diff --git a/modules/appnexusAstBidAdapter.js b/modules/appnexusAstBidAdapter.js
index 78b997b3ef45..c4e2686db15b 100644
--- a/modules/appnexusAstBidAdapter.js
+++ b/modules/appnexusAstBidAdapter.js
@@ -211,6 +211,7 @@ function newBid(serverBid, rtbBid) {
       image: nativeAd.main_img && nativeAd.main_img.url,
       icon: nativeAd.icon && nativeAd.icon.url,
       clickUrl: nativeAd.link.url,
+      clickTrackers: nativeAd.link.click_trackers,
       impressionTrackers: nativeAd.impression_trackers,
     };
   } else {
diff --git a/src/bidmanager.js b/src/bidmanager.js
index 800a0fe9579c..5d6a336b2a85 100644
--- a/src/bidmanager.js
+++ b/src/bidmanager.js
@@ -1,6 +1,6 @@
 import { uniques, flatten, adUnitsFilter, getBidderRequest } from './utils';
 import { getPriceBucketString } from './cpmBucketManager';
-import { NATIVE_KEYS, nativeBidIsValid } from './native';
+import { nativeBidIsValid, getNativeTargeting } from './native';
 import { isValidVideoBid } from './video';
 import { getCacheUrl, store } from './videoCache';
 import { Renderer } from 'src/Renderer';
@@ -275,13 +275,8 @@ function getKeyValueTargetingPairs(bidderCode, custBidObj) {
     custBidObj.sendStandardTargeting = defaultBidderSettingsMap[bidderCode].sendStandardTargeting;
   }
 
-  // set native key value targeting
   if (custBidObj['native']) {
-    Object.keys(custBidObj['native']).forEach(asset => {
-      const key = NATIVE_KEYS[asset];
-      const value = custBidObj['native'][asset];
-      if (key) { keyValues[key] = value; }
-    });
+    keyValues = Object.assign({}, keyValues, getNativeTargeting(custBidObj));
   }
 
   return keyValues;
diff --git a/src/native.js b/src/native.js
index 544258818ecc..c992cf9ad611 100644
--- a/src/native.js
+++ b/src/native.js
@@ -78,6 +78,11 @@ export function nativeBidIsValid(bid) {
     return false;
   }
 
+  // all native bid responses must define a landing page url
+  if (!deepAccess(bid, 'native.clickUrl')) {
+    return false;
+  }
+
   const requestedAssets = bidRequest.nativeParams;
   if (!requestedAssets) {
     return true;
@@ -94,14 +99,58 @@ export function nativeBidIsValid(bid) {
 }
 
 /*
- * Native responses may have impression trackers. This retrieves the
- * impression tracker urls for the given ad object and fires them.
+ * Native responses may have associated impression or click trackers.
+ * This retrieves the appropriate tracker urls for the given ad object and
+ * fires them. As a native creatives may be in a cross-origin frame, it may be
+ * necessary to invoke this function via postMessage. secureCreatives is
+ * configured to fire this function when it receives a `message` of 'Prebid Native'
+ * and an `adId` with the value of the `bid.adId`. When a message is posted with
+ * these parameters, impression trackers are fired. To fire click trackers, the
+ * message should contain an `action` set to 'click'.
+ *
+ * // Native creative template example usage
+ * <a href="%%CLICK_URL_UNESC%%%%PATTERN:hb_native_linkurl%%"
+ *    target="_blank"
+ *    onclick="fireTrackers('click')">
+ *    %%PATTERN:hb_native_title%%
+ * </a>
+ *
+ * <script>
+ *   function fireTrackers(action) {
+ *     var message = {message: 'Prebid Native', adId: '%%PATTERN:hb_adid%%'};
+ *     if (action === 'click') {message.action = 'click';} // fires click trackers
+ *     window.parent.postMessage(JSON.stringify(message), '*');
+ *   }
+ *   fireTrackers(); // fires impressions when creative is loaded
+ * </script>
  */
-export function fireNativeImpressions(adObject) {
-  const impressionTrackers =
-    adObject['native'] && adObject['native'].impressionTrackers;
+export function fireNativeTrackers(message, adObject) {
+  let trackers;
+
+  if (message.action === 'click') {
+    trackers = adObject['native'] && adObject['native'].clickTrackers;
+  } else {
+    trackers = adObject['native'] && adObject['native'].impressionTrackers;
+  }
 
-  (impressionTrackers || []).forEach(tracker => {
-    triggerPixel(tracker);
+  (trackers || []).forEach(triggerPixel);
+}
+
+/**
+ * Gets native targeting key-value paris
+ * @param {Object} bid
+ * @return {Object} targeting
+ */
+export function getNativeTargeting(bid) {
+  let keyValues = {};
+
+  Object.keys(bid['native']).forEach(asset => {
+    const key = NATIVE_KEYS[asset];
+    const value = bid['native'][asset];
+    if (key) {
+      keyValues[key] = value;
+    }
   });
+
+  return keyValues;
 }
diff --git a/src/secureCreatives.js b/src/secureCreatives.js
index 2402ba755f4a..efc1386fde39 100644
--- a/src/secureCreatives.js
+++ b/src/secureCreatives.js
@@ -4,7 +4,7 @@
  */
 
 import events from './events';
-import { fireNativeImpressions } from './native';
+import { fireNativeTrackers } from './native';
 import { EVENTS } from './constants';
 
 const BID_WON = EVENTS.BID_WON;
@@ -42,7 +42,7 @@ function receiveMessage(ev) {
     //   adId: '%%PATTERN:hb_adid%%'
     // }), '*');
     if (data.message === 'Prebid Native') {
-      fireNativeImpressions(adObject);
+      fireNativeTrackers(data, adObject);
       $$PREBID_GLOBAL$$._winningBids.push(adObject);
       events.emit(BID_WON, adObject);
     }
diff --git a/test/spec/bidmanager_spec.js b/test/spec/bidmanager_spec.js
index 5263741885a1..8434206c4bfd 100644
--- a/test/spec/bidmanager_spec.js
+++ b/test/spec/bidmanager_spec.js
@@ -590,7 +590,10 @@ describe('bidmanager.js', function () {
         {
           bidderCode: 'appnexusAst',
           mediaType: 'native',
-          native: {title: 'foo'}
+          native: {
+            title: 'foo',
+            clickUrl: 'example.link'
+          }
         }
       );
 
diff --git a/test/spec/native_spec.js b/test/spec/native_spec.js
new file mode 100644
index 000000000000..977575a4d19e
--- /dev/null
+++ b/test/spec/native_spec.js
@@ -0,0 +1,46 @@
+import { expect } from 'chai';
+import { fireNativeTrackers, getNativeTargeting } from 'src/native';
+const utils = require('src/utils');
+
+const bid = {
+  native: {
+    title: 'Native Creative',
+    body: 'Cool description great stuff',
+    cta: 'Do it',
+    sponsoredBy: 'AppNexus',
+    clickUrl: 'https://www.link.example',
+    clickTrackers: ['https://tracker.example'],
+    impressionTrackers: ['https://impression.example'],
+  }
+};
+
+describe('native.js', () => {
+  let triggerPixelStub;
+
+  beforeEach(() => {
+    triggerPixelStub = sinon.stub(utils, 'triggerPixel');
+  });
+
+  afterEach(() => {
+    utils.triggerPixel.restore();
+  });
+
+  it('gets native targeting keys', () => {
+    const targeting = getNativeTargeting(bid);
+    expect(targeting.hb_native_title).to.equal(bid.native.title);
+    expect(targeting.hb_native_body).to.equal(bid.native.body);
+    expect(targeting.hb_native_linkurl).to.equal(bid.native.clickUrl);
+  });
+
+  it('fires impression trackers', () => {
+    fireNativeTrackers({}, bid);
+    sinon.assert.calledOnce(triggerPixelStub);
+    sinon.assert.calledWith(triggerPixelStub, bid.native.impressionTrackers[0]);
+  });
+
+  it('fires click trackers', () => {
+    fireNativeTrackers({ action: 'click' }, bid);
+    sinon.assert.calledOnce(triggerPixelStub);
+    sinon.assert.calledWith(triggerPixelStub, bid.native.clickTrackers[0]);
+  });
+});