diff --git a/README.md b/README.md index 13419e9..38569da 100644 --- a/README.md +++ b/README.md @@ -1,7 +1,7 @@ [![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.8122410.svg)](https://doi.org/10.5281/zenodo.8122410) # Overview -This repository contains all of the simulation and analysis code for the manuscript ["Transient and delay chemical master equations"](https://www.biorxiv.org/content/10.1101/2022.10.17.512599v1), a discussion of the prospects for solving and applying delay master equations in the context of RNA sequencing. In the first part of the report, we numerically solve a fairly generic set of systems with gene switching and mixed Markovian/non-Markovian downstream processing. In the second part, we analytically solve a set of bursty two-species systems with delayed steps, fit single-cell and single-nucleus RNA sequencing data, and compare the fits to draw conclusions about model suitability and identifiability. +This repository contains all of the simulation and analysis code for the manuscript "Assessing Markovian and delay models for single-nucleus RNA sequencing," a discussion of the prospects for solving and applying delay master equations in the context of RNA sequencing. In the first part of the report, we numerically solve a fairly generic set of systems with gene switching and mixed Markovian/non-Markovian downstream processing. In the second part, we analytically solve a set of bursty two-species systems with delayed steps, fit single-cell and single-nucleus RNA sequencing data, and compare the fits to draw conclusions about model suitability and identifiability. # Repository contents