diff --git a/lib/upload.js b/lib/upload.js
index 83dfa35b..c3857850 100644
--- a/lib/upload.js
+++ b/lib/upload.js
@@ -615,6 +615,11 @@ class BaseUpload {
         if (status === 423) {
           this._emitHttpError(req, res, 'tus: upload is currently locked; retry later')
           return
+        } else if (inStatusCategory(status, 500)) {
+          // Run retry logic if the server has an error, e.g. 502 Bad Gateway when
+          // proxied server is temporarily down. See issue #579.
+          this._emitHttpError(req, res, 'tus: resuming upload resulted in HTTP 500 category error')
+          return
         }
 
         if (inStatusCategory(status, 400)) {