diff --git a/pkg/distributor/errors.go b/pkg/distributor/errors.go
index f61a23ff3ec..115585b6979 100644
--- a/pkg/distributor/errors.go
+++ b/pkg/distributor/errors.go
@@ -248,6 +248,8 @@ func toGRPCError(pushErr error, serviceOverloadErrorEnabled bool) error {
 			errCode = codes.FailedPrecondition
 		case mimirpb.CIRCUIT_BREAKER_OPEN:
 			errCode = codes.Unavailable
+		case mimirpb.METHOD_NOT_ALLOWED:
+			errCode = codes.Unimplemented
 		}
 	}
 	stat := status.New(errCode, pushErr.Error())
@@ -296,7 +298,11 @@ func wrapPartitionPushError(err error, partitionID int32) error {
 func isIngesterClientError(err error) bool {
 	var ingesterPushErr ingesterPushError
 	if errors.As(err, &ingesterPushErr) {
-		return ingesterPushErr.errorCause() == mimirpb.BAD_DATA
+		switch ingesterPushErr.errorCause() {
+		case mimirpb.BAD_DATA, mimirpb.METHOD_NOT_ALLOWED:
+			return true
+		}
+		return false
 	}
 
 	// This code is needed for backwards compatibility, since ingesters may still return errors with HTTP status
diff --git a/pkg/distributor/errors_test.go b/pkg/distributor/errors_test.go
index ddc0b94c471..0d95b96f030 100644
--- a/pkg/distributor/errors_test.go
+++ b/pkg/distributor/errors_test.go
@@ -364,6 +364,18 @@ func TestToGRPCError(t *testing.T) {
 			expectedErrorMsg:     fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, circuitbreaker.ErrOpen),
 			expectedErrorDetails: &mimirpb.ErrorDetails{Cause: mimirpb.CIRCUIT_BREAKER_OPEN},
 		},
+		"an ingesterPushError with METHOD_NOT_ALLOWED cause gets translated into a Unimplemented error with METHOD_NOT_ALLOWED cause": {
+			err:                  newIngesterPushError(createStatusWithDetails(t, codes.Unimplemented, originalMsg, mimirpb.METHOD_NOT_ALLOWED), ingesterID),
+			expectedGRPCCode:     codes.Unimplemented,
+			expectedErrorMsg:     fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, originalMsg),
+			expectedErrorDetails: &mimirpb.ErrorDetails{Cause: mimirpb.METHOD_NOT_ALLOWED},
+		},
+		"a DoNotLogError of an ingesterPushError with METHOD_NOT_ALLOWED cause gets translated into a Unimplemented error with METHOD_NOT_ALLOWED cause": {
+			err:                  middleware.DoNotLogError{Err: newIngesterPushError(createStatusWithDetails(t, codes.Unimplemented, originalMsg, mimirpb.METHOD_NOT_ALLOWED), ingesterID)},
+			expectedGRPCCode:     codes.Unimplemented,
+			expectedErrorMsg:     fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, originalMsg),
+			expectedErrorDetails: &mimirpb.ErrorDetails{Cause: mimirpb.METHOD_NOT_ALLOWED},
+		},
 	}
 	for name, tc := range testCases {
 		t.Run(name, func(t *testing.T) {
@@ -486,7 +498,11 @@ func TestIsIngesterClientError(t *testing.T) {
 			err:             ingesterPushError{cause: mimirpb.BAD_DATA},
 			expectedOutcome: true,
 		},
-		"an ingesterPushError with error cause different from BAD_DATA is not a client error": {
+		"an ingesterPushError with error cause METHOD_NOT_ALLOWED is a client error": {
+			err:             ingesterPushError{cause: mimirpb.METHOD_NOT_ALLOWED},
+			expectedOutcome: true,
+		},
+		"an ingesterPushError with other error cause is not a client error": {
 			err:             ingesterPushError{cause: mimirpb.SERVICE_UNAVAILABLE},
 			expectedOutcome: false,
 		},
diff --git a/pkg/distributor/push.go b/pkg/distributor/push.go
index 440ad1cb536..4df320efd4f 100644
--- a/pkg/distributor/push.go
+++ b/pkg/distributor/push.go
@@ -228,6 +228,8 @@ func toHTTPStatus(ctx context.Context, pushErr error, limits *validation.Overrid
 			return http.StatusServiceUnavailable
 		case mimirpb.CIRCUIT_BREAKER_OPEN:
 			return http.StatusServiceUnavailable
+		case mimirpb.METHOD_NOT_ALLOWED:
+			return http.StatusMethodNotAllowed
 		}
 	}
 
diff --git a/pkg/distributor/push_test.go b/pkg/distributor/push_test.go
index 43840faeaa8..7e443e55f9f 100644
--- a/pkg/distributor/push_test.go
+++ b/pkg/distributor/push_test.go
@@ -1091,6 +1091,16 @@ func TestHandler_ToHTTPStatus(t *testing.T) {
 			expectedHTTPStatus: http.StatusBadRequest,
 			expectedErrorMsg:   fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, originalMsg),
 		},
+		"an ingesterPushError with METHOD_NOT_ALLOWED cause gets translated into an HTTP 405": {
+			err:                newIngesterPushError(createStatusWithDetails(t, codes.Unimplemented, originalMsg, mimirpb.METHOD_NOT_ALLOWED), ingesterID),
+			expectedHTTPStatus: http.StatusMethodNotAllowed,
+			expectedErrorMsg:   fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, originalMsg),
+		},
+		"a DoNotLogError of an ingesterPushError with METHOD_NOT_ALLOWED cause gets translated into an HTTP 405": {
+			err:                middleware.DoNotLogError{Err: newIngesterPushError(createStatusWithDetails(t, codes.Unimplemented, originalMsg, mimirpb.METHOD_NOT_ALLOWED), ingesterID)},
+			expectedHTTPStatus: http.StatusMethodNotAllowed,
+			expectedErrorMsg:   fmt.Sprintf("%s %s: %s", failedPushingToIngesterMessage, ingesterID, originalMsg),
+		},
 		"an ingesterPushError with TSDB_UNAVAILABLE cause gets translated into an HTTP 503": {
 			err:                newIngesterPushError(createStatusWithDetails(t, codes.Internal, originalMsg, mimirpb.TSDB_UNAVAILABLE), ingesterID),
 			expectedHTTPStatus: http.StatusServiceUnavailable,
diff --git a/pkg/ruler/compat_test.go b/pkg/ruler/compat_test.go
index 5de40bc2386..c51bd33a41c 100644
--- a/pkg/ruler/compat_test.go
+++ b/pkg/ruler/compat_test.go
@@ -238,6 +238,11 @@ func TestPusherErrors(t *testing.T) {
 			expectedWrites:   1,
 			expectedFailures: 0,
 		},
+		"a METHOD_NOT_ALLOWED push error is reported as failure": {
+			returnedError:    mustStatusWithDetails(codes.Unimplemented, mimirpb.METHOD_NOT_ALLOWED).Err(),
+			expectedWrites:   1,
+			expectedFailures: 1,
+		},
 		"a TSDB_UNAVAILABLE push error is reported as failure": {
 			returnedError:    mustStatusWithDetails(codes.FailedPrecondition, mimirpb.TSDB_UNAVAILABLE).Err(),
 			expectedWrites:   1,