diff --git a/doc/api/errors.md b/doc/api/errors.md
index 3923780defa1e7..49834414decffe 100644
--- a/doc/api/errors.md
+++ b/doc/api/errors.md
@@ -586,6 +586,14 @@ found [here][online].
 <a id="nodejs-error-codes"></a>
 ## Node.js Error Codes
 
+<a id="ERR_AMBIGUOUS_ARGUMENT"></a>
+### ERR_AMBIGUOUS_ARGUMENT
+
+This is triggered by the `assert` module in case e.g.,
+`assert.throws(fn, message)` is used in a way that the message is the thrown
+error message. This is ambiguous because the message is not verifying the error
+message and will only be thrown in case no error is thrown.
+
 <a id="ERR_ARG_NOT_ITERABLE"></a>
 ### ERR_ARG_NOT_ITERABLE
 
diff --git a/lib/assert.js b/lib/assert.js
index 385ec332a6f999..0a505d553a405c 100644
--- a/lib/assert.js
+++ b/lib/assert.js
@@ -29,6 +29,7 @@ const {
   AssertionError,
   errorCache,
   codes: {
+    ERR_AMBIGUOUS_ARGUMENT,
     ERR_INVALID_ARG_TYPE
   }
 } = require('internal/errors');
@@ -470,6 +471,19 @@ function expectsError(stackStartFn, actual, error, message) {
                                      ['Object', 'Error', 'Function', 'RegExp'],
                                      error);
     }
+    if (typeof actual === 'object' && actual !== null) {
+      if (actual.message === error) {
+        throw new ERR_AMBIGUOUS_ARGUMENT(
+          'error/message',
+          `The error message "${actual.message}" is identical to the message.`
+        );
+      }
+    } else if (actual === error) {
+      throw new ERR_AMBIGUOUS_ARGUMENT(
+        'error/message',
+        `The error "${actual}" is identical to the message.`
+      );
+    }
     message = error;
     error = null;
   }
diff --git a/lib/internal/errors.js b/lib/internal/errors.js
index b190ae32bf6c8f..c8be91796ec249 100644
--- a/lib/internal/errors.js
+++ b/lib/internal/errors.js
@@ -640,6 +640,7 @@ module.exports = exports = {
 //
 // Note: Node.js specific errors must begin with the prefix ERR_
 
+E('ERR_AMBIGUOUS_ARGUMENT', 'The "%s" argument is ambiguous. %s', TypeError);
 E('ERR_ARG_NOT_ITERABLE', '%s must be iterable', TypeError);
 E('ERR_ASSERTION', '%s', Error);
 E('ERR_ASYNC_CALLBACK', '%s must be a function', TypeError);
diff --git a/test/parallel/test-assert.js b/test/parallel/test-assert.js
index 4115167d4b48fd..c06155160495bc 100644
--- a/test/parallel/test-assert.js
+++ b/test/parallel/test-assert.js
@@ -836,3 +836,32 @@ common.expectsError(
     }
   );
 }
+
+assert.throws(
+  () => a.throws(
+    // eslint-disable-next-line no-throw-literal
+    () => { throw 'foo'; },
+    'foo'
+  ),
+  {
+    code: 'ERR_AMBIGUOUS_ARGUMENT',
+    message: 'The "error/message" argument is ambiguous. ' +
+             'The error "foo" is identical to the message.'
+  }
+);
+
+assert.throws(
+  () => a.throws(
+    () => { throw new TypeError('foo'); },
+    'foo'
+  ),
+  {
+    code: 'ERR_AMBIGUOUS_ARGUMENT',
+    message: 'The "error/message" argument is ambiguous. ' +
+             'The error message "foo" is identical to the message.'
+  }
+);
+
+// Should not throw.
+// eslint-disable-next-line no-restricted-syntax, no-throw-literal
+assert.throws(() => { throw null; }, 'foo');