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Add gemBS option #387

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seynard opened this issue Mar 6, 2024 · 4 comments
Closed

Add gemBS option #387

seynard opened this issue Mar 6, 2024 · 4 comments
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enhancement New feature or request

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@seynard
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seynard commented Mar 6, 2024

Description of feature

Hi, I really like using the nf-core MethylSeq but recently we've been wanting to test gemBS to analyse our RRBS data. We are wondering if this tool could be added to the pipeline as an alternative to Bismark or BWAMeth?
Thanks in advance for your help.

@seynard seynard added the enhancement New feature or request label Mar 6, 2024
@sateeshperi
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hi @seynard could you provide any links to gemBS and why you think it will be a good addition to methylseq ?

@seynard
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seynard commented Dec 14, 2024

Hi @sateeshperi, actually I'm not sure gemBS would be the best addition, maybe BISCUIT could also be one, we are working on finding the best tool for our purpose but the idea would be to have, in parallel of the methylation calling also the variant calling from bisulfite sequencing data and as these tools do both they could be nice additions to the general pipeline. We are in the process of testing them and seeing if they answer well our purpose.

@sateeshperi
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sateeshperi commented Dec 14, 2024

I have biscuit on my roadmap. Let me know if you want to work together to integrate it. reach out on slack. thank you

@seynard
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seynard commented Dec 16, 2024

Dear Sateesh, super that it's already on your road map, we also found this fork that have already developed it https://github.com/ekushele/methylseq but a colleague (Rémi Séraphin) and I would definitely be happy to contribute to that so let us know how we can arrange ourselves to help out :)

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