diff --git a/src/coreclr/jit/morph.cpp b/src/coreclr/jit/morph.cpp
index 8f5713774890e7..432db3b0426d2b 100644
--- a/src/coreclr/jit/morph.cpp
+++ b/src/coreclr/jit/morph.cpp
@@ -12661,8 +12661,7 @@ GenTree* Compiler::fgMorphSmpOp(GenTree* tree, MorphAddrContext* mac)
 
             // Skip optimization if non-NEG operand is constant.
             // Both op1 and op2 are not constant because it was already checked above.
-            if (opts.OptimizationEnabled() && fgGlobalMorph &&
-                (((op1->gtFlags & GTF_EXCEPT) == 0) || ((op2->gtFlags & GTF_EXCEPT) == 0)))
+            if (opts.OptimizationEnabled() && fgGlobalMorph)
             {
                 // a - -b = > a + b
                 // SUB(a, (NEG(b)) => ADD(a, b)
@@ -12687,7 +12686,7 @@ GenTree* Compiler::fgMorphSmpOp(GenTree* tree, MorphAddrContext* mac)
                 // -a - -b = > b - a
                 // SUB(NEG(a), (NEG(b)) => SUB(b, a)
 
-                if (op1->OperIs(GT_NEG) && op2->OperIs(GT_NEG))
+                if (op1->OperIs(GT_NEG) && op2->OperIs(GT_NEG) && gtCanSwapOrder(op1, op2))
                 {
                     // tree: SUB
                     // op1: NEG
@@ -12886,15 +12885,14 @@ GenTree* Compiler::fgMorphSmpOp(GenTree* tree, MorphAddrContext* mac)
                     }
                 }
 
-                if (opts.OptimizationEnabled() && fgGlobalMorph &&
-                    (((op1->gtFlags & GTF_EXCEPT) == 0) || ((op2->gtFlags & GTF_EXCEPT) == 0)))
+                if (opts.OptimizationEnabled() && fgGlobalMorph)
                 {
                     // - a + b = > b - a
                     // ADD((NEG(a), b) => SUB(b, a)
 
                     // Skip optimization if non-NEG operand is constant.
-                    if (op1->OperIs(GT_NEG) && !op2->OperIs(GT_NEG) &&
-                        !(op2->IsCnsIntOrI() && varTypeIsIntegralOrI(typ)))
+                    if (op1->OperIs(GT_NEG) && !op2->OperIs(GT_NEG) && !op2->IsIntegralConst() &&
+                        gtCanSwapOrder(op1, op2))
                     {
                         // tree: ADD
                         // op1: NEG
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.cs b/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.cs
new file mode 100644
index 00000000000000..220d40aa87750a
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.cs
@@ -0,0 +1,43 @@
+using System;
+using System.Runtime.CompilerServices;
+
+public class Runtime_55140
+{
+    private static int _value;
+
+    public static int Main()
+    {
+        _value = 100;
+        if (TestSubNegNeg() is not 1 and var subNegNeg)
+        {
+            Console.WriteLine($"TestSubNegNeg returned: {subNegNeg}. Expected: 1");
+            return 101;
+        }
+
+        _value = 100;
+        if (TestAddNeg() is not 1 and var addNeg)
+        {
+            Console.WriteLine($"TestAddNeg returned: {addNeg}. Expected: 1");
+            return 102;
+        }
+
+        return 100;
+    }
+
+    // Test that the ADD(NEG(a), b) => SUB(b, a) transform does not reorder persistent side effects.
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    private static int TestAddNeg()
+    {
+        return -Increment() + _value;
+    }
+
+    // Test that the SUB(NEG(a), NEG(b)) => SUB(b, a) transform does not reorder persistent side effects.
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    private static int TestSubNegNeg()
+    {
+        return -Increment() - -_value;
+    }
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    private static int Increment() => _value++;
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.csproj
new file mode 100644
index 00000000000000..f3e1cbd44b4041
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_55140/Runtime_55140.csproj
@@ -0,0 +1,12 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+  </PropertyGroup>
+  <PropertyGroup>
+    <DebugType>None</DebugType>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>