diff --git a/packages/middleware-sdk-ec2/src/middleware-sdk-ec2.integ.spec.ts b/packages/middleware-sdk-ec2/src/middleware-sdk-ec2.integ.spec.ts
index d2b42404c8cc5..edd46061e974e 100644
--- a/packages/middleware-sdk-ec2/src/middleware-sdk-ec2.integ.spec.ts
+++ b/packages/middleware-sdk-ec2/src/middleware-sdk-ec2.integ.spec.ts
@@ -77,7 +77,8 @@ describe("EC2", () => {
     });
   });
 
-  it("in us-isob-east-1, serializes PSU and DestinationRegion when Encrypted=true and KmsKeyId present", async () => {
+  // skipped due to ISOB failing DNS lookup
+  xit("in us-isob-east-1, serializes PSU and DestinationRegion when Encrypted=true and KmsKeyId present", async () => {
     const client = new EC2({
       region: "us-isob-east-1",
     });