You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Is your feature request related to a problem? Please describe.
Implement PP5 and BP6 criteria. However, it seems, that this criteria were depricated.
Describe the solution you'd like
Investigate
Make a plan
Describe alternatives you've considered
N/A
Additional context
Intervar
PP5 and BP6 by Automated Scoring
If a reputable source has already reported a variant as pathogenic but the evidence is not provided for independent evaluation, then PP5 will be applied. When a reputable source has already reported a benign variant but without detailed evidence, then BP6 will be applied. In InterVar, we used the ClinVar dataset (subject to the same data-cleaning procedure described above) to perform this analysis by default, but users can select to use HGMD or other proprietary databases for this analysis.
The text was updated successfully, but these errors were encountered:
Is your feature request related to a problem? Please describe.
Implement
PP5
andBP6
criteria. However, it seems, that this criteria were depricated.Describe the solution you'd like
Describe alternatives you've considered
N/A
Additional context
Intervar
PP5 and BP6 by Automated Scoring
If a reputable source has already reported a variant as pathogenic but the evidence is not provided for independent evaluation, then PP5 will be applied. When a reputable source has already reported a benign variant but without detailed evidence, then BP6 will be applied. In InterVar, we used the ClinVar dataset (subject to the same data-cleaning procedure described above) to perform this analysis by default, but users can select to use HGMD or other proprietary databases for this analysis.
The text was updated successfully, but these errors were encountered: