diff --git a/temporalio/worker/_workflow_instance.py b/temporalio/worker/_workflow_instance.py
index 3767f451..2e185636 100644
--- a/temporalio/worker/_workflow_instance.py
+++ b/temporalio/worker/_workflow_instance.py
@@ -242,6 +242,16 @@ def __init__(self, det: WorkflowInstanceDetails) -> None:
         # Set ourselves on our own loop
         temporalio.workflow._Runtime.set_on_loop(self, self)
 
+        # After GC, Python raises GeneratorExit calls from all awaiting tasks.
+        # Then in a finally of such an await, another exception can swallow
+        # these causing even more issues. We will set ourselves as deleted so we
+        # can check in some places to swallow these errors on tear down.
+        self._deleting = False
+
+    def __del__(self) -> None:
+        # We have confirmed there are no super() versions of __del__
+        self._deleting = True
+
     #### Activation functions ####
     # These are in alphabetical order and besides "activate", all other calls
     # are "_apply_" + the job field name.
@@ -629,14 +639,26 @@ def _apply_start_workflow(
         # Async call to run on the scheduler thread. This will be wrapped in
         # another function which applies exception handling.
         async def run_workflow(input: ExecuteWorkflowInput) -> None:
-            result = await self._inbound.execute_workflow(input)
-            result_payloads = self._payload_converter.to_payloads([result])
-            if len(result_payloads) != 1:
-                raise ValueError(
-                    f"Expected 1 result payload, got {len(result_payloads)}"
-                )
-            command = self._add_command()
-            command.complete_workflow_execution.result.CopyFrom(result_payloads[0])
+            try:
+                result = await self._inbound.execute_workflow(input)
+                result_payloads = self._payload_converter.to_payloads([result])
+                if len(result_payloads) != 1:
+                    raise ValueError(
+                        f"Expected 1 result payload, got {len(result_payloads)}"
+                    )
+                command = self._add_command()
+                command.complete_workflow_execution.result.CopyFrom(result_payloads[0])
+            except BaseException as err:
+                # During tear down, generator exit and event loop exceptions can occur
+                if not self._deleting:
+                    raise
+                if not isinstance(
+                    err,
+                    (GeneratorExit, temporalio.workflow._NotInWorkflowEventLoopError),
+                ):
+                    logger.debug(
+                        "Ignoring exception while deleting workflow", exc_info=True
+                    )
 
         # Schedule it
         input = ExecuteWorkflowInput(
@@ -1260,6 +1282,16 @@ async def _run_top_level_workflow_function(self, coro: Awaitable[None]) -> None:
             else:
                 # All other exceptions fail the task
                 self._current_activation_error = err
+        except BaseException as err:
+            # During tear down, generator exit and no-runtime exceptions can appear
+            if not self._deleting:
+                raise
+            if not isinstance(
+                err, (GeneratorExit, temporalio.workflow._NotInWorkflowEventLoopError)
+            ):
+                logger.debug(
+                    "Ignoring exception while deleting workflow", exc_info=True
+                )
 
     def _set_workflow_failure(self, err: temporalio.exceptions.FailureError) -> None:
         # All other failure errors fail the workflow
diff --git a/temporalio/workflow.py b/temporalio/workflow.py
index 4c735e53..67720f5a 100644
--- a/temporalio/workflow.py
+++ b/temporalio/workflow.py
@@ -340,7 +340,7 @@ class _Runtime(ABC):
     def current() -> _Runtime:
         loop = _Runtime.maybe_current()
         if not loop:
-            raise RuntimeError("Not in workflow event loop")
+            raise _NotInWorkflowEventLoopError("Not in workflow event loop")
         return loop
 
     @staticmethod
@@ -3843,6 +3843,12 @@ def __init__(self, message: str) -> None:
         self.message = message
 
 
+class _NotInWorkflowEventLoopError(temporalio.exceptions.TemporalError):
+    def __init__(self, *args: object) -> None:
+        super().__init__("Not in workflow event loop")
+        self.message = "Not in workflow event loop"
+
+
 class VersioningIntent(Enum):
     """Indicates whether the user intends certain commands to be run on a compatible worker Build
     Id version or not.
diff --git a/tests/worker/test_workflow.py b/tests/worker/test_workflow.py
index 6bec62f9..d84ed646 100644
--- a/tests/worker/test_workflow.py
+++ b/tests/worker/test_workflow.py
@@ -5,6 +5,7 @@
 import logging.handlers
 import pickle
 import queue
+import sys
 import threading
 import uuid
 from abc import ABC, abstractmethod
@@ -2843,3 +2844,71 @@ async def test_manual_result_type(client: Client):
         assert res3 == {"some_string": "from-query"}
         res4 = await handle.query("some_query", result_type=ManualResultType)
         assert res4 == ManualResultType(some_string="from-query")
+
+
+@workflow.defn
+class SwallowGeneratorExitWorkflow:
+    def __init__(self) -> None:
+        self._signal_count = 0
+
+    @workflow.run
+    async def run(self) -> None:
+        try:
+            # Wait for signal count to reach 2
+            await workflow.wait_condition(lambda: self._signal_count > 1)
+        finally:
+            # This finally, on eviction, is actually called because the above
+            # await raises GeneratorExit. Then this will raise a
+            # _NotInWorkflowEventLoopError swallowing that.
+            await workflow.wait_condition(lambda: self._signal_count > 2)
+
+    @workflow.signal
+    async def signal(self) -> None:
+        self._signal_count += 1
+
+    @workflow.query
+    async def signal_count(self) -> int:
+        return self._signal_count
+
+
+async def test_swallow_generator_exit(client: Client):
+    if sys.version_info < (3, 8):
+        pytest.skip("sys.unraisablehook not in 3.7")
+    # This test simulates GeneratorExit and GC issues by forcing eviction on
+    # each step
+    async with new_worker(
+        client, SwallowGeneratorExitWorkflow, max_cached_workflows=0
+    ) as worker:
+        # Put a hook to catch unraisable exceptions
+        old_hook = sys.unraisablehook
+        hook_calls: List[Any] = []
+        sys.unraisablehook = hook_calls.append
+        try:
+            handle = await client.start_workflow(
+                SwallowGeneratorExitWorkflow.run,
+                id=f"wf-{uuid.uuid4()}",
+                task_queue=worker.task_queue,
+            )
+
+            async def signal_count() -> int:
+                return await handle.query(SwallowGeneratorExitWorkflow.signal_count)
+
+            # Confirm signal count as 0
+            await assert_eq_eventually(0, signal_count)
+
+            # Send signal and confirm it's at 1
+            await handle.signal(SwallowGeneratorExitWorkflow.signal)
+            await assert_eq_eventually(1, signal_count)
+
+            await handle.signal(SwallowGeneratorExitWorkflow.signal)
+            await assert_eq_eventually(2, signal_count)
+
+            await handle.signal(SwallowGeneratorExitWorkflow.signal)
+            await assert_eq_eventually(3, signal_count)
+
+            await handle.result()
+        finally:
+            sys.unraisablehook = old_hook
+
+        # Confirm no unraisable exceptions
+        assert not hook_calls