diff --git a/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCProxies.java b/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCProxies.java
new file mode 100644
index 00000000000000..09d46b4bbe9223
--- /dev/null
+++ b/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCProxies.java
@@ -0,0 +1,44 @@
+package io.quarkus.jdbc.mysql.deployment;
+
+import java.io.Serializable;
+import java.sql.Statement;
+import java.util.ArrayList;
+import java.util.List;
+
+import com.mysql.cj.MysqlConnection;
+import com.mysql.cj.conf.PropertySet;
+import com.mysql.cj.jdbc.JdbcConnection;
+import com.mysql.cj.jdbc.JdbcPreparedStatement;
+import com.mysql.cj.jdbc.JdbcPropertySet;
+import com.mysql.cj.jdbc.JdbcStatement;
+import com.mysql.cj.jdbc.ha.LoadBalancedConnection;
+import com.mysql.cj.jdbc.ha.ReplicationConnection;
+import com.mysql.cj.jdbc.result.ResultSetInternalMethods;
+import com.mysql.cj.protocol.Resultset;
+
+import io.quarkus.deployment.annotations.BuildStep;
+import io.quarkus.deployment.builditem.nativeimage.NativeImageProxyDefinitionBuildItem;
+
+public final class MySQLJDBCProxies {
+
+    @BuildStep
+    List<NativeImageProxyDefinitionBuildItem> registerProxies() {
+        List<NativeImageProxyDefinitionBuildItem> proxies = new ArrayList<>();
+        proxies.add(new NativeImageProxyDefinitionBuildItem(JdbcConnection.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(MysqlConnection.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(Statement.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(AutoCloseable.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(JdbcStatement.class.getName()));
+        proxies.add(
+                new NativeImageProxyDefinitionBuildItem(JdbcPreparedStatement.class.getName(), JdbcStatement.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(JdbcPropertySet.class.getName(), PropertySet.class.getName(),
+                Serializable.class.getName()));
+        proxies.add(
+                new NativeImageProxyDefinitionBuildItem(Resultset.class.getName(), ResultSetInternalMethods.class.getName()));
+        proxies.add(new NativeImageProxyDefinitionBuildItem(LoadBalancedConnection.class.getName(),
+                JdbcConnection.class.getName()));
+        proxies.add(
+                new NativeImageProxyDefinitionBuildItem(ReplicationConnection.class.getName(), JdbcConnection.class.getName()));
+        return proxies;
+    }
+}
diff --git a/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCReflections.java b/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCReflections.java
index a85da95ca63071..d045030768b2c6 100644
--- a/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCReflections.java
+++ b/extensions/jdbc/jdbc-mysql/deployment/src/main/java/io/quarkus/jdbc/mysql/deployment/MySQLJDBCReflections.java
@@ -1,5 +1,6 @@
 package io.quarkus.jdbc.mysql.deployment;
 
+import com.mysql.cj.MysqlConnection;
 import com.mysql.cj.exceptions.AssertionFailedException;
 import com.mysql.cj.exceptions.CJCommunicationsException;
 import com.mysql.cj.exceptions.CJConnectionFeatureNotAvailableException;
@@ -26,6 +27,13 @@
 import com.mysql.cj.exceptions.UnableToConnectException;
 import com.mysql.cj.exceptions.UnsupportedConnectionStringException;
 import com.mysql.cj.exceptions.WrongArgumentException;
+import com.mysql.cj.jdbc.JdbcConnection;
+import com.mysql.cj.jdbc.MysqlDataSource;
+import com.mysql.cj.jdbc.MysqlXADataSource;
+import com.mysql.cj.jdbc.ha.NdbLoadBalanceExceptionChecker;
+import com.mysql.cj.jdbc.ha.ReplicationConnection;
+import com.mysql.cj.jdbc.ha.ReplicationMySQLConnection;
+import com.mysql.cj.jdbc.ha.StandardLoadBalanceExceptionChecker;
 import com.mysql.cj.protocol.AsyncSocketFactory;
 import com.mysql.cj.protocol.NamedPipeSocketFactory;
 import com.mysql.cj.protocol.SocksProxySocketFactory;
@@ -71,6 +79,13 @@ void registerSocketFactoryForReflection(BuildProducer<ReflectiveClassBuildItem>
         reflectiveClass.produce(new ReflectiveClassBuildItem(false, false, AsyncSocketFactory.class.getName()));
     }
 
+    @BuildStep
+    void registerLoadBalanceChecker(BuildProducer<ReflectiveClassBuildItem> reflectiveClass) {
+        reflectiveClass
+                .produce(new ReflectiveClassBuildItem(false, false, StandardLoadBalanceExceptionChecker.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(false, false, NdbLoadBalanceExceptionChecker.class.getName()));
+    }
+
     @BuildStep
     void registerExceptionsForReflection(BuildProducer<ReflectiveClassBuildItem> reflectiveClass) {
         reflectiveClass.produce(new ReflectiveClassBuildItem(false, false, CJCommunicationsException.class.getName()));
@@ -103,5 +118,12 @@ void registerExceptionsForReflection(BuildProducer<ReflectiveClassBuildItem> ref
         reflectiveClass
                 .produce(new ReflectiveClassBuildItem(false, false, UnsupportedConnectionStringException.class.getName()));
         reflectiveClass.produce(new ReflectiveClassBuildItem(false, false, WrongArgumentException.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, MysqlXADataSource.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, MysqlDataSource.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, MysqlConnection.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, ReplicationConnection.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, ReplicationMySQLConnection.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, JdbcConnection.class.getName()));
+        reflectiveClass.produce(new ReflectiveClassBuildItem(true, true, "com.mysql.cj.jdbc.MysqlXAException"));
     }
 }