diff --git a/src/FSharpSource.targets b/src/FSharpSource.targets
index ab7250ea04b..b4c1c24825b 100644
--- a/src/FSharpSource.targets
+++ b/src/FSharpSource.targets
@@ -288,7 +288,7 @@
     <DefineConstants>$(DefineConstants);FX_NO_MISSINGMETHODEXCEPTION</DefineConstants>
     <DefineConstants>$(DefineConstants);DONT_INCLUDE_DEPRECATED</DefineConstants>
     <DefineConstants>$(DefineConstants);QUERIES_IN_FSLIB</DefineConstants>
-    <DefineConstants>$(DefineConstants);FX_NO_STRUCTTUPLE</DefineConstants>
+    <DefineConstants>$(DefineConstants);FX_ASSEMBLYLOADBYSTRING</DefineConstants>
     <TargetFrameworkProfile>Profile47</TargetFrameworkProfile>
     <TargetFrameworkVersion Condition="'$(TargetFrameworkVersion)' == ''">v4.0</TargetFrameworkVersion>
   </PropertyGroup>
diff --git a/src/fsharp/FSharp.Core/FSharp.Core.fsproj b/src/fsharp/FSharp.Core/FSharp.Core.fsproj
index 9cd792bcdd2..7b5d7b49cd9 100644
--- a/src/fsharp/FSharp.Core/FSharp.Core.fsproj
+++ b/src/fsharp/FSharp.Core/FSharp.Core.fsproj
@@ -214,10 +214,6 @@
     <Reference Include="System" />
     <Reference Include="System.Numerics" Condition="'$(TargetFramework)' == 'net40'" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' != 'portable47' and '$(TargetFramework)' != 'coreclr'">
-    <Reference Include="System.ValueTuple"><HintPath>..\..\..\packages\System.ValueTuple.4.0.0-rc3-24212-01\lib\netstandard1.1\System.ValueTuple.dll</HintPath></Reference>
-    <Reference Include="System.Runtime" />
-  </ItemGroup>
   <ItemGroup Condition="'$(TargetFramework)' == 'coreclr'">
     <None Include="project.json" />
   </ItemGroup>
diff --git a/src/fsharp/FSharp.Core/project.json b/src/fsharp/FSharp.Core/project.json
index b4105f53d65..9b310893e37 100644
--- a/src/fsharp/FSharp.Core/project.json
+++ b/src/fsharp/FSharp.Core/project.json
@@ -25,7 +25,6 @@
     "System.Threading.Thread": "4.0.0",
     "System.Threading.ThreadPool": "4.0.10",
     "System.Threading.Timer": "4.0.1",
-    "System.ValueTuple": "4.0.0-rc3-24212-01",
   },
   "runtimes": {
     "win7-x86": { },
diff --git a/src/fsharp/FSharp.Core/reflect.fs b/src/fsharp/FSharp.Core/reflect.fs
index adcacc2bd9f..509f352d647 100644
--- a/src/fsharp/FSharp.Core/reflect.fs
+++ b/src/fsharp/FSharp.Core/reflect.fs
@@ -395,10 +395,13 @@ module internal Impl =
 
     let mutable systemValueTupleException = null
 
-#if !FX_NO_STRUCTTUPLE
     let reflectedValueTuple n =
         try
+#if FX_ASSEMBLYLOADBYSTRING
+            let a = Assembly.Load("System.ValueTuple")
+#else
             let a = Assembly.Load(new AssemblyName("System.ValueTuple"))
+#endif
             match n with
             | 1 -> Some (a.GetType("System.ValueTuple`1"))
             | 2 -> Some (a.GetType("System.ValueTuple`2"))
@@ -446,7 +449,6 @@ module internal Impl =
     let isStructTuple6Type typ = structTupleEquivHeadTypes typ stuple6
     let isStructTuple7Type typ = structTupleEquivHeadTypes typ stuple7
     let isStructTuple8Type typ = structTupleEquivHeadTypes typ stuple8
-#endif
 
     let isTupleType typ = 
         let isRefTupleType = 
@@ -460,9 +462,6 @@ module internal Impl =
             || isTuple8Type typ
 
         let isStructTupleType =
-#if FX_NO_STRUCTTUPLE
-            false
-#else
             // If we can't load the System.ValueTuple Assembly then it can't be a struct tuple
             try
                    isStructTuple1Type typ
@@ -474,7 +473,6 @@ module internal Impl =
                 || isStructTuple7Type typ
                 || isStructTuple8Type typ
             with | :? System.IO.FileNotFoundException -> false
-#endif
         isRefTupleType || isStructTupleType
 
     let maxTuple = 8
@@ -482,7 +480,6 @@ module internal Impl =
     let tupleEncField = maxTuple-1
 
     let rec mkTupleType isStruct (tys: Type[]) =
-#if !FX_NO_STRUCTTUPLE
         let deOption (o: option<Type>) =
             match o with 
             | Some v -> v
@@ -503,7 +500,6 @@ module internal Impl =
                 deOption(stuple8).MakeGenericType(Array.append tysA [| tyB |])
             | _ -> invalidArg "tys" (SR.GetString(SR.invalidTupleTypes))
         else
-#endif
             match tys.Length with 
             | 1 -> tuple1.MakeGenericType(tys)
             | 2 -> tuple2.MakeGenericType(tys)