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Copy pathEc_core_flux1.xml
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Ec_core_flux1.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="Ec_core" name="Ec_core">
<listOfUnitDefinitions>
<unitDefinition id="mmol_per_gDW_per_hr">
<listOfUnits>
<unit kind="mole" scale="-3"/>
<unit kind="gram" exponent="-1"/>
<unit kind="second" multiplier=".00027777" exponent="-1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="Extra_organism"/>
<compartment id="Cytosol" outside="Extra_organism"/>
</listOfCompartments>
<listOfSpecies>
<species id="M_13dpg_c" name="M_3_Phospho_D_glyceroyl_phosphate_C3H4O10P2" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_2pg_c" name="M_D_Glycerate_2_phosphate_C3H4O7P" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_3pg_c" name="M_3_Phospho_D_glycerate_C3H4O7P" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_6pgc_c" name="M_6_Phospho_D_gluconate_C6H10O10P" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_6pgl_c" name="M_6_phospho_D_glucono_1_5_lactone_C6H9O9P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_ac_c" name="M_Acetate_C2H3O2" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_ac_e" name="M_Acetate_C2H3O2" compartment="Extra_organism" charge="-1" boundaryCondition="false"/>
<species id="M_accoa_c" name="M_Acetyl_CoA_C23H34N7O17P3S" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_actp_c" name="M_Acetyl_phosphate_C2H3O5P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_adp_c" name="M_ADP_C10H12N5O10P2" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_akg_c" name="M_2_Oxoglutarate_C5H4O5" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_akg_e" name="M_2_Oxoglutarate_C5H4O5" compartment="Extra_organism" charge="-2" boundaryCondition="false"/>
<species id="M_amp_c" name="M_AMP_C10H12N5O7P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_atp_c" name="M_ATP_C10H12N5O13P3" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_cit_c" name="M_Citrate_C6H5O7" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_co2_c" name="M_CO2_CO2" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_co2_e" name="M_CO2_CO2" compartment="Extra_organism" charge="0" boundaryCondition="false"/>
<species id="M_coa_c" name="M_Coenzyme_A_C21H32N7O16P3S" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_dhap_c" name="M_Dihydroxyacetone_phosphate_C3H5O6P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_e4p_c" name="M_D_Erythrose_4_phosphate_C4H7O7P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_etoh_c" name="M_Ethanol_C2H6O" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_etoh_e" name="M_Ethanol_C2H6O" compartment="Extra_organism" charge="0" boundaryCondition="false"/>
<species id="M_f6p_c" name="M_D_Fructose_6_phosphate_C6H11O9P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_fad_c" name="M_Flavin_adenine_dinucleotide_oxidized_C27H31N9O15P2" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_fadh2_c" name="M_Flavin_adenine_dinucleotide_reduced_C27H33N9O15P2" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_fdp_c" name="M_D_Fructose_1_6_bisphosphate_C6H10O12P2" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_for_c" name="M_Formate_CH1O2" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_for_e" name="M_Formate_CH1O2" compartment="Extra_organism" charge="-1" boundaryCondition="false"/>
<species id="M_fum_c" name="M_Fumarate_C4H2O4" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_fum_e" name="M_Fumarate_C4H2O4" compartment="Extra_organism" charge="-2" boundaryCondition="false"/>
<species id="M_g3p_c" name="M_Glyceraldehyde_3_phosphate_C3H5O6P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_g6p_c" name="M_D_Glucose_6_phosphate_C6H11O9P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_glc_D_e" name="M_D_Glucose_C6H12O6" compartment="Extra_organism" charge="0" boundaryCondition="false"/>
<species id="M_glx_c" name="M_Glyoxylate_C2H1O3" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_h2o_c" name="M_H2O_H2O" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_h2o_e" name="M_H2O_H2O" compartment="Extra_organism" charge="0" boundaryCondition="false"/>
<species id="M_h_c" name="M_H_H" compartment="Cytosol" charge="1" boundaryCondition="false"/>
<species id="M_h_e" name="M_H_H" compartment="Extra_organism" charge="1" boundaryCondition="false"/>
<species id="M_icit_c" name="M_Isocitrate_C6H5O7" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_lac_D_c" name="M_D_Lactate_C3H5O3" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_lac_D_e" name="M_D_Lactate_C3H5O3" compartment="Extra_organism" charge="-1" boundaryCondition="false"/>
<species id="M_mal_L_c" name="M_L_Malate_C4H4O5" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_nad_c" name="M_Nicotinamide_adenine_dinucleotide_C21H26N7O14P2" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_nadh_c" name="M_Nicotinamide_adenine_dinucleotide___reduced_C21H27N7O14P2" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_nadp_c" name="M_Nicotinamide_adenine_dinucleotide_phosphate_C21H25N7O17P3" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_nadph_c" name="M_Nicotinamide_adenine_dinucleotide_phosphate___reduced_C21H26N7O17P3" compartment="Cytosol" charge="-4" boundaryCondition="false"/>
<species id="M_o2_c" name="M_O2_O2" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_o2_e" name="M_O2_O2" compartment="Extra_organism" charge="0" boundaryCondition="false"/>
<species id="M_oaa_c" name="M_Oxaloacetate_C4H2O5" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_pep_c" name="M_Phosphoenolpyruvate_C3H2O6P" compartment="Cytosol" charge="-3" boundaryCondition="false"/>
<species id="M_pi_c" name="M_Phosphate_HO4P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_pi_e" name="M_Phosphate_HO4P" compartment="Extra_organism" charge="-2" boundaryCondition="false"/>
<species id="M_pyr_c" name="M_Pyruvate_C3H3O3" compartment="Cytosol" charge="-1" boundaryCondition="false"/>
<species id="M_pyr_e" name="M_Pyruvate_C3H3O3" compartment="Extra_organism" charge="-1" boundaryCondition="false"/>
<species id="M_q8_c" name="M_Ubiquinone_8_C49H74O4" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_q8h2_c" name="M_Ubiquinol_8_C49H76O4" compartment="Cytosol" charge="0" boundaryCondition="false"/>
<species id="M_r5p_c" name="M_alpha_D_Ribose_5_phosphate_C5H9O8P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_ru5p_D_c" name="M_D_Ribulose_5_phosphate_C5H9O8P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_s7p_c" name="M_Sedoheptulose_7_phosphate_C7H13O10P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_succ_c" name="M_Succinate_C4H4O4" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_succ_e" name="M_Succinate_C4H4O4" compartment="Extra_organism" charge="-2" boundaryCondition="false"/>
<species id="M_succoa_c" name="M_Succinyl_CoA_C25H35N7O19P3S" compartment="Cytosol" charge="-5" boundaryCondition="false"/>
<species id="M_xu5p_D_c" name="M_D_Xylulose_5_phosphate_C5H9O8P" compartment="Cytosol" charge="-2" boundaryCondition="false"/>
<species id="M_ac_b" name="M_Acetate_C2H3O2" compartment="Extra_organism" charge="-1" boundaryCondition="true"/>
<species id="M_akg_b" name="M_2_Oxoglutarate_C5H4O5" compartment="Extra_organism" charge="-2" boundaryCondition="true"/>
<species id="M_co2_b" name="M_CO2_CO2" compartment="Extra_organism" charge="0" boundaryCondition="true"/>
<species id="M_etoh_b" name="M_Ethanol_C2H6O" compartment="Extra_organism" charge="0" boundaryCondition="true"/>
<species id="M_for_b" name="M_Formate_CH1O2" compartment="Extra_organism" charge="-1" boundaryCondition="true"/>
<species id="M_fum_b" name="M_Fumarate_C4H2O4" compartment="Extra_organism" charge="-2" boundaryCondition="true"/>
<species id="M_glc_D_b" name="M_D_Glucose_C6H12O6" compartment="Extra_organism" charge="0" boundaryCondition="true"/>
<species id="M_h2o_b" name="M_H2O_H2O" compartment="Extra_organism" charge="0" boundaryCondition="true"/>
<species id="M_h_b" name="M_H_H" compartment="Extra_organism" charge="1" boundaryCondition="true"/>
<species id="M_lac_D_b" name="M_D_Lactate_C3H5O3" compartment="Extra_organism" charge="-1" boundaryCondition="true"/>
<species id="M_o2_b" name="M_O2_O2" compartment="Extra_organism" charge="0" boundaryCondition="true"/>
<species id="M_pi_b" name="M_Phosphate_HO4P" compartment="Extra_organism" charge="-2" boundaryCondition="true"/>
<species id="M_pyr_b" name="M_Pyruvate_C3H3O3" compartment="Extra_organism" charge="-1" boundaryCondition="true"/>
<species id="M_succ_b" name="M_Succinate_C4H4O4" compartment="Extra_organism" charge="-2" boundaryCondition="true"/>
</listOfSpecies>
<listOfReactions>
<reaction id="R_ACKr" name="R_acetate_kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: b2296</html:p>
<html:p>PROTEIN_ASSOCIATION: AckA</html:p>
<html:p>SUBSYSTEM: S_Pyruvate_Metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
</notes>
<listOfReactants>
<speciesReference species="M_ac_c" stoichiometry="1.000000"/>
<speciesReference species="M_atp_c" stoichiometry="1.000000"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="M_actp_c" stoichiometry="1.000000"/>
<speciesReference species="M_adp_c" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
</math>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="0.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="REDUCED_COST" value="0.000000"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="R_ACONT" name="R_aconitase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( b0118 or b1276 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AcnB ) or ( AcnA )</html:p>
<html:p>SUBSYSTEM: S_Citric_Acid_Cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
</notes>
<listOfReactants>
<speciesReference species="M_cit_c" stoichiometry="1.000000"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="M_icit_c" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
</math>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="6.264896" units="mmol_per_gDW_per_hr"/>
<parameter id="REDUCED_COST" value="0.000000"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="R_ACt2r" name="R_acetate_reversible_transport_via_proton_symport" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_ac_e" stoichiometry="1.000000"/>
<speciesReference species="M_h_e" stoichiometry="1.000000"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="M_ac_c" stoichiometry="1.000000"/>
<speciesReference species="M_h_c" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
</math>
<listOfParameters>
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<reaction id="R_ADHEr" name="R_Acetaldehyde_dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: b1241</html:p>
<html:p>PROTEIN_ASSOCIATION: AdhE</html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_accoa_c" stoichiometry="1.000000"/>
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<speciesReference species="M_nadh_c" stoichiometry="2.000000"/>
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<ci> FLUX_VALUE </ci>
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<reaction id="R_ADK1" name="R_adenylate_kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: b0474</html:p>
<html:p>PROTEIN_ASSOCIATION: Adk</html:p>
<html:p>SUBSYSTEM: S_Oxidative_Phosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.3</html:p>
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<speciesReference species="M_amp_c" stoichiometry="1.000000"/>
<speciesReference species="M_atp_c" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_adp_c" stoichiometry="2.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
<parameter id="LOWER_BOUND" value="-999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: ( b0116 and b0726 and b0727 )</html:p>
<html:p>PROTEIN_ASSOCIATION: SucA</html:p>
<html:p>SUBSYSTEM: S_Citric_Acid_Cycle</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_akg_c" stoichiometry="1.000000"/>
<speciesReference species="M_coa_c" stoichiometry="1.000000"/>
<speciesReference species="M_nad_c" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_co2_c" stoichiometry="1.000000"/>
<speciesReference species="M_nadh_c" stoichiometry="1.000000"/>
<speciesReference species="M_succoa_c" stoichiometry="1.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<reaction id="R_AKGt2r" name="R_2_oxoglutarate_reversible_transport_via_symport" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: b2587</html:p>
<html:p>PROTEIN_ASSOCIATION: KgtPec</html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_akg_e" stoichiometry="1.000000"/>
<speciesReference species="M_h_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<speciesReference species="M_h_c" stoichiometry="1.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_Oxidative_Phosphorylation</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_atp_c" stoichiometry="1.000000"/>
<speciesReference species="M_h2o_c" stoichiometry="1.000000"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<parameter id="UPPER_BOUND" value="7.600000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: ( ( b3736 and b3737 and b3738 ) and ( b3731 and b3732 and b3733 and b3734 and b3735 ) and b3739 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AtpF0 and AtpF1 and AtpI )</html:p>
<html:p>SUBSYSTEM: S_Oxidative_Phosphorylation</html:p>
<html:p>PROTEIN_CLASS: 3.6.3.14</html:p>
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<listOfReactants>
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<ci> FLUX_VALUE </ci>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: </html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<speciesReference species="M_3pg_c" stoichiometry="1.496000"/>
<speciesReference species="M_accoa_c" stoichiometry="3.747800"/>
<speciesReference species="M_akg_c" stoichiometry="1.078900"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_co2_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<notes>
<html:p>GENE_ASSOCIATION: b0720</html:p>
<html:p>PROTEIN_ASSOCIATION: GltA</html:p>
<html:p>SUBSYSTEM: S_Citric_Acid_Cycle</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_accoa_c" stoichiometry="1.000000"/>
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<html:p>GENE_ASSOCIATION: ( b0429 and b0430 and b0431 and b0432 )</html:p>
<html:p>PROTEIN_ASSOCIATION: CyoA</html:p>
<html:p>SUBSYSTEM: S_Oxidative_Phosphorylation</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<ci> FLUX_VALUE </ci>
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<notes>
<html:p>GENE_ASSOCIATION: ( b2975 or b3603 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlcA ) or ( LldP )</html:p>
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<html:p>PROTEIN_CLASS: </html:p>
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<speciesReference species="M_h_e" stoichiometry="1.000000"/>
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<speciesReference species="M_lac_D_c" stoichiometry="1.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<notes>
<html:p>GENE_ASSOCIATION: b2779</html:p>
<html:p>PROTEIN_ASSOCIATION: Eno</html:p>
<html:p>SUBSYSTEM: S_GlycolysisGluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
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<listOfReactants>
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<ci> FLUX_VALUE </ci>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
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<ci> FLUX_VALUE </ci>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_ac_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<ci> FLUX_VALUE </ci>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<speciesReference species="M_akg_e" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_akg_b" stoichiometry="1.000000"/>
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<kineticLaw>
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<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_co2_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_etoh_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<ci> FLUX_VALUE </ci>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<reaction id="R_EX_for_e_" name="R_Formate_exchange" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_for_e" stoichiometry="1.000000"/>
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<listOfProducts>
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</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
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<reaction id="R_EX_fum_e_" name="R_Fumarate_exchange" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_fum_e" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_fum_b" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
</math>
<listOfParameters>
<parameter id="LOWER_BOUND" value="0.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="0.000000" units="mmol_per_gDW_per_hr"/>
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<reaction id="R_EX_glc_e_" name="R_D_Glucose_exchange" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_glc_D_e" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_glc_D_b" stoichiometry="1.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
<parameter id="LOWER_BOUND" value="-10.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<parameter id="FLUX_VALUE" value="-10.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
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<listOfReactants>
<speciesReference species="M_h2o_e" stoichiometry="1.000000"/>
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<listOfProducts>
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</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<parameter id="LOWER_BOUND" value="-999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="24.920131" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_h_e" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_h_b" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="9.112915" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_lac_D_e" stoichiometry="1.000000"/>
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<listOfProducts>
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</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_o2_e" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_o2_b" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="-22.346504" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_pi_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="-3.168859" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_pyr_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
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<notes>
<html:p>GENE_ASSOCIATION: </html:p>
<html:p>PROTEIN_ASSOCIATION: </html:p>
<html:p>SUBSYSTEM: S_</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_succ_e" stoichiometry="1.000000"/>
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<listOfProducts>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: b2925</html:p>
<html:p>PROTEIN_ASSOCIATION: FbaA</html:p>
<html:p>SUBSYSTEM: S_GlycolysisGluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
</notes>
<listOfReactants>
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<listOfProducts>
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<speciesReference species="M_g3p_c" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
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<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
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<notes>
<html:p>GENE_ASSOCIATION: b4232</html:p>
<html:p>PROTEIN_ASSOCIATION: Fbp</html:p>
<html:p>SUBSYSTEM: S_GlycolysisGluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
</notes>
<listOfReactants>
<speciesReference species="M_fdp_c" stoichiometry="1.000000"/>
<speciesReference species="M_h2o_c" stoichiometry="1.000000"/>
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<listOfProducts>
<speciesReference species="M_f6p_c" stoichiometry="1.000000"/>
<speciesReference species="M_pi_c" stoichiometry="1.000000"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> FLUX_VALUE </ci>
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<listOfParameters>
<parameter id="LOWER_BOUND" value="0.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="999999.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0.000000"/>
<parameter id="FLUX_VALUE" value="0.000000" units="mmol_per_gDW_per_hr"/>
<parameter id="REDUCED_COST" value="-0.005805"/>
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<reaction id="R_FORt" name="R_formate_transport_via_diffusion" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: b0904</html:p>
<html:p>PROTEIN_ASSOCIATION: FocA</html:p>
<html:p>SUBSYSTEM: S_Transport__Extracellular</html:p>
<html:p>PROTEIN_CLASS: </html:p>
</notes>
<listOfReactants>
<speciesReference species="M_for_e" stoichiometry="1.000000"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="M_for_c" stoichiometry="1.000000"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">