diff --git a/pkg/ddl/ddl.go b/pkg/ddl/ddl.go
index 2b57cde0828c2..912eaa271e4a5 100644
--- a/pkg/ddl/ddl.go
+++ b/pkg/ddl/ddl.go
@@ -1010,7 +1010,9 @@ func (d *ddl) close() {
 	// when run with real-tikv, the lifecycle of ownerManager is managed by globalOwnerManager,
 	// when run with uni-store BreakCampaignLoop is same as Close.
 	// hope we can unify it after refactor to let some components only start once.
-	d.ownerManager.BreakCampaignLoop()
+	if d.ownerManager != nil {
+		d.ownerManager.BreakCampaignLoop()
+	}
 	d.schemaVerSyncer.Close()
 
 	// d.delRangeMgr using sessions from d.sessPool.
diff --git a/pkg/domain/domain.go b/pkg/domain/domain.go
index 4b14d1ae8b17a..66a65f49b6a4b 100644
--- a/pkg/domain/domain.go
+++ b/pkg/domain/domain.go
@@ -275,6 +275,11 @@ func (do *Domain) EtcdClient() *clientv3.Client {
 	return do.etcdClient
 }
 
+// UnprefixedEtcdCli export for test.
+func (do *Domain) UnprefixedEtcdCli() *clientv3.Client {
+	return do.unprefixedEtcdCli
+}
+
 // loadInfoSchema loads infoschema at startTS.
 // It returns:
 // 1. the needed infoschema
@@ -1280,6 +1285,11 @@ const resourceIdleTimeout = 3 * time.Minute // resources in the ResourcePool wil
 
 // NewDomain creates a new domain. Should not create multiple domains for the same store.
 func NewDomain(store kv.Storage, schemaLease time.Duration, statsLease time.Duration, dumpFileGcLease time.Duration, factory pools.Factory) *Domain {
+	return NewDomainWithEtcdClient(store, schemaLease, statsLease, dumpFileGcLease, factory, nil)
+}
+
+// NewDomainWithEtcdClient creates a new domain with etcd client. Should not create multiple domains for the same store.
+func NewDomainWithEtcdClient(store kv.Storage, schemaLease time.Duration, statsLease time.Duration, dumpFileGcLease time.Duration, factory pools.Factory, etcdClient *clientv3.Client) *Domain {
 	intest.Assert(schemaLease > 0, "schema lease should be a positive duration")
 	capacity := 200 // capacity of the sysSessionPool size
 	do := &Domain{
@@ -1324,6 +1334,7 @@ func NewDomain(store kv.Storage, schemaLease time.Duration, statsLease time.Dura
 	do.sysProcesses = SysProcesses{mu: &sync.RWMutex{}, procMap: make(map[uint64]sysproctrack.TrackProc)}
 	do.initDomainSysVars()
 	do.expiredTimeStamp4PC.expiredTimeStamp = types.NewTime(types.ZeroCoreTime, mysql.TypeTimestamp, types.DefaultFsp)
+	do.etcdClient = etcdClient
 	return do
 }
 
diff --git a/pkg/session/BUILD.bazel b/pkg/session/BUILD.bazel
index cb05016d148c1..f2da24851b1d8 100644
--- a/pkg/session/BUILD.bazel
+++ b/pkg/session/BUILD.bazel
@@ -131,6 +131,7 @@ go_library(
         "@com_github_tikv_client_go_v2//oracle",
         "@com_github_tikv_client_go_v2//tikv",
         "@com_github_tikv_client_go_v2//util",
+        "@io_etcd_go_etcd_client_v3//:client",
         "@io_etcd_go_etcd_client_v3//concurrency",
         "@org_uber_go_atomic//:atomic",
         "@org_uber_go_zap//:zap",
@@ -161,6 +162,7 @@ go_test(
         "//pkg/executor",
         "//pkg/expression",
         "//pkg/expression/sessionexpr",
+        "//pkg/keyspace",
         "//pkg/kv",
         "//pkg/meta",
         "//pkg/parser",
@@ -181,9 +183,11 @@ go_test(
         "//pkg/util/logutil",
         "//pkg/util/sqlexec",
         "@com_github_pingcap_failpoint//:failpoint",
+        "@com_github_pingcap_kvproto//pkg/keyspacepb",
         "@com_github_pingcap_log//:log",
         "@com_github_stretchr_testify//require",
         "@com_github_tikv_client_go_v2//tikv",
+        "@io_etcd_go_etcd_tests_v3//integration",
         "@org_uber_go_atomic//:atomic",  #keep
         "@org_uber_go_goleak//:goleak",
         "@org_uber_go_zap//:zap",
diff --git a/pkg/session/bootstrap_test.go b/pkg/session/bootstrap_test.go
index d4d4f75d4f882..9ff0d449be6ab 100644
--- a/pkg/session/bootstrap_test.go
+++ b/pkg/session/bootstrap_test.go
@@ -16,6 +16,7 @@ package session
 
 import (
 	"context"
+	"crypto/tls"
 	"fmt"
 	"sort"
 	"strings"
@@ -23,11 +24,14 @@ import (
 	"time"
 
 	"github.com/pingcap/failpoint"
+	"github.com/pingcap/kvproto/pkg/keyspacepb"
 	"github.com/pingcap/log"
 	"github.com/pingcap/tidb/pkg/bindinfo"
 	"github.com/pingcap/tidb/pkg/ddl"
 	"github.com/pingcap/tidb/pkg/domain"
 	"github.com/pingcap/tidb/pkg/expression/sessionexpr"
+	"github.com/pingcap/tidb/pkg/keyspace"
+	"github.com/pingcap/tidb/pkg/kv"
 	"github.com/pingcap/tidb/pkg/meta"
 	"github.com/pingcap/tidb/pkg/parser"
 	"github.com/pingcap/tidb/pkg/parser/auth"
@@ -38,6 +42,7 @@ import (
 	"github.com/pingcap/tidb/pkg/store/mockstore"
 	"github.com/pingcap/tidb/pkg/table/tblsession"
 	"github.com/stretchr/testify/require"
+	"go.etcd.io/etcd/tests/v3/integration"
 	"go.uber.org/zap"
 	"go.uber.org/zap/zapcore"
 )
@@ -2524,3 +2529,88 @@ func TestIndexJoinMultiPatternByUpgrade650To840(t *testing.T) {
 	require.Equal(t, 1, row.Len())
 	require.Equal(t, int64(0), row.GetInt64(0))
 }
+
+func TestKeyspaceEtcdNamespace(t *testing.T) {
+	keyspaceMeta := keyspacepb.KeyspaceMeta{}
+	keyspaceMeta.Id = 2
+	keyspaceMeta.Name = "test_ks_name2"
+	makeStore(t, &keyspaceMeta, true)
+}
+
+func TestNullKeyspaceEtcdNamespace(t *testing.T) {
+	makeStore(t, nil, false)
+}
+
+func makeStore(t *testing.T, keyspaceMeta *keyspacepb.KeyspaceMeta, isHasPrefix bool) {
+	integration.BeforeTestExternal(t)
+	var store kv.Storage
+	var err error
+	if keyspaceMeta != nil {
+		store, err = mockstore.NewMockStore(
+			mockstore.WithKeyspaceMeta(keyspaceMeta),
+			mockstore.WithStoreType(mockstore.EmbedUnistore),
+		)
+	} else {
+		store, err = mockstore.NewMockStore(mockstore.WithStoreType(mockstore.EmbedUnistore))
+	}
+	require.NoError(t, err)
+	defer func() {
+		require.NoError(t, store.Close())
+	}()
+
+	cluster := integration.NewClusterV3(t, &integration.ClusterConfig{Size: 1})
+	defer cluster.Terminate(t)
+
+	// Build a mockEtcdBackend.
+	mockStore := &mockEtcdBackend{
+		Storage: store,
+		pdAddrs: []string{cluster.Members[0].GRPCURL()}}
+	etcdClient := cluster.RandClient()
+
+	require.NoError(t, err)
+	dom, err := domap.getWithEtcdClient(mockStore, etcdClient)
+	require.NoError(t, err)
+	defer dom.Close()
+
+	checkETCDNameSpace(t, dom, isHasPrefix)
+}
+
+func checkETCDNameSpace(t *testing.T, dom *domain.Domain, isHasPrefix bool) {
+	namespacePrefix := keyspace.MakeKeyspaceEtcdNamespace(dom.Store().GetCodec())
+	testKeyWithoutPrefix := "/testkey"
+	testVal := "test"
+	var expectTestKey string
+	if isHasPrefix {
+		expectTestKey = namespacePrefix + testKeyWithoutPrefix
+	} else {
+		expectTestKey = testKeyWithoutPrefix
+	}
+
+	// Put key value into etcd.
+	_, err := dom.EtcdClient().Put(context.Background(), testKeyWithoutPrefix, testVal)
+	require.NoError(t, err)
+
+	// Use expectTestKey to get the key from etcd.
+	getResp, err := dom.UnprefixedEtcdCli().Get(context.Background(), expectTestKey)
+	require.NoError(t, err)
+	require.Equal(t, len(getResp.Kvs), 1)
+
+	if isHasPrefix {
+		getResp, err = dom.UnprefixedEtcdCli().Get(context.Background(), testKeyWithoutPrefix)
+		require.NoError(t, err)
+		require.Equal(t, 0, len(getResp.Kvs))
+	}
+}
+
+type mockEtcdBackend struct {
+	kv.Storage
+	pdAddrs []string
+}
+
+func (mebd *mockEtcdBackend) EtcdAddrs() ([]string, error) {
+	return mebd.pdAddrs, nil
+}
+
+func (mebd *mockEtcdBackend) TLSConfig() *tls.Config { return nil }
+
+func (mebd *mockEtcdBackend) StartGCWorker() error { return nil }
diff --git a/pkg/session/tidb.go b/pkg/session/tidb.go
index 5b095e3a76587..eb0c98a9fa638 100644
--- a/pkg/session/tidb.go
+++ b/pkg/session/tidb.go
@@ -47,6 +47,7 @@ import (
 	"github.com/pingcap/tidb/pkg/util/logutil"
 	"github.com/pingcap/tidb/pkg/util/sqlexec"
 	"github.com/pingcap/tidb/pkg/util/syncutil"
+	clientv3 "go.etcd.io/etcd/client/v3"
 	"go.uber.org/zap"
 )
 
@@ -62,6 +63,10 @@ type domainMap struct {
 // TODO decouple domain create from it, it's more clear to create domain explicitly
 // before any usage of it.
 func (dm *domainMap) Get(store kv.Storage) (d *domain.Domain, err error) {
+	return dm.getWithEtcdClient(store, nil)
+}
+
+func (dm *domainMap) getWithEtcdClient(store kv.Storage, etcdClient *clientv3.Client) (d *domain.Domain, err error) {
 	dm.mu.Lock()
 	defer dm.mu.Unlock()
 
@@ -90,7 +95,7 @@ func (dm *domainMap) Get(store kv.Storage) (d *domain.Domain, err error) {
 			zap.Stringer("stats lease", statisticLease))
 		factory := createSessionFunc(store)
 		sysFactory := createSessionWithDomainFunc(store)
-		d = domain.NewDomain(store, ddlLease, statisticLease, planReplayerGCLease, factory)
+		d = domain.NewDomainWithEtcdClient(store, ddlLease, statisticLease, planReplayerGCLease, factory, etcdClient)
 
 		var ddlInjector func(ddl.DDL, ddl.Executor, *infoschema.InfoCache) *schematracker.Checker
 		if injector, ok := store.(schematracker.StorageDDLInjector); ok {
diff --git a/pkg/store/mockstore/mockcopr/executor_test.go b/pkg/store/mockstore/mockcopr/executor_test.go
index 75a9f4a5abff9..211e67d0fd024 100644
--- a/pkg/store/mockstore/mockcopr/executor_test.go
+++ b/pkg/store/mockstore/mockcopr/executor_test.go
@@ -52,7 +52,7 @@ func TestResolvedLargeTxnLocks(t *testing.T) {
 	tikvStore, err := tikv.NewTestTiKVStore(rpcClient, pdClient, nil, nil, 0)
 	require.NoError(t, err)
 
-	store, err := mockstorage.NewMockStorage(tikvStore)
+	store, err := mockstorage.NewMockStorage(tikvStore, nil)
 	require.NoError(t, err)
 	defer func() {
 		require.NoError(t, store.Close())
diff --git a/pkg/store/mockstore/mockstorage/storage.go b/pkg/store/mockstore/mockstorage/storage.go
index dc20704493b80..ca70712d8e69c 100644
--- a/pkg/store/mockstore/mockstorage/storage.go
+++ b/pkg/store/mockstore/mockstorage/storage.go
@@ -43,16 +43,17 @@ type mockStorage struct {
 }
 
 // NewMockStorage wraps tikv.KVStore as kv.Storage.
-func NewMockStorage(tikvStore *tikv.KVStore) (kv.Storage, error) {
+func NewMockStorage(tikvStore *tikv.KVStore, keyspaceMeta *keyspacepb.KeyspaceMeta) (kv.Storage, error) {
 	coprConfig := config.DefaultConfig().TiKVClient.CoprCache
 	coprStore, err := copr.NewStore(tikvStore, &coprConfig)
 	if err != nil {
 		return nil, err
 	}
 	return &mockStorage{
-		KVStore:  tikvStore,
-		Store:    coprStore,
-		memCache: kv.NewCacheDB(),
+		KVStore:      tikvStore,
+		Store:        coprStore,
+		memCache:     kv.NewCacheDB(),
+		keyspaceMeta: keyspaceMeta,
 	}, nil
 }
 
diff --git a/pkg/store/mockstore/tikv.go b/pkg/store/mockstore/tikv.go
index eb56eae38f0a4..ff8e5a12dd7fb 100644
--- a/pkg/store/mockstore/tikv.go
+++ b/pkg/store/mockstore/tikv.go
@@ -39,5 +39,5 @@ func newMockTikvStore(opt *mockOptions) (kv.Storage, error) {
 	if err != nil {
 		return nil, err
 	}
-	return mockstorage.NewMockStorage(kvstore)
+	return mockstorage.NewMockStorage(kvstore, opt.keyspaceMeta)
 }
diff --git a/pkg/store/mockstore/unistore.go b/pkg/store/mockstore/unistore.go
index 2b4948fb2cdfb..bf68f4417b865 100644
--- a/pkg/store/mockstore/unistore.go
+++ b/pkg/store/mockstore/unistore.go
@@ -50,5 +50,5 @@ func newUnistore(opts *mockOptions) (kv.Storage, error) {
 		}
 	}
 
-	return mockstorage.NewMockStorage(kvstore)
+	return mockstorage.NewMockStorage(kvstore, opts.keyspaceMeta)
 }