Implementation of the pyloric pacemaker network of the lobster stomatogastric ganglion system of Prinz, Marder, et al.
See http://www.opensourcebrain.org/projects/pyloricnetwork for more details.
This project contains a neuroConstruct project which generates a version of the pyloric pacemaker model. The channel models have been converted to ChannelML and the network can be exported to:
- NeuroML v1.8.1
- NEURON
- GENESIS
- MOOSE
- NeuroML v2
This is based on work by Aditya Gilra, Boris Marin and Padriag Gleeson. A unified version of the neuroConstruct model is in the top level neuroConstruct folder.
Aditya Gilra's original implementation of the pyloric pacemaker model of the lobster somatogastric ganglion system in the AdityaGilraMOOSEnC folder.
The 3 cell network is for fig 3d from : Similar network activity from disparate circuit parameters Astrid A Prinz, Dirk Bucher & Eve Marder Nature Neuroscience, 2004.
The cell models and channel mechanisms are from: Alternative to Hand-Tuning Conductance-Based Models: Construction and Analysis of Databases of Model Neurons Astrid A. Prinz, Cyrus P. Billimoria, and Eve Marder, J Neurophysiol 90: 3998–4015, 2003.
The same cell is used as the basis for 3 cells AB_PD, LP and PY with different channel densities, connected in the pyloric rhythm generator network specified in Fig 3d of Prinz, Bucher and Marder, 2004 above. Differences from the original model: Synapses are thresholded rather than graded.
A Python file which can be used to load the NeuroML into MOOSE is at pyloric_net_MOOSE.py
Boris Marin's implementation of the pyloric pacemaker model of the lobster somatogastric ganglion system was based on, from
Prinz, A. A., Thirumalai, V., & Marder, E. (2003). The functional consequences of changes in the strength and duration of synaptic inputs to oscillatory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(3), 943–54. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12574423
The code in this repository is provided under the terms of the software license included with it. If you use this model in your research, we respectfully ask you to cite the references outlined in the CITATION file.