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research.html
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<!DOCTYPE html>
<html lang="en">
<head>
<title>Merrick's Research</title>
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<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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</head>
<body>
<!-- Nav bar start-->
<nav class="navbar navbar-expand-md navbar-dark fixed-top pt-3 mx-auto pr-5 pl-5" >
<a class="navbar-brand" href="/">Merrick Pierson Smela</a>
<div class="navbar-collapse collapse w-100 order-3 dual-collapse2">
<ul class="navbar-nav ml-auto pr-5">
<div class="collapse navbar-collapse" id="navbarsExampleDefault">
<ul class="navbar-nav mr-auto">
<li class="nav-item dropdown active">
<a class="nav-link dropdown-toggle" href="#" id="dropdown01" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">about me</a>
<div class="dropdown-menu" aria-labelledby="dropdown01">
<a class="dropdown-item" href="about.html">about me</a>
<a class="dropdown-item" href="photos.html">photo gallery</a>
<a class="dropdown-item" href="Merrick_CV.pdf">CV</a>
<a class="dropdown-item" href="contact.html">contact info</a>
</div>
</li>
<li class="nav-item dropdown active">
<a class="nav-link dropdown-toggle" href="#" id="dropdown01" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">research</a>
<div class="dropdown-menu" aria-labelledby="dropdown01">
<a class="dropdown-item" href="research.html">research interests</a>
<a class="dropdown-item" href="papers.html">published papers</a>
<a class="dropdown-item" href="presentation.html">presentations</a>
<a class="dropdown-item" href="people.html">collaborators</a>
</div>
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<input class="form-control mr-sm-2" type="search" placeholder="Search" aria-label="Search">
<button class="btn btn-outline-success my-2 my-sm-0" type="submit">Search</button>
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<main role="main" class="container">
<div class="pl-5 pr-5">
<br><br><br>
<div class="pt-1">
<h2>My Research Interests</h2>
</div>
<h5><i>In vitro</i> gametogenesis</h5>
<p class="text-justify">
The main goal of my scientific career is the reliable, safe, and inexpensive production of human eggs and sperm in cell culture.
This would solve nearly all infertility, and also enable important advances in the study of developmental biology.
Working towards this goal, I have developed methods for producing ovarian cell types, such as granulosa cells and oogonia, from human induced pluripotent stem cells. (See the <a href="papers.html">Publications</a> section for more detailed information.)
</p>
<h5>Regulation of meiosis</h5>
<p class="text-justify">
Meiosis is the central process of sexual reproduction, and is a key step for gamete formation.
Developing a system for inducing meiosis in mammalian cells on demand would benefit <i>in vitro</i> gametogenesis and might also allow parallelizing gene editing by conducting "genetic crosses" <i>in vitro</i>.
I am researching the regulation of meiosis in order to achieve this goal.
</p>
<h5>Whole genome sequencing for iPSC quality control</h5>
<p class="text-justify">
I regularly generate edited stem cell lines as part of my research. Current methods for quality control (based on karyotyping and targeted Sanger sequencing) are laborious, expensive, and may miss some abnormalities.
Whole-genome sequencing (WGS) offers a better alternative. Working with my undergrad mentee Valerio Pepe, I am developing <a href="https://github.com/mpiersonsmela/SeqVerify">SeqVerify</a>, a computational pipeline to take WGS data and perform various quality control checks.
</p>
<h5>Other interests</h5>
<p class="text-justify">
T-box riboswitches, ribozymes, gene regulatory networks, epigenetics, organic chemistry, pandemic prevention . . . the list goes on and on.
</p>
</div>
<br>
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