diff --git a/config.go b/config.go
index a162c47da5d..bf4f0affcac 100644
--- a/config.go
+++ b/config.go
@@ -1155,6 +1155,14 @@ func loadConfig() (*config, []string, error) {
 		return nil, nil, err
 	}
 
+	if cfg.Prune != 0 && cfg.AddrIndex {
+		err := fmt.Errorf("%s: the --prune and --addrindex options may "+
+			"not be activated at the same time", funcName)
+		fmt.Fprintln(os.Stderr, err)
+		fmt.Fprintln(os.Stderr, usageMessage)
+		return nil, nil, err
+	}
+
 	// Warn about missing config file only after all other configuration is
 	// done.  This prevents the warning on help messages and invalid
 	// options.  Note this should go directly before the return.