diff --git a/ethpm/constants.py b/ethpm/constants.py
index c895c4a591..c6818e5210 100644
--- a/ethpm/constants.py
+++ b/ethpm/constants.py
@@ -15,4 +15,5 @@
     3: "ropsten",
     4: "rinkeby",
     5: "goerli",
+    11155111: "sepolia",
 }
diff --git a/tests/ethpm/_utils/test_chain_utils.py b/tests/ethpm/_utils/test_chain_utils.py
index 92c2b00e52..096d8a51a1 100644
--- a/tests/ethpm/_utils/test_chain_utils.py
+++ b/tests/ethpm/_utils/test_chain_utils.py
@@ -49,6 +49,7 @@ def test_parse_BIP122_uri(value, expected_resource_type):
         (3, True),
         (4, True),
         (5, True),
+        (11155111, True),
         (2, False),
         ("1", False),
         ({}, False),
diff --git a/web3/auto/infura/endpoints.py b/web3/auto/infura/endpoints.py
index 55258f9a57..fa7ecb5df8 100644
--- a/web3/auto/infura/endpoints.py
+++ b/web3/auto/infura/endpoints.py
@@ -20,6 +20,7 @@
 INFURA_ROPSTEN_DOMAIN = "ropsten.infura.io"
 INFURA_GOERLI_DOMAIN = "goerli.infura.io"
 INFURA_RINKEBY_DOMAIN = "rinkeby.infura.io"
+INFURA_SEPOLIA_DOMAIN = "sepolia.infura.io"
 
 WEBSOCKET_SCHEME = "wss"
 HTTP_SCHEME = "https"
diff --git a/web3/auto/infura/sepolia.py b/web3/auto/infura/sepolia.py
new file mode 100644
index 0000000000..d7f128800c
--- /dev/null
+++ b/web3/auto/infura/sepolia.py
@@ -0,0 +1,15 @@
+from web3 import Web3
+from web3.providers.auto import (
+    load_provider_from_uri,
+)
+
+from .endpoints import (
+    INFURA_SEPOLIA_DOMAIN,
+    build_http_headers,
+    build_infura_url,
+)
+
+_headers = build_http_headers()
+_infura_url = build_infura_url(INFURA_SEPOLIA_DOMAIN)
+
+w3 = Web3(load_provider_from_uri(_infura_url, _headers))