diff --git a/vaadin-button-flow-parent/vaadin-button-flow/src/main/java/com/vaadin/flow/component/button/Button.java b/vaadin-button-flow-parent/vaadin-button-flow/src/main/java/com/vaadin/flow/component/button/Button.java
index 426173051bb..6d37053ba03 100644
--- a/vaadin-button-flow-parent/vaadin-button-flow/src/main/java/com/vaadin/flow/component/button/Button.java
+++ b/vaadin-button-flow-parent/vaadin-button-flow/src/main/java/com/vaadin/flow/component/button/Button.java
@@ -20,6 +20,8 @@
 import java.util.stream.Collectors;
 import java.util.stream.Stream;
 
+import com.vaadin.experimental.Feature;
+import com.vaadin.experimental.FeatureFlags;
 import com.vaadin.flow.component.ClickEvent;
 import com.vaadin.flow.component.ClickNotifier;
 import com.vaadin.flow.component.Component;
@@ -30,7 +32,11 @@
 import com.vaadin.flow.component.HasSize;
 import com.vaadin.flow.component.HasStyle;
 import com.vaadin.flow.component.HasText;
+import com.vaadin.flow.component.Key;
+import com.vaadin.flow.component.KeyModifier;
+import com.vaadin.flow.component.ShortcutRegistration;
 import com.vaadin.flow.component.Tag;
+import com.vaadin.flow.component.UI;
 import com.vaadin.flow.component.dependency.JsModule;
 import com.vaadin.flow.component.dependency.NpmPackage;
 import com.vaadin.flow.component.html.Image;
@@ -39,7 +45,9 @@
 import com.vaadin.flow.component.shared.HasThemeVariant;
 import com.vaadin.flow.component.shared.HasTooltip;
 import com.vaadin.flow.component.shared.internal.DisableOnClickController;
+import com.vaadin.flow.dom.DisabledUpdateMode;
 import com.vaadin.flow.dom.Element;
+import com.vaadin.flow.shared.Registration;
 
 /**
  * The Button component allows users to perform actions. It comes in several
@@ -341,12 +349,111 @@ public boolean isDisableOnClick() {
         return disableOnClickController.isDisableOnClick();
     }
 
+    /**
+     * Sets the button explicitly disabled or enabled. When disabled, the button
+     * is rendered as "dimmed" and prevents all user interactions (mouse and
+     * keyboard).
+     * <p>
+     * Since disabled buttons are not focusable and cannot react to hover events
+     * by default, it can cause accessibility issues by making them entirely
+     * invisible to assistive technologies, and prevents the use of Tooltips to
+     * explain why the action is not available. This can be addressed with the
+     * feature flag {@code accessibleDisabledButtons}, which makes disabled
+     * buttons focusable and hoverable, while preventing them from being
+     * triggered. To enable this feature flag, add the following line to
+     * {@code src/main/resources/vaadin-featureflags.properties}:
+     *
+     * <pre>
+     * com.vaadin.experimental.accessibleDisabledButtons = true
+     * </pre>
+     *
+     * This feature flag will also enable focus events and focus shortcuts for
+     * disabled buttons.
+     */
     @Override
     public void setEnabled(boolean enabled) {
         Focusable.super.setEnabled(enabled);
         disableOnClickController.onSetEnabled(enabled);
     }
 
+    /**
+     * {@inheritDoc}
+     * <p>
+     * By default, focus shortcuts are only active when the button is enabled.
+     * To make disabled buttons also focusable, enable the following feature
+     * flag in {@code src/main/resources/vaadin-featureflags.properties}:
+     *
+     * <pre>
+     * com.vaadin.experimental.accessibleDisabledButtons = true
+     * </pre>
+     *
+     * This feature flag will enable focus events and focus shortcuts for
+     * disabled buttons.
+     */
+    @Override
+    public ShortcutRegistration addFocusShortcut(Key key,
+            KeyModifier... keyModifiers) {
+        ShortcutRegistration registration = Focusable.super.addFocusShortcut(
+                key, keyModifiers);
+        if (isFeatureFlagEnabled(FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS)) {
+            registration.setDisabledUpdateMode(DisabledUpdateMode.ALWAYS);
+        }
+        return registration;
+    }
+
+    /**
+     * {@inheritDoc}
+     * <p>
+     * By default, buttons are only focusable in the enabled state. To make
+     * disabled buttons also focusable, enable the following feature flag in
+     * {@code src/main/resources/vaadin-featureflags.properties}:
+     *
+     * <pre>
+     * com.vaadin.experimental.accessibleDisabledButtons = true
+     * </pre>
+     *
+     * This feature flag will enable focus events and focus shortcuts for
+     * disabled buttons.
+     */
+    @SuppressWarnings({ "unchecked", "rawtypes" })
+    @Override
+    public Registration addFocusListener(
+            ComponentEventListener<FocusEvent<Button>> listener) {
+        return getEventBus().addListener(FocusEvent.class,
+                (ComponentEventListener) listener, registration -> {
+                    if (isFeatureFlagEnabled(
+                            FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS)) {
+                        registration.setDisabledUpdateMode(
+                                DisabledUpdateMode.ALWAYS);
+                    }
+                });
+    }
+
+    /**
+     * {@inheritDoc}
+     * <p>
+     * By default, buttons are only focusable in the enabled state. To make
+     * disabled buttons also focusable, enable the following feature flag in
+     * {@code src/main/resources/vaadin-featureflags.properties}:
+     *
+     * <pre>
+     * com.vaadin.experimental.accessibleDisabledButtons = true
+     * </pre>
+     */
+    @SuppressWarnings({ "unchecked", "rawtypes" })
+    @Override
+    public Registration addBlurListener(
+            ComponentEventListener<BlurEvent<Button>> listener) {
+        return getEventBus().addListener(BlurEvent.class,
+                (ComponentEventListener) listener, registration -> {
+                    if (isFeatureFlagEnabled(
+                            FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS)) {
+                        registration.setDisabledUpdateMode(
+                                DisabledUpdateMode.ALWAYS);
+                    }
+                });
+    }
+
     private void updateIconSlot() {
         iconComponent.getElement().setAttribute("slot",
                 iconAfterText ? "suffix" : "prefix");
@@ -410,4 +517,22 @@ private void updateThemeAttribute() {
             getThemeNames().remove("icon");
         }
     }
+
+    /**
+     * Checks whether the given feature flag is active.
+     *
+     * @param feature
+     *            the feature flag to check
+     * @return {@code true} if the feature flag is active, {@code false}
+     *         otherwise
+     */
+    private boolean isFeatureFlagEnabled(Feature feature) {
+        UI ui = UI.getCurrent();
+        if (ui == null) {
+            return false;
+        }
+
+        return FeatureFlags.get(ui.getSession().getService().getContext())
+                .isEnabled(feature);
+    }
 }
diff --git a/vaadin-button-flow-parent/vaadin-button-flow/src/test/java/com/vaadin/flow/component/button/tests/AccessibleDisabledButtonTest.java b/vaadin-button-flow-parent/vaadin-button-flow/src/test/java/com/vaadin/flow/component/button/tests/AccessibleDisabledButtonTest.java
new file mode 100644
index 00000000000..f638c6d0f7e
--- /dev/null
+++ b/vaadin-button-flow-parent/vaadin-button-flow/src/test/java/com/vaadin/flow/component/button/tests/AccessibleDisabledButtonTest.java
@@ -0,0 +1,178 @@
+/*
+ * Copyright 2000-2025 Vaadin Ltd.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License"); you may not
+ * use this file except in compliance with the License. You may obtain a copy of
+ * the License at
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS, WITHOUT
+ * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the
+ * License for the specific language governing permissions and limitations under
+ * the License.
+ */
+package com.vaadin.flow.component.button.tests;
+
+import org.junit.After;
+import org.junit.Before;
+import org.junit.Test;
+import org.mockito.MockedStatic;
+import org.mockito.Mockito;
+
+import com.vaadin.experimental.FeatureFlags;
+import com.vaadin.flow.component.Component;
+import com.vaadin.flow.component.ComponentEventListener;
+import com.vaadin.flow.component.ComponentUtil;
+import com.vaadin.flow.component.Key;
+import com.vaadin.flow.component.KeyDownEvent;
+import com.vaadin.flow.component.UI;
+import com.vaadin.flow.component.button.Button;
+import com.vaadin.flow.dom.DomEvent;
+import com.vaadin.flow.dom.Element;
+import com.vaadin.flow.internal.nodefeature.ElementListenerMap;
+import com.vaadin.flow.server.VaadinContext;
+import com.vaadin.flow.server.VaadinService;
+import com.vaadin.flow.server.VaadinSession;
+
+import elemental.json.Json;
+
+public class AccessibleDisabledButtonTest {
+
+    private MockedStatic<FeatureFlags> mockFeatureFlagsStatic = Mockito
+            .mockStatic(FeatureFlags.class);
+
+    private FeatureFlags mockFeatureFlags = Mockito.mock(FeatureFlags.class);
+
+    private Button button = Mockito.spy(Button.class);
+
+    @SuppressWarnings("rawtypes")
+    private ComponentEventListener mockFocusListener = Mockito
+            .mock(ComponentEventListener.class);
+
+    @SuppressWarnings("rawtypes")
+    private ComponentEventListener mockBlurListener = Mockito
+            .mock(ComponentEventListener.class);
+
+    private UI ui = new UI();
+
+    @Before
+    public void setUp() {
+        VaadinSession mockSession = Mockito.mock(VaadinSession.class);
+        VaadinService mockService = Mockito.mock(VaadinService.class);
+        VaadinContext mockContext = Mockito.mock(VaadinContext.class);
+
+        Mockito.when(mockSession.getService()).thenReturn(mockService);
+        Mockito.when(mockService.getContext()).thenReturn(mockContext);
+        mockFeatureFlagsStatic.when(() -> FeatureFlags.get(mockContext))
+                .thenReturn(mockFeatureFlags);
+
+        ui.getInternals().setSession(mockSession);
+        UI.setCurrent(ui);
+
+        button.setEnabled(false);
+    }
+
+    @After
+    public void tearDown() {
+        mockFeatureFlagsStatic.close();
+        UI.setCurrent(null);
+    }
+
+    @SuppressWarnings("unchecked")
+    @Test
+    public void accessibleButtonsDisabled_focusListenerDisabled() {
+        button.addFocusListener(mockFocusListener);
+
+        fakeClientDomEvent(button, "focus");
+
+        Mockito.verify(mockFocusListener, Mockito.never())
+                .onComponentEvent(Mockito.any());
+    }
+
+    @SuppressWarnings("unchecked")
+    @Test
+    public void accessibleButtonsEnabled_focusListenerEnabled() {
+        Mockito.when(mockFeatureFlags
+                .isEnabled(FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS))
+                .thenReturn(true);
+
+        button.addFocusListener(mockFocusListener);
+
+        fakeClientDomEvent(button, "focus");
+
+        Mockito.verify(mockFocusListener, Mockito.times(1))
+                .onComponentEvent(Mockito.any());
+    }
+
+    @SuppressWarnings("unchecked")
+    @Test
+    public void accessibleButtonsDisabled_blurListenerDisabled() {
+        button.addBlurListener(mockBlurListener);
+
+        fakeClientDomEvent(button, "blur");
+
+        Mockito.verify(mockBlurListener, Mockito.never())
+                .onComponentEvent(Mockito.any());
+    }
+
+    @SuppressWarnings("unchecked")
+    @Test
+    public void accessibleButtonsEnabled_blurListenerEnabled() {
+        Mockito.when(mockFeatureFlags
+                .isEnabled(FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS))
+                .thenReturn(true);
+
+        button.addBlurListener(mockBlurListener);
+
+        fakeClientDomEvent(button, "blur");
+
+        Mockito.verify(mockBlurListener, Mockito.times(1))
+                .onComponentEvent(Mockito.any());
+    }
+
+    @Test
+    public void accessibleButtonsDisabled_focusShortcutDisabled() {
+        button.addFocusShortcut(Key.KEY_A);
+        ui.add(button);
+        ui.getInternals().getStateTree().runExecutionsBeforeClientResponse();
+
+        var keydownEvent = new KeyDownEvent(button, "A"); // actual key of the
+                                                          // event doesn't
+                                                          // matter with this
+                                                          // test setup, as the
+                                                          // filtering happens
+                                                          // on the client side
+        ComponentUtil.fireEvent(ui, keydownEvent);
+
+        Mockito.verify(button, Mockito.never()).focus();
+    }
+
+    @Test
+    public void accessibleButtonsEnabled_focusShortcutEnabled() {
+        Mockito.when(mockFeatureFlags
+                .isEnabled(FeatureFlags.ACCESSIBLE_DISABLED_BUTTONS))
+                .thenReturn(true);
+
+        button.addFocusShortcut(Key.KEY_A);
+        ui.add(button);
+        ui.getInternals().getStateTree().runExecutionsBeforeClientResponse();
+
+        var keydownEvent = new KeyDownEvent(button, "A"); // actual key of the
+                                                          // event doesn't
+                                                          // matter with this
+                                                          // test setup, as the
+                                                          // filtering happens
+                                                          // on the client side
+        ComponentUtil.fireEvent(ui, keydownEvent);
+
+        Mockito.verify(button, Mockito.times(1)).focus();
+    }
+
+    private void fakeClientDomEvent(Component component, String eventName) {
+        Element element = component.getElement();
+        DomEvent event = new DomEvent(element, eventName, Json.createObject());
+        element.getNode().getFeature(ElementListenerMap.class).fireEvent(event);
+    }
+}
diff --git a/vaadin-menu-bar-flow-parent/vaadin-menu-bar-flow/src/main/java/com/vaadin/flow/component/menubar/MenuBarItem.java b/vaadin-menu-bar-flow-parent/vaadin-menu-bar-flow/src/main/java/com/vaadin/flow/component/menubar/MenuBarItem.java
index 04cae855cc0..1d115622139 100644
--- a/vaadin-menu-bar-flow-parent/vaadin-menu-bar-flow/src/main/java/com/vaadin/flow/component/menubar/MenuBarItem.java
+++ b/vaadin-menu-bar-flow-parent/vaadin-menu-bar-flow/src/main/java/com/vaadin/flow/component/menubar/MenuBarItem.java
@@ -36,6 +36,29 @@ protected MenuBarSubMenu createSubMenu() {
         return new MenuBarSubMenu(this, contentReset);
     }
 
+    /**
+     * Sets the menu item explicitly disabled or enabled. When disabled, the
+     * menu item is rendered as "dimmed" and prevents all user interactions
+     * (mouse and keyboard).
+     * <p>
+     * Since disabled buttons (root-level items) are not focusable and cannot
+     * react to hover events by default, it can cause accessibility issues by
+     * making them entirely invisible to assistive technologies, and prevents
+     * the use of Tooltips to explain why the action is not available. This can
+     * be addressed with the feature flag {@code accessibleDisabledButtons},
+     * which makes disabled buttons focusable and hoverable, while preventing
+     * them from being triggered. To enable this feature flag, add the following
+     * line to {@code src/main/resources/vaadin-featureflags.properties}:
+     *
+     * <pre>
+     * com.vaadin.experimental.accessibleDisabledButtons = true
+     * </pre>
+     */
+    @Override
+    public void setEnabled(boolean enabled) {
+        super.setEnabled(enabled);
+    }
+
     /**
      * @inheritDoc
      */