diff --git a/.github/native-tests.json b/.github/native-tests.json
index c68511a1e63c6..84c6f6d06d7eb 100644
--- a/.github/native-tests.json
+++ b/.github/native-tests.json
@@ -45,7 +45,7 @@
         {
             "category": "Data7",
             "timeout": 85,
-            "test-modules": "reactive-oracle-client, reactive-mysql-client, reactive-db2-client, hibernate-reactive-db2, hibernate-reactive-mysql, hibernate-reactive-mysql-agroal, hibernate-reactive-panache, hibernate-reactive-panache-kotlin",
+            "test-modules": "reactive-oracle-client, reactive-mysql-client, reactive-db2-client, hibernate-reactive-db2, hibernate-reactive-mysql, hibernate-reactive-mysql-agroal-flyway, hibernate-reactive-panache, hibernate-reactive-panache-kotlin",
             "os-name": "ubuntu-latest"
         },
         {
diff --git a/docs/src/main/asciidoc/hibernate-reactive.adoc b/docs/src/main/asciidoc/hibernate-reactive.adoc
index d6ee6d9e0fd57..9a23bda4676b3 100644
--- a/docs/src/main/asciidoc/hibernate-reactive.adoc
+++ b/docs/src/main/asciidoc/hibernate-reactive.adoc
@@ -301,12 +301,6 @@ it's not possible to configure multiple persistence units,
 or even a single named persistence unit.
 * This extension cannot be used at the same time as Hibernate ORM.
 See https://github.com/quarkusio/quarkus/issues/13425.
-* This extension cannot be used at the same time as JDBC/Agroal.
-See https://github.com/quarkusio/quarkus/issues/33380.
-+
-This also means this extension cannot be used at the same time as extensions that rely on JDBC,
-such as the Flyway extension.
-See https://github.com/quarkusio/quarkus/issues/10716.
 * Integration with the Envers extension is not supported.
 * Transaction demarcation cannot be done using `jakarta.transaction.Transactional` or `QuarkusTransaction`;
 if you use xref:hibernate-reactive-panache.adoc[Hibernate Reactive with Panache],
diff --git a/integration-tests/hibernate-orm-compatibility-5.6/postgresql/pom.xml b/integration-tests/hibernate-orm-compatibility-5.6/postgresql/pom.xml
index 05c6745218e5b..6f2fc5189545b 100644
--- a/integration-tests/hibernate-orm-compatibility-5.6/postgresql/pom.xml
+++ b/integration-tests/hibernate-orm-compatibility-5.6/postgresql/pom.xml
@@ -31,10 +31,6 @@
             <groupId>io.quarkus</groupId>
             <artifactId>quarkus-flyway</artifactId>
         </dependency>
-        <dependency>
-            <groupId>org.flywaydb</groupId>
-            <artifactId>flyway-mysql</artifactId>
-        </dependency>
         <dependency>
             <groupId>io.quarkus</groupId>
             <artifactId>quarkus-resteasy-reactive</artifactId>
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/pom.xml b/integration-tests/hibernate-reactive-mysql-agroal-flyway/pom.xml
similarity index 93%
rename from integration-tests/hibernate-reactive-mysql-agroal/pom.xml
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/pom.xml
index ff5e0c37a30b1..3824b2242a8f0 100644
--- a/integration-tests/hibernate-reactive-mysql-agroal/pom.xml
+++ b/integration-tests/hibernate-reactive-mysql-agroal-flyway/pom.xml
@@ -9,9 +9,9 @@
     </parent>
     <modelVersion>4.0.0</modelVersion>
 
-    <artifactId>quarkus-integration-test-hibernate-reactive-mysql-agroal</artifactId>
-    <name>Quarkus - Integration Tests - Hibernate Reactive - MySQL</name>
-    <description>Hibernate Reactive related tests running with the MySQL database</description>
+    <artifactId>quarkus-integration-test-hibernate-reactive-mysql-agroal-flyway</artifactId>
+    <name>Quarkus - Integration Tests - Hibernate Reactive - MySQL - With Agroal and Flyway</name>
+    <description>Hibernate Reactive related tests running with the MySQL database and also using Agroal and Flyway</description>
 
     <properties>
         <reactive-mysql.url>vertx-reactive:mysql://localhost:3306/hibernate_orm_test</reactive-mysql.url>
@@ -39,6 +39,14 @@
             <groupId>io.quarkus</groupId>
             <artifactId>quarkus-resteasy-reactive-jsonb</artifactId>
         </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-flyway</artifactId>
+        </dependency>
+        <dependency>
+            <groupId>org.flywaydb</groupId>
+            <artifactId>flyway-mysql</artifactId>
+        </dependency>
 
         <!-- test dependencies -->
         <dependency>
@@ -118,6 +126,19 @@
                 </exclusion>
             </exclusions>
         </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-flyway-deployment</artifactId>
+            <version>${project.version}</version>
+            <type>pom</type>
+            <scope>test</scope>
+            <exclusions>
+                <exclusion>
+                    <groupId>*</groupId>
+                    <artifactId>*</artifactId>
+                </exclusion>
+            </exclusions>
+        </dependency>
     </dependencies>
 
     <build>
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/src/main/java/io/quarkus/it/hibernate/reactive/mysql/GuineaPig.java b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/java/io/quarkus/it/hibernate/reactive/mysql/GuineaPig.java
similarity index 100%
rename from integration-tests/hibernate-reactive-mysql-agroal/src/main/java/io/quarkus/it/hibernate/reactive/mysql/GuineaPig.java
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/java/io/quarkus/it/hibernate/reactive/mysql/GuineaPig.java
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/src/main/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTestEndpoint.java b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTestEndpoint.java
similarity index 100%
rename from integration-tests/hibernate-reactive-mysql-agroal/src/main/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTestEndpoint.java
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTestEndpoint.java
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/src/main/resources/application.properties b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/application.properties
similarity index 69%
rename from integration-tests/hibernate-reactive-mysql-agroal/src/main/resources/application.properties
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/application.properties
index 97751eb944d68..d48dcb14b0856 100644
--- a/integration-tests/hibernate-reactive-mysql-agroal/src/main/resources/application.properties
+++ b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/application.properties
@@ -1,18 +1,21 @@
+# Reactive datasource config
 quarkus.datasource.db-kind=mysql
 quarkus.datasource.username=hibernate_orm_test
 quarkus.datasource.password=hibernate_orm_test
-
-# Hibernate config
-#quarkus.hibernate-orm.log.sql=true
-quarkus.hibernate-orm.database.generation=drop-and-create
-
-# Reactive config
-quarkus.datasource.reactive=true
 quarkus.datasource.reactive.url=${reactive-mysql.url}
 
+# Blocking datasource config
 quarkus.datasource.blocking.db-kind=mysql
 quarkus.datasource.blocking.username=hibernate_orm_test
 quarkus.datasource.blocking.password=hibernate_orm_test
 quarkus.datasource.blocking.jdbc.url=${mysql.jdbc.url}
 quarkus.datasource.blocking.jdbc=true
 quarkus.datasource.blocking.jdbc.max-size=1
+
+# Hibernate config
+#quarkus.hibernate-orm.log.sql=true
+# We'll use Flyway
+quarkus.hibernate-orm.database.generation=none
+
+# Check that one can use Flyway alongside Hibernate Reactive
+quarkus.flyway.blocking.migrate-at-start=true
diff --git a/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/db/migration/V1.0.0__init.sql b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/db/migration/V1.0.0__init.sql
new file mode 100644
index 0000000000000..5941a38cfb23f
--- /dev/null
+++ b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/main/resources/db/migration/V1.0.0__init.sql
@@ -0,0 +1,5 @@
+create table Pig (
+    id integer not null,
+    name varchar(255),
+    primary key (id)
+) engine=InnoDB;
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLInGraalIT.java b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLInGraalIT.java
similarity index 100%
rename from integration-tests/hibernate-reactive-mysql-agroal/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLInGraalIT.java
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLInGraalIT.java
diff --git a/integration-tests/hibernate-reactive-mysql-agroal/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTest.java b/integration-tests/hibernate-reactive-mysql-agroal-flyway/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTest.java
similarity index 100%
rename from integration-tests/hibernate-reactive-mysql-agroal/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTest.java
rename to integration-tests/hibernate-reactive-mysql-agroal-flyway/src/test/java/io/quarkus/it/hibernate/reactive/mysql/HibernateReactiveMySQLTest.java
diff --git a/integration-tests/pom.xml b/integration-tests/pom.xml
index 69ed92eff3146..c56f7a0c4c229 100644
--- a/integration-tests/pom.xml
+++ b/integration-tests/pom.xml
@@ -225,7 +225,7 @@
                 <module>hibernate-orm-panache-kotlin</module>
                 <module>hibernate-reactive-db2</module>
                 <module>hibernate-reactive-mysql</module>
-                <module>hibernate-reactive-mysql-agroal</module>
+                <module>hibernate-reactive-mysql-agroal-flyway</module>
                 <module>hibernate-reactive-postgresql</module>
                 <module>hibernate-reactive-panache</module>
                 <module>hibernate-reactive-panache-kotlin</module>