+
+def contains_await(node: ast.AST) -> bool:
+    for node_ in ast.walk(node):
+        if isinstance(node_, ast.Await):
+            return True
+    else:
+        return False
diff --git a/pyupgrade/_main.py b/pyupgrade/_main.py
index 24bfbb67..f27807a9 100644
--- a/pyupgrade/_main.py
+++ b/pyupgrade/_main.py
@@ -25,6 +25,7 @@
 
 from pyupgrade._ast_helpers import ast_parse
 from pyupgrade._ast_helpers import ast_to_offset
+from pyupgrade._ast_helpers import contains_await
 from pyupgrade._ast_helpers import has_starargs
 from pyupgrade._data import FUNCS
 from pyupgrade._data import Settings
@@ -520,14 +521,6 @@ def _format_params(call: ast.Call) -> Set[str]:
     return params
 
 
-def _contains_await(node: ast.AST) -> bool:
-    for node_ in ast.walk(node):
-        if isinstance(node_, ast.Await):
-            return True
-    else:
-        return False
-
-
 class FindPy36Plus(ast.NodeVisitor):
     def __init__(self, *, min_version: Version) -> None:
         self.fstrings: Dict[Offset, ast.Call] = {}
@@ -600,7 +593,7 @@ def visit_Call(self, node: ast.Call) -> None:
                     if not candidate:
                         i += 1
             else:
-                if self.min_version >= (3, 7) or not _contains_await(node):
+                if self.min_version >= (3, 7) or not contains_await(node):
                     self.fstrings[ast_to_offset(node)] = node
 
         self.generic_visit(node)
diff --git a/pyupgrade/_plugins/generator_expressions_pep289.py b/pyupgrade/_plugins/generator_expressions_pep289.py
index 82e66abe..f90a5913 100644
--- a/pyupgrade/_plugins/generator_expressions_pep289.py
+++ b/pyupgrade/_plugins/generator_expressions_pep289.py
@@ -8,6 +8,7 @@
 from tokenize_rt import Token
 
 from pyupgrade._ast_helpers import ast_to_offset
+from pyupgrade._ast_helpers import contains_await
 from pyupgrade._data import register
 from pyupgrade._data import State
 from pyupgrade._data import TokenFunc
@@ -55,7 +56,8 @@ def visit_Call(
             not any(
                 generator.is_async
                 for generator in node.args[0].generators
-            )
+            ) and
+            not contains_await(node.args[0])
     ):
         if len(node.args) == 1 and not node.keywords:
             yield ast_to_offset(node.args[0]), _delete_list_comp_brackets
diff --git a/tests/features/generator_expressions_pep289_test.py b/tests/features/generator_expressions_pep289_test.py
index 5d91d36c..f3877983 100644
--- a/tests/features/generator_expressions_pep289_test.py
+++ b/tests/features/generator_expressions_pep289_test.py
@@ -28,6 +28,13 @@
             '    sum([i async for i in foo()])\n',
             id='Contains async',
         ),
+        pytest.param(
+            'tuple([\n'
+            '    await self._configure_component(hass, controller_config)\n'
+            '    for controller_config in configs\n'
+            '])\n',
+            id='Contains await',
+        ),
     ),
 )
 def test_fix_generator_expressions_noop(s):