diff --git a/changelogs/fragments/6294-fix-one_vm-instantiation.yml b/changelogs/fragments/6294-fix-one_vm-instantiation.yml
new file mode 100644
index 00000000000..dbe98f1ef08
--- /dev/null
+++ b/changelogs/fragments/6294-fix-one_vm-instantiation.yml
@@ -0,0 +1,2 @@
+bugfixes:
+  - one_vm - fix syntax error when creating VMs with a more complex template (https://github.com/ansible-collections/community.general/issues/6225)
diff --git a/plugins/module_utils/opennebula.py b/plugins/module_utils/opennebula.py
index 0fe649ba5c0..0c6228cc528 100644
--- a/plugins/module_utils/opennebula.py
+++ b/plugins/module_utils/opennebula.py
@@ -52,6 +52,9 @@ def recurse(to_render):
                 for item in value:
                     yield '{0:}=[{1:}]'.format(key, ','.join(recurse(item)))
                 continue
+            if isinstance(value, str):
+                yield '{0:}="{1:}"'.format(key, value.replace('"', '\\"'))
+                continue
             yield '{0:}="{1:}"'.format(key, value)
     return '\n'.join(recurse(to_render))
 
diff --git a/tests/unit/plugins/module_utils/test_opennebula.py b/tests/unit/plugins/module_utils/test_opennebula.py
index 550d403711a..1fc26eb1231 100644
--- a/tests/unit/plugins/module_utils/test_opennebula.py
+++ b/tests/unit/plugins/module_utils/test_opennebula.py
@@ -75,6 +75,14 @@
             NIC=[NAME="NIC1",NETWORK_ID="1"]
         ''').strip()
     ),
+    (
+        {
+            'SCHED_REQUIREMENTS': 'CLUSTER_ID="100"',
+        },
+        textwrap.dedent('''
+            SCHED_REQUIREMENTS="CLUSTER_ID=\\"100\\""
+        ''').strip()
+    )
 ]