diff --git a/packages/react-native/scripts/cocoapods/utils.rb b/packages/react-native/scripts/cocoapods/utils.rb
index 06c07b986a60b7..a41b2997888ae9 100644
--- a/packages/react-native/scripts/cocoapods/utils.rb
+++ b/packages/react-native/scripts/cocoapods/utils.rb
@@ -98,11 +98,12 @@ def self.set_ccache_compiler_and_linker_build_settings(installer, react_native_p
             Pod::UI.puts("#{message_prefix}: Ccache found at #{ccache_path}")
         end
 
+        # Using scripts wrapping the ccache executable, to allow injection of configurations
+        ccache_clang_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang.sh')
+        ccache_clangpp_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang++.sh')
+
         if ccache_available and ccache_enabled
             Pod::UI.puts("#{message_prefix}: Setting CC, LD, CXX & LDPLUSPLUS build settings")
-            # Using scripts wrapping the ccache executable, to allow injection of configurations
-            ccache_clang_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang.sh')
-            ccache_clangpp_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang++.sh')
 
             projects.each do |project|
                 project.build_configurations.each do |config|
@@ -119,6 +120,20 @@ def self.set_ccache_compiler_and_linker_build_settings(installer, react_native_p
             Pod::UI.puts("#{message_prefix}: Pass ':ccache_enabled => true' to 'react_native_post_install' in your Podfile or set environment variable 'USE_CCACHE=1' to increase the speed of subsequent builds")
         elsif !ccache_available and ccache_enabled
             Pod::UI.warn("#{message_prefix}: Install ccache or ensure your neither passing ':ccache_enabled => true' nor setting environment variable 'USE_CCACHE=1'")
+        else
+            Pod::UI.puts("#{message_prefix}: Removing Ccache from CC, LD, CXX & LDPLUSPLUS build settings")
+
+            projects.each do |project|
+                project.build_configurations.each do |config|
+                    # Using the un-qualified names means you can swap in different implementations, for example ccache
+                    config.build_settings["CC"] = config.build_settings["CC"] ? config.build_settings["CC"].gsub(/#{Regexp.escape(ccache_clang_sh)}/, '') : ""
+                    config.build_settings["LD"] = config.build_settings["LD"] ? config.build_settings["LD"].gsub(/#{Regexp.escape(ccache_clang_sh)}/, "") : ""
+                    config.build_settings["CXX"] = config.build_settings["CXX"] ? config.build_settings["CXX"].gsub(/#{Regexp.escape(ccache_clangpp_sh)}/, "") : ""
+                    config.build_settings["LDPLUSPLUS"] = config.build_settings["LDPLUSPLUS"] ? config.build_settings["LDPLUSPLUS"].gsub(/#{Regexp.escape(ccache_clangpp_sh)}/, "") : ""
+                end
+
+                project.save()
+            end
         end
     end