diff --git a/packages/vite/src/node/plugins/esbuild.ts b/packages/vite/src/node/plugins/esbuild.ts
index bc4a1f780a54d5..6fdf74ee05c4ad 100644
--- a/packages/vite/src/node/plugins/esbuild.ts
+++ b/packages/vite/src/node/plugins/esbuild.ts
@@ -27,9 +27,9 @@ import { searchForWorkspaceRoot } from '..'
 const debug = createDebugger('vite:esbuild')
 
 const INJECT_HELPERS_IIFE_RE =
-  /(.*)(var [^\s]+=function\(.*\){"use strict";)(.*)/
+  /(.*)(var [^\s]+=function\([^)]*?\){"use strict";)(.*)/
 const INJECT_HELPERS_UMD_RE =
-  /(.*)(\(function\(.*\){.+amd.+function\(.*\){"use strict";)(.*)/
+  /(.*)(\(function\([^)]*?\){.+amd.+function\([^)]*?\){"use strict";)(.*)/
 
 let server: ViteDevServer