diff --git a/packages/utils/src/instrument.ts b/packages/utils/src/instrument.ts
index 157fe8a50c0b..f3364ba92b9c 100644
--- a/packages/utils/src/instrument.ts
+++ b/packages/utils/src/instrument.ts
@@ -247,8 +247,9 @@ export function parseFetchArgs(fetchArgs: unknown[]): { method: string; url: str
 }
 
 /** JSDoc */
-function instrumentXHR(): void {
-  if (!('XMLHttpRequest' in WINDOW)) {
+export function instrumentXHR(): void {
+  // eslint-disable-next-line @typescript-eslint/no-unsafe-member-access
+  if (!(WINDOW as any).XMLHttpRequest) {
     return;
   }
 
@@ -539,8 +540,8 @@ type InstrumentedElement = Element & {
 };
 
 /** JSDoc */
-function instrumentDOM(): void {
-  if (!('document' in WINDOW)) {
+export function instrumentDOM(): void {
+  if (!WINDOW.document) {
     return;
   }
 
diff --git a/packages/utils/test/instrument.test.ts b/packages/utils/test/instrument.test.ts
index f9088ca1257a..f1ec46b93fb1 100644
--- a/packages/utils/test/instrument.test.ts
+++ b/packages/utils/test/instrument.test.ts
@@ -1,6 +1,22 @@
-import { parseFetchArgs } from '../src/instrument';
+import { instrumentDOM, instrumentXHR, parseFetchArgs } from '../src/instrument';
+
+jest.mock('../src/worldwide', () => ({
+  // Return an empty object with undefined properties
+  getGlobalObject: () => ({
+    document: undefined,
+    XMLHttpRequest: undefined,
+  }),
+}));
 
 describe('instrument', () => {
+  it('instrumentXHR() does not throw if XMLHttpRequest is a key on window but not defined', () => {
+    expect(instrumentXHR).not.toThrow();
+  });
+
+  it('instrumentDOM() does not throw if XMLHttpRequest is a key on window but not defined', () => {
+    expect(instrumentDOM).not.toThrow();
+  });
+
   describe('parseFetchArgs', () => {
     it.each([
       ['string URL only', ['http://example.com'], { method: 'GET', url: 'http://example.com' }],