diff --git a/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListCoordinator.java b/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListCoordinator.java
index d89d555c4e26f9..db7231329c196e 100644
--- a/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListCoordinator.java
+++ b/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListCoordinator.java
@@ -30,6 +30,7 @@
 import androidx.recyclerview.widget.RecyclerView.OnItemTouchListener;
 
 import org.chromium.base.Callback;
+import org.chromium.base.Log;
 import org.chromium.base.TraceEvent;
 import org.chromium.base.supplier.ObservableSupplier;
 import org.chromium.base.supplier.Supplier;
@@ -62,6 +63,8 @@
 /** Coordinator for showing UI for a list of tabs. Can be used in GRID or STRIP modes. */
 public class TabListCoordinator
         implements PriceMessageService.PriceWelcomeMessageProvider, DestroyObserver {
+    private static final String TAG = "TabListCoordinator";
+
     /**
      * Modes of showing the list of tabs.
      *
@@ -483,7 +486,15 @@ Size getThumbnailSize() {
     }
 
     void waitForLayoutWithTab(int tabId, Runnable r) {
-        assert mAwaitingLayoutRunnable == null;
+        // Very fast navigations to/from the tab list may not have time for a layout to reach a
+        // completed state. Since this is primarily used for cancellable or skippable animations
+        // where the runnable will not be serviced downstream, dropping the runnable altogether is
+        // safe.
+        if (mAwaitingLayoutRunnable != null) {
+            Log.d(TAG, "Dropping AwaitingLayoutRunnable for " + mAwaitingTabId);
+            mAwaitingLayoutRunnable = null;
+            mAwaitingTabId = Tab.INVALID_TAB_ID;
+        }
         int index = getIndexForTabId(tabId);
         if (index == TabModel.INVALID_TAB_INDEX) {
             r.run();
diff --git a/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListRecyclerView.java b/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListRecyclerView.java
index 20019899b67165..19ca400fa09edb 100644
--- a/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListRecyclerView.java
+++ b/chrome/android/features/tab_ui/java/src/org/chromium/chrome/browser/tasks/tab_management/TabListRecyclerView.java
@@ -40,6 +40,7 @@
 import androidx.recyclerview.widget.RecyclerView;
 
 import org.chromium.base.Log;
+import org.chromium.chrome.browser.hub.HubFieldTrial;
 import org.chromium.chrome.browser.tabmodel.TabModel;
 import org.chromium.chrome.tab_ui.R;
 import org.chromium.ui.base.ViewUtils;
@@ -182,9 +183,15 @@ protected void onLayout(boolean changed, int l, int t, int r, int b) {
      * @param runnable the runnable that executes on next layout.
      */
     void runAnimationOnNextLayout(Runnable runnable) {
-        assert mOnNextLayoutRunnable == null
-                : "TabListRecyclerView animation on next layout set multiple times without"
-                        + " running.";
+        // Very fast navigations to/from the tab list may not have time for a layout to reach a
+        // completed state. Since this is primarily used for cancellable or skippable animations
+        // where the runnable will not be serviced downstream, dropping the runnable altogether is
+        // safe for Hub.
+        if (!HubFieldTrial.isHubEnabled()) {
+            assert mOnNextLayoutRunnable == null
+                    : "TabListRecyclerView animation on next layout set multiple times without"
+                            + " running.";
+        }
         mOnNextLayoutRunnable =
                 () -> {
                     if (mDynamicView == null) {