diff --git a/src/python/pants/backend/native/subsystems/native_toolchain.py b/src/python/pants/backend/native/subsystems/native_toolchain.py
index b1aa51068820..00c0425d6b6f 100644
--- a/src/python/pants/backend/native/subsystems/native_toolchain.py
+++ b/src/python/pants/backend/native/subsystems/native_toolchain.py
@@ -324,7 +324,7 @@ def select_llvm_c_toolchain(platform, native_toolchain):
       exe_filename=provided_clang.exe_filename,
       runtime_library_dirs=(provided_clang.runtime_library_dirs + xcode_clang.runtime_library_dirs),
       include_dirs=(provided_clang.include_dirs + xcode_clang.include_dirs),
-      extra_args=(llvm_c_compiler_args + xcode_clang.extra_args))
+      extra_args=(llvm_c_compiler_args + xcode_clang.extra_args + ['-nobuiltininc']))
   else:
     gcc_install = yield Get(GCCInstallLocationForLLVM, GCC, native_toolchain._gcc)
     provided_gcc = yield Get(CCompiler, GCC, native_toolchain._gcc)
@@ -375,7 +375,7 @@ def select_llvm_cpp_toolchain(platform, native_toolchain):
       include_dirs=(provided_clangpp.include_dirs + xcode_clang.include_dirs),
       # On OSX, this uses the libc++ (LLVM) C++ standard library implementation. This is
       # feature-complete for OSX, but not for Linux (see https://libcxx.llvm.org/ for more info).
-      extra_args=(llvm_cpp_compiler_args + xcode_clang.extra_args))
+      extra_args=(llvm_cpp_compiler_args + xcode_clang.extra_args + ['-nobuiltininc']))
     linking_library_dirs = []
     linker_extra_args = []
   else:
diff --git a/src/python/pants/backend/python/subsystems/python_native_code.py b/src/python/pants/backend/python/subsystems/python_native_code.py
index c29857b4b319..6bb8eccbe15b 100644
--- a/src/python/pants/backend/python/subsystems/python_native_code.py
+++ b/src/python/pants/backend/python/subsystems/python_native_code.py
@@ -252,8 +252,8 @@ def as_environment(self):
       # FIXME: distutils will use CFLAGS to populate LDFLAGS and CXXFLAGS as well if specified --
       # this probably requires a workaround as discused in #5661.
       ret['CFLAGS'] = safe_shlex_join(plat.resolve_platform_specific({
-        'darwin': lambda: [MIN_OSX_VERSION_ARG],
-        'linux': lambda: [],
+        'darwin': lambda: [MIN_OSX_VERSION_ARG, '-nobuiltininc', '-nostdinc', '-nostdinc++'],
+        'linux': lambda: ['-nostdinc', '-nostdinc++'],
       }))
       # ret['CFLAGS'] = safe_shlex_join(c_compiler.extra_args)
       # ret['CXXFLAGS'] = safe_shlex_join(cpp_compiler.extra_args)