diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4df5347fc2d..020dedcef30 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@ We use *breaking :warning:* to mark changes that are not backward compatible (re
 - [#6352](https://github.com/thanos-io/thanos/pull/6352) Store: Expose store gateway query stats in series response hints.
 - [#6420](https://github.com/thanos-io/thanos/pull/6420) Index Cache: Cache expanded postings.
 - [#6441](https://github.com/thanos-io/thanos/pull/6441) Compact: Compactor will set `index_stats` in `meta.json` file with max series and chunk size information.
+- [#6466](https://github.com/thanos-io/thanos/pull/6466) Mixin (Receive): add limits alerting for configuration reload and meta-monitoring.
 
 ### Fixed
 - [#6456](https://github.com/thanos-io/thanos/pull/6456) Store: fix crash when computing set matches from regex pattern
diff --git a/examples/alerts/alerts.md b/examples/alerts/alerts.md
index 1e59873cf51..1f564610734 100644
--- a/examples/alerts/alerts.md
+++ b/examples/alerts/alerts.md
@@ -530,6 +530,24 @@ rules:
   for: 3h
   labels:
     severity: critical
+- alert: ThanosReceiveLimitsConfigReloadFailure
+  annotations:
+    description: Thanos Receive {{$labels.job}} has not been able to reload the limits configuration.
+    runbook_url: https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitsconfigreloadfailure
+    summary: Thanos Receive has not been able to reload the limits configuration.
+  expr: sum by(job) (increase(thanos_receive_limits_config_reload_err_total{job=~".*thanos-receive.*"}[5m])) > 0
+  for: 5m
+  labels:
+    severity: warning
+- alert: ThanosReceiveLimitsHighMetaMonitoringQueriesFailureRate
+  annotations:
+    description: Thanos Receive {{$labels.job}} is failing for {{$value | humanize}}% of meta monitoring queries.
+    runbook_url: https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitshighmetamonitoringqueriesfailurerate
+    summary: Thanos Receive has not been able to update the number of head series.
+  expr: (sum by(job) (increase(thanos_receive_metamonitoring_failed_queries_total{job=~".*thanos-receive.*"}[5m])) / 20) * 100 > 20
+  for: 5m
+  labels:
+    severity: warning
 ```
 
 ## Replicate
diff --git a/examples/alerts/alerts.yaml b/examples/alerts/alerts.yaml
index 7d99fdba804..55cb1404197 100644
--- a/examples/alerts/alerts.yaml
+++ b/examples/alerts/alerts.yaml
@@ -274,6 +274,24 @@ groups:
     for: 3h
     labels:
       severity: critical
+  - alert: ThanosReceiveLimitsConfigReloadFailure
+    annotations:
+      description: Thanos Receive {{$labels.job}} has not been able to reload the limits configuration.
+      runbook_url: https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitsconfigreloadfailure
+      summary: Thanos Receive has not been able to reload the limits configuration.
+    expr: sum by(job) (increase(thanos_receive_limits_config_reload_err_total{job=~".*thanos-receive.*"}[5m])) > 0
+    for: 5m
+    labels:
+      severity: warning
+  - alert: ThanosReceiveLimitsHighMetaMonitoringQueriesFailureRate
+    annotations:
+      description: Thanos Receive {{$labels.job}} is failing for {{$value | humanize}}% of meta monitoring queries.
+      runbook_url: https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitshighmetamonitoringqueriesfailurerate
+      summary: Thanos Receive has not been able to update the number of head series.
+    expr: (sum by(job) (increase(thanos_receive_metamonitoring_failed_queries_total{job=~".*thanos-receive.*"}[5m])) / 20) * 100 > 20
+    for: 5m
+    labels:
+      severity: warning
 - name: thanos-sidecar
   rules:
   - alert: ThanosSidecarBucketOperationsFailed
diff --git a/mixin/alerts/receive.libsonnet b/mixin/alerts/receive.libsonnet
index 00da01211cd..528827a2c2d 100644
--- a/mixin/alerts/receive.libsonnet
+++ b/mixin/alerts/receive.libsonnet
@@ -5,6 +5,7 @@
     httpErrorThreshold: 5,
     ingestionThreshold: 50,
     forwardErrorThreshold: 20,
+    metaMonitoringErrorThreshold: 20,
     refreshErrorThreshold: 0,
     p99LatencyThreshold: 10,
     dimensions: std.join(', ', std.objectFields(thanos.targetGroups) + ['job']),
@@ -144,6 +145,31 @@
               severity: 'critical',
             },
           },
+          {
+            alert: 'ThanosReceiveLimitsConfigReloadFailure',
+            annotations: {
+              description: 'Thanos Receive {{$labels.job}}%s has not been able to reload the limits configuration.' % location,
+              summary: 'Thanos Receive has not been able to reload the limits configuration.',
+            },
+            expr: 'sum by(%(dimensions)s) (increase(thanos_receive_limits_config_reload_err_total{%(selector)s}[5m])) > 0' % thanos.receive,
+            'for': '5m',
+            labels: {
+              severity: 'warning',
+            },
+          },
+          {
+            alert: 'ThanosReceiveLimitsHighMetaMonitoringQueriesFailureRate',
+            annotations: {
+              description: 'Thanos Receive {{$labels.job}}%s is failing for {{$value | humanize}}%% of meta monitoring queries.' % location,
+              summary: 'Thanos Receive has not been able to update the number of head series.',
+            },
+            // Values are updated every 15s, 20 times over 5 minutes.
+            expr: '(sum by(%(dimensions)s) (increase(thanos_receive_metamonitoring_failed_queries_total{%(selector)s}[5m])) / 20) * 100 > %(metaMonitoringErrorThreshold)s' % thanos.receive,
+            'for': '5m',
+            labels: {
+              severity: 'warning',
+            },
+          },
         ],
       },
     ],
diff --git a/mixin/runbook.md b/mixin/runbook.md
index 833cf1d4033..ba2131cd91e 100755
--- a/mixin/runbook.md
+++ b/mixin/runbook.md
@@ -63,6 +63,8 @@
 |ThanosReceiveHighHashringFileRefreshFailures|Thanos Receive is failing to refresh hasring file.|Thanos Receive {{$labels.job}} is failing to refresh hashring file, {{$value  humanize}} of attempts failed.|warning|[https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivehighhashringfilerefreshfailures](https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivehighhashringfilerefreshfailures)|
 |ThanosReceiveConfigReloadFailure|Thanos Receive has not been able to reload configuration.|Thanos Receive {{$labels.job}} has not been able to reload hashring configurations.|warning|[https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceiveconfigreloadfailure](https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceiveconfigreloadfailure)|
 |ThanosReceiveNoUpload|Thanos Receive has not uploaded latest data to object storage.|Thanos Receive {{$labels.instance}} has not uploaded latest data to object storage.|critical|[https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivenoupload](https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivenoupload)|
+|ThanosReceiveLimitsConfigReloadFailure|Thanos Receive has not been able to reload the limits configuration.|Thanos Receive {{$labels.job}} has not been able to reload the limits configuration.|warning|[https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitsconfigreloadfailure](https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitsconfigreloadfailure)|
+|ThanosReceiveLimitsHighMetaMonitoringQueriesFailureRate|Thanos Receive has not been able to update the number of head series.|Thanos Receive {{$labels.job}} is failing for {{$value  humanize}}% of meta monitoring queries.|warning|[https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitshighmetamonitoringqueriesfailurerate](https://github.com/thanos-io/thanos/tree/main/mixin/runbook.md#alert-name-thanosreceivelimitshighmetamonitoringqueriesfailurerate)|
 
 ## thanos-rule
 
diff --git a/pkg/rules/rules_test.go b/pkg/rules/rules_test.go
index 09142586032..b5ee5dacd26 100644
--- a/pkg/rules/rules_test.go
+++ b/pkg/rules/rules_test.go
@@ -69,7 +69,7 @@ func testRulesAgainstExamples(t *testing.T, dir string, server rulespb.RulesServ
 			Name: "thanos-receive",
 			File: filepath.Join(dir, "alerts.yaml"),
 			Rules: []*rulespb.Rule{
-				someAlert, someAlert, someAlert, someAlert, someAlert, someAlert, someAlert,
+				someAlert, someAlert, someAlert, someAlert, someAlert, someAlert, someAlert, someAlert, someAlert,
 			},
 			Interval:                60,
 			PartialResponseStrategy: storepb.PartialResponseStrategy_ABORT,