diff --git a/session/session.go b/session/session.go
index 96d2851653a98..ca9d361893faa 100644
--- a/session/session.go
+++ b/session/session.go
@@ -1219,22 +1219,32 @@ func (s *session) isTxnRetryableError(err error) bool {
 	return kv.IsTxnRetryableError(err) || domain.ErrInfoSchemaChanged.Equal(err)
 }
 
+func isEndTxnStmt(stmt ast.StmtNode, vars *variable.SessionVars) (bool, error) {
+	switch n := stmt.(type) {
+	case *ast.RollbackStmt, *ast.CommitStmt:
+		return true, nil
+	case *ast.ExecuteStmt:
+		ps, err := plannercore.GetPreparedStmt(n, vars)
+		if err != nil {
+			return false, err
+		}
+		return isEndTxnStmt(ps.PreparedAst.Stmt, vars)
+	}
+	return false, nil
+}
+
 func (s *session) checkTxnAborted(stmt sqlexec.Statement) error {
-	var err error
-	if atomic.LoadUint32(&s.GetSessionVars().TxnCtx.LockExpire) > 0 {
-		err = kv.ErrLockExpire
-	} else {
+	if atomic.LoadUint32(&s.GetSessionVars().TxnCtx.LockExpire) == 0 {
 		return nil
 	}
 	// If the transaction is aborted, the following statements do not need to execute, except `commit` and `rollback`,
 	// because they are used to finish the aborted transaction.
-	if _, ok := stmt.(*executor.ExecStmt).StmtNode.(*ast.CommitStmt); ok {
-		return nil
-	}
-	if _, ok := stmt.(*executor.ExecStmt).StmtNode.(*ast.RollbackStmt); ok {
+	if ok, err := isEndTxnStmt(stmt.(*executor.ExecStmt).StmtNode, s.sessionVars); err == nil && ok {
 		return nil
+	} else if err != nil {
+		return err
 	}
-	return err
+	return kv.ErrLockExpire
 }
 
 func (s *session) retry(ctx context.Context, maxCnt uint) (err error) {
diff --git a/tests/realtikvtest/pessimistictest/BUILD.bazel b/tests/realtikvtest/pessimistictest/BUILD.bazel
index d728cd27e686a..86dfdb4cd2dd3 100644
--- a/tests/realtikvtest/pessimistictest/BUILD.bazel
+++ b/tests/realtikvtest/pessimistictest/BUILD.bazel
@@ -35,6 +35,7 @@ go_test(
         "@com_github_pingcap_errors//:errors",
         "@com_github_pingcap_failpoint//:failpoint",
         "@com_github_stretchr_testify//require",
+        "@com_github_tikv_client_go_v2//config",
         "@com_github_tikv_client_go_v2//oracle",
         "@com_github_tikv_client_go_v2//testutils",
         "@com_github_tikv_client_go_v2//tikv",
diff --git a/tests/realtikvtest/pessimistictest/pessimistic_test.go b/tests/realtikvtest/pessimistictest/pessimistic_test.go
index 0db67fefc9fff..e322a3d803286 100644
--- a/tests/realtikvtest/pessimistictest/pessimistic_test.go
+++ b/tests/realtikvtest/pessimistictest/pessimistic_test.go
@@ -50,6 +50,7 @@ import (
 	"github.com/pingcap/tidb/util/codec"
 	"github.com/pingcap/tidb/util/deadlockhistory"
 	"github.com/stretchr/testify/require"
+	tikvcfg "github.com/tikv/client-go/v2/config"
 	"github.com/tikv/client-go/v2/oracle"
 	"github.com/tikv/client-go/v2/testutils"
 	"github.com/tikv/client-go/v2/tikv"
@@ -3793,3 +3794,37 @@ func TestIssue42937(t *testing.T) {
 		"5 11",
 	))
 }
+
+func TestEndTxnOnLockExpire(t *testing.T) {
+	store := testkit.CreateMockStore(t)
+	tk := testkit.NewTestKit(t, store)
+	tk.MustExec("use test")
+	tk.MustExec("create table t(a int, b int)")
+	tk.MustExec("prepare ps_commit from 'commit'")
+	tk.MustExec("prepare ps_rollback from 'rollback'")
+
+	defer setLockTTL(300).restore()
+	defer tikvcfg.UpdateGlobal(func(conf *tikvcfg.Config) {
+		conf.MaxTxnTTL = 500
+	})()
+
+	for _, tt := range []struct {
+		name      string
+		endTxnSQL string
+	}{
+		{"CommitTxt", "commit"},
+		{"CommitBin", "execute ps_commit"},
+		{"RollbackTxt", "rollback"},
+		{"RollbackBin", "execute ps_rollback"},
+	} {
+		t.Run(tt.name, func(t *testing.T) {
+			tk.Exec("delete from t")
+			tk.Exec("insert into t values (1, 1)")
+			tk.Exec("begin pessimistic")
+			tk.Exec("update t set b = 10 where a = 1")
+			time.Sleep(time.Second)
+			tk.MustContainErrMsg("select * from t", "TTL manager has timed out")
+			tk.MustExec(tt.endTxnSQL)
+		})
+	}
+}