diff --git a/.changelog/34770.txt b/.changelog/34770.txt
new file mode 100644
index 00000000000..0d154a795eb
--- /dev/null
+++ b/.changelog/34770.txt
@@ -0,0 +1,3 @@
+```release-note:bug
+resource/aws_appflow_flow: Fix perpetual diff on `destination_flow_config`
+```
\ No newline at end of file
diff --git a/internal/service/appflow/flow.go b/internal/service/appflow/flow.go
index 0ad6d73500b..4f807f3b754 100644
--- a/internal/service/appflow/flow.go
+++ b/internal/service/appflow/flow.go
@@ -56,7 +56,7 @@ func resourceFlow() *schema.Resource {
 				ValidateFunc: validation.StringMatch(regexache.MustCompile(`[\w!@#\-.?,\s]*`), "must contain only alphanumeric, underscore (_), exclamation point (!), at sign (@), number sign (#), hyphen (-), period (.), question mark (?), comma (,), and whitespace characters"),
 			},
 			"destination_flow_config": {
-				Type:     schema.TypeSet,
+				Type:     schema.TypeList,
 				Required: true,
 				Elem: &schema.Resource{
 					Schema: map[string]*schema.Schema{
@@ -331,6 +331,7 @@ func resourceFlow() *schema.Resource {
 									"s3": {
 										Type:     schema.TypeList,
 										Optional: true,
+										Computed: true,
 										MaxItems: 1,
 										Elem: &schema.Resource{
 											Schema: map[string]*schema.Schema{
@@ -342,23 +343,27 @@ func resourceFlow() *schema.Resource {
 												"bucket_prefix": {
 													Type:         schema.TypeString,
 													Optional:     true,
+													Computed:     true,
 													ValidateFunc: validation.StringLenBetween(0, 512),
 												},
 												"s3_output_format_config": {
 													Type:     schema.TypeList,
 													Optional: true,
+													Computed: true,
 													MaxItems: 1,
 													Elem: &schema.Resource{
 														Schema: map[string]*schema.Schema{
 															"aggregation_config": {
 																Type:     schema.TypeList,
 																Optional: true,
+																Computed: true,
 																MaxItems: 1,
 																Elem: &schema.Resource{
 																	Schema: map[string]*schema.Schema{
 																		"aggregation_type": {
 																			Type:             schema.TypeString,
 																			Optional:         true,
+																			Computed:         true,
 																			ValidateDiagFunc: enum.Validate[types.AggregationType](),
 																		},
 																	},
@@ -372,6 +377,7 @@ func resourceFlow() *schema.Resource {
 															"prefix_config": {
 																Type:     schema.TypeList,
 																Optional: true,
+																Computed: true,
 																MaxItems: 1,
 																Elem: &schema.Resource{
 																	Schema: map[string]*schema.Schema{
@@ -391,6 +397,7 @@ func resourceFlow() *schema.Resource {
 															"preserve_source_data_typing": {
 																Type:     schema.TypeBool,
 																Optional: true,
+																Computed: true,
 															},
 														},
 													},
@@ -853,17 +860,20 @@ func resourceFlow() *schema.Resource {
 									"s3": {
 										Type:     schema.TypeList,
 										Optional: true,
+										Computed: true,
 										MaxItems: 1,
 										Elem: &schema.Resource{
 											Schema: map[string]*schema.Schema{
 												"bucket_name": {
 													Type:         schema.TypeString,
 													Required:     true,
+													ForceNew:     true,
 													ValidateFunc: validation.All(validation.StringMatch(regexache.MustCompile(`\S+`), "must not contain any whitespace characters"), validation.StringLenBetween(3, 63)),
 												},
 												"bucket_prefix": {
 													Type:         schema.TypeString,
-													Optional:     true,
+													Required:     true,
+													ForceNew:     true,
 													ValidateFunc: validation.StringLenBetween(0, 512),
 												},
 												"s3_input_format_config": {
@@ -1232,7 +1242,7 @@ func resourceFlowCreate(ctx context.Context, d *schema.ResourceData, meta interf
 	name := d.Get(names.AttrName).(string)
 	input := &appflow.CreateFlowInput{
 		FlowName:                  aws.String(name),
-		DestinationFlowConfigList: expandDestinationFlowConfigs(d.Get("destination_flow_config").(*schema.Set).List()),
+		DestinationFlowConfigList: expandDestinationFlowConfigs(d.Get("destination_flow_config").([]interface{})),
 		SourceFlowConfig:          expandSourceFlowConfig(d.Get("source_flow_config").([]interface{})[0].(map[string]interface{})),
 		Tags:                      getTagsIn(ctx),
 		Tasks:                     expandTasks(d.Get("task").(*schema.Set).List()),
@@ -1318,7 +1328,7 @@ func resourceFlowUpdate(ctx context.Context, d *schema.ResourceData, meta interf
 
 	if d.HasChangesExcept("tags", "tags_all") {
 		input := &appflow.UpdateFlowInput{
-			DestinationFlowConfigList: expandDestinationFlowConfigs(d.Get("destination_flow_config").(*schema.Set).List()),
+			DestinationFlowConfigList: expandDestinationFlowConfigs(d.Get("destination_flow_config").([]interface{})),
 			FlowName:                  aws.String(d.Get(names.AttrName).(string)),
 			SourceFlowConfig:          expandSourceFlowConfig(d.Get("source_flow_config").([]interface{})[0].(map[string]interface{})),
 			Tasks:                     expandTasks(d.Get("task").(*schema.Set).List()),