From 330288bdc7c4da6e1a85217b9ef1a06cebdc17ee Mon Sep 17 00:00:00 2001 From: Julian Stamp Date: Mon, 16 Oct 2023 12:07:11 -0400 Subject: [PATCH] MM-120 fix Bonferroni correction --- data-raw/mvmapit_on_simulated_data.R | 2 +- data/mvmapit_data.rda | Bin 60092 -> 59937 bytes vignettes/mvMAPIT.Rmd | 8 ++++---- 3 files changed, 5 insertions(+), 5 deletions(-) diff --git a/data-raw/mvmapit_on_simulated_data.R b/data-raw/mvmapit_on_simulated_data.R index d33e693..7e0933d 100644 --- a/data-raw/mvmapit_on_simulated_data.R +++ b/data-raw/mvmapit_on_simulated_data.R @@ -22,7 +22,7 @@ mvmapit_hybrid <- mvmapit( fisher <- fishers_combined(mvmapit_hybrid$pvalues) # exhaustive search for p-values -thresh <- 0.05 / nrow(X) # Set a significance threshold +thresh <- 0.05 / nrow(t(X)) # Set a significance threshold significant_snps <- fisher %>% filter(p < thresh) # Call only marginally significant SNPs diff --git a/data/mvmapit_data.rda b/data/mvmapit_data.rda index 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zd)?@-%g_vGilUyt#XLq=An+m3JOCe6LIFCPL)ha=>&H@Gh>oU_L*Dpphcn)ciDG0v zq6C>L)1l&g`oyb&hFLgLpfU_KTZ(1CMOgpER-m${>iMDY)pv@m!f8f{0IjyNLlqRW zwyJ$Vh0C-Oalhy=OH&_$+CR>nnX<-ptim%$K5)WG+y3lxvc0ii9uNjfhx8lJ?axwF zvUalubFg#&U;reqd%%0Zd)SKp?&}`oYvSu#%opq+7RC8Q2wMen%i#ce1Oo|jpczY zy_7OgCvh{{Rr^{>jvn4Hl_aAAc-&~;ZGJDl3t_J{!k42lecG%y^^?dpWA~j@D1d?2 z6X6ofSMkNiiAl=&y4_% filter(p < thresh) # Call only marginally significant SNPs @@ -179,11 +179,11 @@ plot(tiles) ``` The only significant interactions after multiple testing correction are the interaction -between `snp00068` and `snp_00665` as well as `snp_00465` and `snp_00917`. +between `snp00068` and `snp_00665` as well as `snp_00469` and `snp_00917`. ```{r significant_exhaustive} pairs %>% - filter(p_01 < 0.05/15 | p_02 < 0.05/15) %>% + filter(p_01 < 0.05/nrow(pairs) | p_02 < 0.05/nrow(pairs)) %>% kable(., linesep = "", digits = 14) %>% kable_material(c("striped")) ```