diff --git a/packages/material-ui-lab/src/TreeItem/TreeItem.js b/packages/material-ui-lab/src/TreeItem/TreeItem.js
index ae7be28aeadca7..2066db063642a7 100644
--- a/packages/material-ui-lab/src/TreeItem/TreeItem.js
+++ b/packages/material-ui-lab/src/TreeItem/TreeItem.js
@@ -150,7 +150,7 @@ const TreeItem = React.forwardRef(function TreeItem(props, ref) {
     let flag = false;
     const key = event.key;
 
-    if (event.altKey || event.ctrlKey || event.metaKey) {
+    if (event.altKey || event.ctrlKey || event.metaKey || event.currentTarget !== event.target) {
       return;
     }
     if (event.shift) {