diff --git a/src/init.cpp b/src/init.cpp
index 19efc69aaa2ba9..5ade692a4ab0f2 100644
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -908,6 +908,23 @@ bool AppInitParameterInteraction(const ArgsManager& args)
         InitWarning(warnings);
     }
 
+    // Check if we are running on exFAT on MacOS
+#ifdef __APPLE__
+    std::vector<fs::path> paths_to_check = {args.GetDataDirNet(), args.GetBlocksDirPath()};
+    for (const auto& path : paths_to_check) {
+        FSType fs_type = GetFilesystemType(path);
+        switch(fs_type) {
+            case FSType::EXFAT:
+                return InitError(strprintf(_("Specified directory \"%s\" is exFAT which is known to cause corruption on MacOS."), fs::PathToString(path)));
+            case FSType::ERROR:
+                LogPrintf("Warning: Failed to detect filesystem at %s\n", fs::PathToString(path));
+                break;
+            default:
+                break;
+        }
+    }
+#endif
+
     if (!fs::is_directory(args.GetBlocksDirPath())) {
         return InitError(strprintf(_("Specified blocks directory \"%s\" does not exist."), args.GetArg("-blocksdir", "")));
     }
diff --git a/src/util/fs_helpers.cpp b/src/util/fs_helpers.cpp
index 4d06afe1442022..243f2dc5f64aba 100644
--- a/src/util/fs_helpers.cpp
+++ b/src/util/fs_helpers.cpp
@@ -41,6 +41,10 @@
 #include <shlobj.h> /* For SHGetSpecialFolderPathW */
 #endif // WIN32
 
+#ifdef __APPLE__
+#include <sys/statfs.h>
+#endif
+
 /** Mutex to protect dir_locks. */
 static GlobalMutex cs_dir_locks;
 /** A map that contains all the currently held directory locks. After
@@ -309,3 +313,17 @@ std::optional<fs::perms> InterpretPermString(const std::string& s)
         return std::nullopt;
     }
 }
+
+#ifdef __APPLE__
+FSType GetFilesystemType(const fs::path& path) {
+    struct statfs fs_info;
+    if (statfs(path.c_str(), &fs_info) != 0) {
+        return FSType::ERROR;
+    }
+
+    if (strcmp(fs_info.f_fstypename, "exfat") == 0) {
+        return FSType::EXFAT;
+    }
+    return FSType::OTHER;
+}
+#endif
diff --git a/src/util/fs_helpers.h b/src/util/fs_helpers.h
index 28dd6d979d5253..7423da82a42ec8 100644
--- a/src/util/fs_helpers.h
+++ b/src/util/fs_helpers.h
@@ -14,6 +14,23 @@
 #include <limits>
 #include <optional>
 
+#ifdef __APPLE__
+enum class FSType {
+    EXFAT,
+    OTHER,
+    ERROR
+};
+
+/**
+ * Detect filesystem type for a given path.
+ * Currently identifies exFAT filesystems which cause issues on MacOS.
+ *
+ * @param[in] path The directory path to check
+ * @return FSType enum indicating the filesystem type
+ */
+FSType GetFilesystemType(const fs::path& path);
+#endif
+
 /**
  * Ensure file contents are fully committed to disk, using a platform-specific
  * feature analogous to fsync().