diff --git a/conda/environments/all_cuda-118_arch-x86_64.yaml b/conda/environments/all_cuda-118_arch-x86_64.yaml
index 31963d7547..c31b7d44f3 100644
--- a/conda/environments/all_cuda-118_arch-x86_64.yaml
+++ b/conda/environments/all_cuda-118_arch-x86_64.yaml
@@ -32,7 +32,7 @@ dependencies:
 - pytest
 - pytest-cov
 - python>=3.9,<3.11
-- scikit-build>=0.13.1
+- scikit-build-core>=0.7.0
 - sphinx
 - sphinx-click
 - sphinx_rtd_theme
diff --git a/conda/environments/all_cuda-120_arch-x86_64.yaml b/conda/environments/all_cuda-120_arch-x86_64.yaml
index 7446352b54..e0cfd064b4 100644
--- a/conda/environments/all_cuda-120_arch-x86_64.yaml
+++ b/conda/environments/all_cuda-120_arch-x86_64.yaml
@@ -31,7 +31,7 @@ dependencies:
 - pytest
 - pytest-cov
 - python>=3.9,<3.11
-- scikit-build>=0.13.1
+- scikit-build-core>=0.7.0
 - sphinx
 - sphinx-click
 - sphinx_rtd_theme
diff --git a/dependencies.yaml b/dependencies.yaml
index d3e5da5eb1..e6aacf304c 100644
--- a/dependencies.yaml
+++ b/dependencies.yaml
@@ -7,6 +7,7 @@ files:
       arch: [x86_64]
     includes:
       - build
+      - build_legate_wheel
       - checks
       - cudatoolkit
       - docs
@@ -65,6 +66,7 @@ files:
       table: build-system
     includes:
       - build
+      - build_legate_wheel
   legate_py_run:
     output: pyproject
     pyproject_dir: legate
@@ -94,15 +96,14 @@ dependencies:
           - cmake>=3.26.4
           - cython>=3.0.0
           - ninja
-          - scikit-build>=0.13.1
       - output_types: conda
         packages:
           - c-compiler
           - cxx-compiler
+          - scikit-build-core>=0.7.0
       - output_types: [requirements, pyproject]
         packages:
-          - setuptools
-          - wheel
+          - scikit-build-core[pyproject]>=0.7.0
     specific:
       - output_types: conda
         matrices:
@@ -133,6 +134,12 @@ dependencies:
             packages:
               - cuda-version=12.0
               - cuda-nvcc
+  build_legate_wheel:
+    common:
+      - output_types: [requirements, pyproject]
+        packages:
+          - setuptools
+          - wheel
   checks:
     common:
       - output_types: [conda, requirements]
diff --git a/legate/pyproject.toml b/legate/pyproject.toml
index 1e831dec3b..b1c30b53ab 100644
--- a/legate/pyproject.toml
+++ b/legate/pyproject.toml
@@ -7,7 +7,7 @@ requires = [
     "cmake>=3.26.4",
     "cython>=3.0.0",
     "ninja",
-    "scikit-build>=0.13.1",
+    "scikit-build-core[pyproject]>=0.7.0",
     "setuptools",
     "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../dependencies.yaml and run `rapids-dependency-file-generator`.
diff --git a/python/CMakeLists.txt b/python/CMakeLists.txt
index 9e6bfb3c64..28da000ef0 100644
--- a/python/CMakeLists.txt
+++ b/python/CMakeLists.txt
@@ -16,6 +16,9 @@ cmake_minimum_required(VERSION 3.26.4 FATAL_ERROR)
 
 set(kvikio_version 24.02.00)
 
+set(rapids-cmake-repo "vyasr/rapids-cmake")
+set(rapids-cmake-branch "feat/scikit-build-core")
+
 include(../cpp/cmake/fetch_rapids.cmake)
 include(rapids-cpm)
 rapids_cpm_init()
@@ -25,11 +28,7 @@ rapids_cuda_init_architectures(kvikio-python)
 project(
   kvikio-python
   VERSION ${kvikio_version}
-  LANGUAGES # TODO: Building Python extension modules via the python_extension_module requires the C
-            # language to be enabled here. The test project that is built in scikit-build to verify
-            # various linking options for the python library is hardcoded to build with C, so until
-            # that is fixed we need to keep C.
-            C CXX CUDA
+  LANGUAGES CXX CUDA
 )
 
 option(FIND_KVIKIO_CPP
@@ -53,7 +52,7 @@ if(NOT KvikIO_FOUND)
   install(TARGETS kvikio DESTINATION ${cython_lib_dir})
 endif()
 
-include(rapids-cython)
+include(rapids-cython-core)
 rapids_cython_init()
 
 add_subdirectory(cmake)
diff --git a/python/README.md b/python/README.md
new file mode 120000
index 0000000000..32d46ee883
--- /dev/null
+++ b/python/README.md
@@ -0,0 +1 @@
+../README.md
\ No newline at end of file
diff --git a/python/pyproject.toml b/python/pyproject.toml
index dcb79c6f76..e76b567650 100644
--- a/python/pyproject.toml
+++ b/python/pyproject.toml
@@ -2,14 +2,12 @@
 # See file LICENSE for terms.
 
 [build-system]
-build-backend = "setuptools.build_meta"
+build-backend = "scikit_build_core.build"
 requires = [
     "cmake>=3.26.4",
     "cython>=3.0.0",
     "ninja",
-    "scikit-build>=0.13.1",
-    "setuptools",
-    "wheel",
+    "scikit-build-core[pyproject]>=0.7.0",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../dependencies.yaml and run `rapids-dependency-file-generator`.
 
 [project]
@@ -109,3 +107,11 @@ ignore_missing_imports = true
 
 [project.entry-points."numcodecs.codecs"]
 nvcomp_batch = "kvikio.nvcomp_codec:NvCompBatchCodec"
+
+[tool.scikit-build]
+cmake.minimum-version = "3.26.4"
+ninja.make-fallback = true
+cmake.build-type = "Release"
+sdist.reproducible = true
+wheel.packages = ["kvikio"]
+build-dir = "build/{wheel_tag}"
diff --git a/python/setup.py b/python/setup.py
deleted file mode 100644
index 226eb148b9..0000000000
--- a/python/setup.py
+++ /dev/null
@@ -1,17 +0,0 @@
-# Copyright (c) 2021-2023, NVIDIA CORPORATION. All rights reserved.
-# See file LICENSE for terms.
-
-from setuptools import find_packages
-from skbuild import setup
-
-setup(
-    packages=find_packages(exclude=["tests*"]),
-    package_data={
-        # Note: A dict comprehension with an explicit copy is necessary (rather
-        # than something simpler like a dict.fromkeys) because otherwise every
-        # package will refer to the same list and skbuild modifies it in place.
-        key: ["*.pyi", "*.pxd"]
-        for key in find_packages(include=["kvikio._lib"])
-    },
-    zip_safe=False,
-)