diff --git a/python_dependencies/backend/common/server/requirements.txt b/python_dependencies/backend/common/server/requirements.txt
index b5465d1f437b7..bdb8765d58540 100644
--- a/python_dependencies/backend/common/server/requirements.txt
+++ b/python_dependencies/backend/common/server/requirements.txt
@@ -1,7 +1,7 @@
 connexion[swagger-ui]~=2.14.2
 gunicorn[gevent]~=22.0.0
 furl~=2.1.2
-Flask-Cors~=3.0.6
+Flask-Cors~=4.0.1
 flask-server-timing~=0.1.2
 ddtrace~=2.8.5
 python-json-logger
diff --git a/python_dependencies/backend/requirements.txt b/python_dependencies/backend/requirements.txt
index ca313b3780a24..8fb227df36764 100644
--- a/python_dependencies/backend/requirements.txt
+++ b/python_dependencies/backend/requirements.txt
@@ -26,4 +26,4 @@ SQLAlchemy-Utils
 SQLAlchemy==2.*
 tenacity
 tiledb
-Werkzeug==2.2.3
+Werkzeug==3.0.6
diff --git a/python_dependencies/cellguide_pipeline/requirements.txt b/python_dependencies/cellguide_pipeline/requirements.txt
index fb1e903dfcaf0..b8c747b8f6fff 100644
--- a/python_dependencies/cellguide_pipeline/requirements.txt
+++ b/python_dependencies/cellguide_pipeline/requirements.txt
@@ -10,10 +10,10 @@ openai==0.27.7
 pandas==2.2.1
 psutil==5.9.5
 pydantic==2.6.4
-requests==2.31.0
+requests==2.32.2
 scipy==1.11.1
 tiledb
 tiledbsoma>=1.7.0
-urllib3==1.26.16
+urllib3==1.26.19
 pyarrow==12.0.0
 dask==2023.8.1
diff --git a/python_dependencies/wmg_processing/requirements.txt b/python_dependencies/wmg_processing/requirements.txt
index 90f8a1de08f2b..ef899cbfbeb00 100644
--- a/python_dependencies/wmg_processing/requirements.txt
+++ b/python_dependencies/wmg_processing/requirements.txt
@@ -12,7 +12,7 @@ openai==0.27.7
 pandas==2.2.1
 psutil==5.9.5
 pyarrow==12.0.0
-pydantic==1.10.7
+pydantic==1.10.13
 pygraphviz==1.11
 python-json-logger==2.0.7
 requests>=2.22.0