KCaS.channel.nml

<?xml version="1.0" encoding="ISO-8859-1"?>
<neuroml xmlns="http://www.neuroml.org/schema/neuroml2" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2beta4.xsd" id="NeuroML_ionChannel">

    <notes>NeuroML file containing a single ion channel</notes>

    <ionChannel id="KCaS" conductance="10pS" type="ionChannelHH" species="k">
        
        <notes>Ca++ activated K+ channel (AKA small/'SK' channel) description (Yuen and Durand 1991, modified by Aradi and Holmes 1999 (based on data from Beck 1997, Lattore 1989, Sah 1991 and Lancaster 1991))</notes>
        
        <gateHHrates id="q" instances="2">
            <q10Settings type="q10ExpTemp" q10Factor="3" experimentalTemp="34 degC"/>
            <forwardRate type="Bezaire_KCaS_alphaq"/>
            <reverseRate type="Bezaire_KCaS_betaq"/>
        </gateHHrates>
                            
    </ionChannel>
   
    
    <ComponentType name="Bezaire_KCaS_alphaq"
            extends="baseVoltageConcDepRate"
            description="forward rate to describe KCaS">
        
        <Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
        <Constant name="CONC_SCALE" dimension="concentration" value="1 mM"/>
        
        <Dynamics>
            <DerivedVariable name="ca_conc_i" dimension="none" value="caConc / CONC_SCALE"/>
            
            <DerivedVariable name="r" dimension="per_time" value="(12.5 * ca_conc_i * ca_conc_i) / TIME_SCALE" exposure="r"/>          
        </Dynamics>

    </ComponentType>
    
    <ComponentType name="Bezaire_KCaS_betaq"
            extends="baseVoltageDepRate"
            description="reverse rate to describe KCaS">
        
        <Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
        
        <Dynamics>         
            <DerivedVariable name="r" dimension="per_time" value="2.5e-4 / TIME_SCALE" exposure="r"/>          
        </Dynamics>
          
    </ComponentType>
    
</neuroml>