diff --git a/.changeset/many-shrimps-rush.md b/.changeset/many-shrimps-rush.md
new file mode 100644
index 000000000000..e203e162d66d
--- /dev/null
+++ b/.changeset/many-shrimps-rush.md
@@ -0,0 +1,5 @@
+---
+'@sveltejs/adapter-vercel': patch
+---
+
+fix: throw error if `isr` is combined with `runtime: 'edge'`
diff --git a/packages/adapter-vercel/index.js b/packages/adapter-vercel/index.js
index 0f02652f8e3d..1685513284c3 100644
--- a/packages/adapter-vercel/index.js
+++ b/packages/adapter-vercel/index.js
@@ -171,8 +171,18 @@ const plugin = function (defaults = {}) {
 				const config = { runtime, ...defaults, ...route.config };
 
 				if (config.isr) {
+					const directory = path.relative('.', builder.config.kit.files.routes + route.id);
+
+					if (runtime !== 'nodejs16.x' && runtime !== 'nodejs18.x') {
+						throw new Error(
+							`${directory}: Routes using \`isr\` must use either \`runtime: 'nodejs16.x'\` or \`runtime: 'nodejs18.x'\``
+						);
+					}
+
 					if (config.isr.allowQuery?.includes('__pathname')) {
-						throw new Error('__pathname is a reserved query parameter for isr.allowQuery');
+						throw new Error(
+							`${directory}: \`__pathname\` is a reserved query parameter for \`isr.allowQuery\``
+						);
 					}
 
 					isr_config.set(route, {